Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus DOI Creative Commons
James C. Dooley, Greta Sokoloff, Mark S. Blumberg

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(24), P. 5501 - 5511.e5

Published: Nov. 1, 2021

With our eyes closed, we can track a limb's moment-to-moment location in space. If this capacity relied solely on sensory feedback from the limb, would always be step behind because takes time: for execution of rapid and precise movements, such lags are not tolerable. Nervous systems solve problem by computing representations—or internal models—that mimic movements as they happening, with associated neural activity occurring after motor command but before feedback. Research adults indicates that cerebellum is necessary to compute models. What known, however, when—and under what conditions—this computational develops. Here, taking advantage unique kinematic features discrete, spontaneous limb twitches characterize active sleep, captured developmental emergence cerebellar-dependent model. Using rats at postnatal days (P) 12, P16, P20, compared ventral posterior (VP) lateral (VL) thalamic nuclei, both which receive somatosensory input only latter receives cerebellar input. At all ages, twitch-related VP lagged movement, consistent processing; similar was observed VL through P16. no longer movement instead precisely mimicked itself; depended In addition demonstrating models these findings implicate their development calibration through, least, preweanling period.

Language: Английский

Direct neural perturbations reveal a dynamical mechanism for robust computation DOI Creative Commons
Daniel J. O’Shea, Lea Duncker,

Werapong Goo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Dec. 16, 2022

Abstract The rich repertoire of skilled mammalian behavior is the product neural circuits that generate robust and flexible patterns activity distributed across populations neurons. Decades associative studies have linked many behaviors to specific population activity, but association alone cannot reveal dynamical mechanisms shape those patterns. Are local high-dimensional reservoirs able arbitrary superpositions with appropriate excitation? Or might circuit dynamics be shaped in response behavioral context so as only low-dimensional needed for task at hand? Here, we address these questions within primate motor cortex by delivering optogenetic electrical microstimulation perturbations during reaching behavior. We develop a novel analytic approach relates measured theoretically tractable, models excitatory inhibitory This computational model captures effects demonstrates cortical self-contained, system. subspace containing task-relevant proves oriented strong non-normal amplification circuits. space exhibits privileged causal relationship behavior, stimulation perturb reach kinematics extent it alters states this subspace. Our results resolve long-standing about structure associated movement, illuminate perturbation experiments understand how throughout brain complex

Language: Английский

Citations

28
Brain mechanisms underlying catatonia: A systematic review DOI
Giulia Cattarinussi,

Alessio A. Gugliotta,

Dušan Hirjak

et al.

Schizophrenia Research, Journal Year: 2022, Volume and Issue: 263, P. 194 - 207

Published: Nov. 18, 2022

Language: Английский

Citations

27
Transition of distinct context-dependent ensembles from secondary to primary motor cortex in skilled motor performance DOI Creative Commons
Shin-Ichiro Terada, Kenta Kobayashi, M Matsuzaki

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 41(3), P. 111494 - 111494

Published: Oct. 1, 2022

When voluntary movements are executed under different contexts, context-dependent signals thought to weaken from secondary motor cortex (M2) primary (M1). However, it is unclear how the contexts processed M2 M1 execute skilled movement. We conduct two-photon calcium imaging of and in mice performing internally generated external-cue-triggered movements. Context dependency consistently high L2/3 neurons low pyramidal tract neurons. By contrast, context → axons increases as task performance improves. In addition, L2/3, but not axons, associated with fine-movement proficiency. The increase correlates stabilization population activity an that strongly encode contextual information. Thus, emergence distinct ensembles may be necessary for context-to-motor transformation facilitates performance.

Language: Английский

Citations

24
Input and Output Connections of the Crow Nidopallium Caudolaterale DOI Creative Commons

Ylva Kersten,

Felix W. Moll,

Saskia Erdle

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(4), P. ENEURO.0098 - 24.2024

Published: April 1, 2024

The avian telencephalic structure nidopallium caudolaterale (NCL) functions as an analog to the mammalian prefrontal cortex. In crows, corvid songbirds, it plays a crucial role in higher cognitive and executive functions. These rely on NCL's extensive connections. However, systematic investigations into brain-wide connectivity of NCL crows or other songbirds are lacking. Here, we studied its input output connections by injecting retrograde anterograde tracers carrion crow NCL. Our results, mapped onto published brain atlas, confirm multisensory extend prior pigeon findings identifying novel from hippocampal formation. Furthermore, analyze efferent projections arcopallium report newly identified arcopallial neurons projecting bilaterally help clarify central hub songbird brain.

Language: Английский

Citations

5
Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus DOI Creative Commons
James C. Dooley, Greta Sokoloff, Mark S. Blumberg

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(24), P. 5501 - 5511.e5

Published: Nov. 1, 2021

With our eyes closed, we can track a limb's moment-to-moment location in space. If this capacity relied solely on sensory feedback from the limb, would always be step behind because takes time: for execution of rapid and precise movements, such lags are not tolerable. Nervous systems solve problem by computing representations—or internal models—that mimic movements as they happening, with associated neural activity occurring after motor command but before feedback. Research adults indicates that cerebellum is necessary to compute models. What known, however, when—and under what conditions—this computational develops. Here, taking advantage unique kinematic features discrete, spontaneous limb twitches characterize active sleep, captured developmental emergence cerebellar-dependent model. Using rats at postnatal days (P) 12, P16, P20, compared ventral posterior (VP) lateral (VL) thalamic nuclei, both which receive somatosensory input only latter receives cerebellar input. At all ages, twitch-related VP lagged movement, consistent processing; similar was observed VL through P16. no longer movement instead precisely mimicked itself; depended In addition demonstrating models these findings implicate their development calibration through, least, preweanling period.

Language: Английский

Citations

31