bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2021,
Volume and Issue:
unknown
Published: Oct. 15, 2021
ABSTRACT
Memorization
and
generalization
are
complementary
cognitive
processes
that
jointly
promote
adaptive
behavior.
For
example,
animals
should
memorize
a
safe
route
to
water
source
generalize
features
allow
them
find
new
sources,
without
expecting
paths
exactly
resemble
previous
ones.
Memory
aids
by
allowing
the
brain
extract
general
patterns
from
specific
instances
were
spread
across
time,
such
as
when
humans
progressively
build
semantic
knowledge
episodic
memories.
This
process
depends
on
neural
mechanisms
of
systems
consolidation,
whereby
hippocampal-neocortical
interactions
gradually
construct
neocortical
memory
traces
consolidating
hippocampal
precursors.
However,
recent
data
suggest
consolidation
only
applies
subset
memories;
why
certain
memories
consolidate
more
than
others
remains
unclear.
Here
we
introduce
novel
network
formalization
highlights
an
overlooked
tension
between
transfer
generalization,
resolve
this
postulating
it
generalization.
We
specifically
show
unregulated
can
be
detrimental
in
unpredictable
environments,
whereas
optimizing
for
generates
high-fidelity,
dual-system
supporting
both
theory
generalization-optimized
produces
transfers
some
components
neocortex
leaves
dependent
hippocampus.
It
thus
provides
normative
principle
reconceptualizing
numerous
puzzling
observations
field
insight
into
how
behavior
benefits
learning
specialized
memorization
Oxford University Press eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 7, 2024
Abstract
The
Neuropsychology
of
Anxiety
first
appeared
in
1982
as
the
volume
Oxford
Psychology
Series,
and
it
quickly
established
itself
classic
work
on
subject.
It
second
edition
(appearing
2000)
have
been
cited
at
a
steadily
increasing
rate
passing
500/year
2017.
field
has
continued
to
expand
last
quarter
century
necessitating
this
third
edition.
This
completely
updated
revised
(with
many
figures
converted
colour)
retains
original
core
concepts
while
expanding
often
simplifying
details.
includes
new
chapter
prefrontal
cortex,
which
integrates
frontal
hippocampal
views
anxiety
an
extensively
modified
personality
providing
basis
for
further
developments
Reinforcement
Sensitivity
Theory.
book
is
essential
postgraduate
students
researchers
experimental
psychology
neuroscience,
well
all
clinical
psychologists
psychiatrists.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(8), P. 3207 - 3219
Published: June 27, 2023
Tremendous
strides
have
been
made
in
our
understanding
of
the
neurobiological
substrates
memory
-
so-called
"engram".
Here,
we
integrate
recent
progress
engram
field
to
illustrate
how
neurons
transform
across
"lifespan"
a
from
initial
encoding,
consolidation
and
retrieval,
ultimately
forgetting.
To
do
so,
first
describe
cell-intrinsic
properties
shape
emergence
at
encoding.
Second,
highlight
these
encoding
preferentially
participate
synaptic-
systems-level
memory.
Third,
changes
during
guide
neural
reactivation
facilitate
recall.
Fourth,
mechanisms
forgetting,
can
counteract
established
consolidation,
retrieval.
Motivated
by
experimental
results
four
sections,
conclude
proposing
some
conceptual
extensions
traditional
view
engram,
including
broadening
cell-type
participation
within
engrams
stages.
In
collection,
review
synthesizes
general
principles
stages,
describes
future
avenues
further
understand
dynamic
engram.
Nature Neuroscience,
Journal Year:
2023,
Volume and Issue:
26(8), P. 1438 - 1448
Published: July 20, 2023
Abstract
Memorization
and
generalization
are
complementary
cognitive
processes
that
jointly
promote
adaptive
behavior.
For
example,
animals
should
memorize
safe
routes
to
specific
water
sources
generalize
from
these
memories
discover
environmental
features
predict
new
ones.
These
functions
depend
on
systems
consolidation
mechanisms
construct
neocortical
memory
traces
hippocampal
precursors,
but
why
only
applies
a
subset
of
is
unclear.
Here
we
introduce
neural
network
formalization
reveals
an
overlooked
tension—unregulated
transfer
can
cause
overfitting
harm
in
unpredictable
world.
We
resolve
this
tension
by
postulating
consolidate
when
it
aids
generalization.
This
framework
accounts
for
partial
hippocampal–cortical
provides
normative
principle
reconceptualizing
numerous
observations
the
field.
Generalization-optimized
thus
insight
into
how
behavior
benefits
learning
specialized
memorization
Trends in Cognitive Sciences,
Journal Year:
2024,
Volume and Issue:
28(4), P. 339 - 351
Published: March 4, 2024
How
do
passing
moments
turn
into
lasting
memories?
Sheltered
from
external
tasks
and
distractions,
sleep
constitutes
an
optimal
state
for
the
brain
to
reprocess
consolidate
previous
experiences.
Recent
work
suggests
that
consolidation
is
governed
by
intricate
interaction
of
slow
oscillations
(SOs),
spindles,
ripples
–
electrophysiological
rhythms
orchestrate
neuronal
processing
communication
within
across
memory
circuits.
This
review
describes
how
sequential
SO–spindle–ripple
coupling
provides
a
temporally
spatially
fine-tuned
mechanism
selectively
strengthen
target
memories
hippocampal
cortical
networks.
Coupled
might
be
harnessed
not
only
enhance
overnight
retention,
but
also
combat
decline
associated
with
healthy
ageing
neurodegenerative
diseases.
We
review
the
literature
on
systems
consolidation
by
providing
a
brief
history
of
field
to
place
current
research
in
proper
perspective.
cover
both
humans
and
non-humans,
which
are
highly
related
despite
differences
techniques
tasks
that
used.
argue
understanding
interactions
between
hippocampus
neocortex
(and
other
structures)
underlie
consolidation,
depend
appreciating
close
correspondence
psychological
neural
representations
memory,
as
postulated
Multiple
Trace
Theory
Transformation
Theory.
end
evaluating
different
theories
light
evidence
we
reviewed
suggest
concept
with
its
central
concern
time-limited
role
plays
may
have
outlived
usefulness.
replacing
it
program
processes
mechanisms
changes
memory
across
lifetime
–
natural
change.
