Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner DOI Creative Commons
Vinícius Elias de Moura Oliveira,

I Bodea,

Julie Bakker

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Neuronal nitric oxide synthase (nNOS) neurons are ubiquitously spread in the rodent brain. Data using knockouts and pharmacology have revealed that nNOS is essential for display of sexual aggressive behavior. Yet, specific neuronal populations regulating those behaviors remain elusive. Here, we aimed to study role ventromedial hypothalamus (VMHvl)-nNOS social both sexes. First, evaluated whether expression overlaps with well-characterized estrogen receptor alpha (ERα+)-VMHvl population. Next, assessed how different stimuli affected VMHvl-nNOS neurons' activity. Lastly, used transgenic mice viral approaches ablate evaluate their impact on Our findings suggest constitute a small cluster within VMHvl-ERα+ population which regulates sex-specific manner. In males, seem be aggression whereas females behavior motivation.

Language: Английский

HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus DOI Creative Commons
Lukas Steuernagel, Brian Lam, Paul Klemm

et al.

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(10), P. 1402 - 1419

Published: Oct. 20, 2022

Language: Английский

Citations

151
An approximate line attractor in the hypothalamus encodes an aggressive state DOI Creative Commons
Aditya Nair, Tomomi Karigo, Bin Yang

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(1), P. 178 - 193.e15

Published: Jan. 1, 2023

The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA VMHvl, respectively. Here, we perform dynamical systems modeling population activity in these nuclei during behaviors. In unsupervised analysis identified a dominant dimension neural with large time constant (>50 s), generating an approximate line attractor state space. Progression the trajectory along this was correlated escalation agonistic behavior, suggesting that it may encode scalable aggressiveness. Consistent this, individual differences magnitude integration were strongly contrast, attractors not observed mating; instead, neurons fast dynamics tuned to actions. Thus, different hypothalamic employ distinct codes represent similar

Language: Английский

Citations

76
Hypothalamic control of innate social behaviors DOI
Long Mei, Takuya Osakada, Dayu Lin

et al.

Science, Journal Year: 2023, Volume and Issue: 382(6669), P. 399 - 404

Published: Oct. 26, 2023

Sexual, parental, and aggressive behaviors are central to the reproductive success of individuals species survival thus supported by hardwired neural circuits. The behavior control column (RBCC), which comprises medial preoptic nucleus (MPN), ventrolateral part ventromedial hypothalamus (VMHvl), ventral premammillary (PMv), is essential for all social behaviors. RBCC integrates diverse hormonal metabolic cues adjusts an animal's physical activity, hence chance encounters. further engages mesolimbic dopamine system maintain interest reinforces actions that time-locked with We propose brainstem form a dual-control generating moment-to-moment actions. This Review summarizes recent progress regarding identities cells their pathways drive different aspects

Language: Английский

Citations

45
Sexually dimorphic dopaminergic circuits determine sex preference DOI
Anqi Wei,

Anran Zhao,

Chaowen Zheng

et al.

Science, Journal Year: 2025, Volume and Issue: 387(6730)

Published: Jan. 9, 2025

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex remain unclear. In this study, we show that both male female mice exhibit but shift to when facing survival threats; their mediated by the dimorphic changes in excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. males, VTA projections nucleus accumbens (NAc) mediate preference, those medial preoptic preference. females, firing-pattern (phasic-like versus tonic-like) alteration -NAc projection determines sociosexual preferences. These findings define neurons as a key node decision-making reveal sexually circuit underlying

Language: Английский

Citations

6
VMHvllCckar cells dynamically control female sexual behaviors over the reproductive cycle DOI Creative Commons
Luping Yin, Koichi Hashikawa,

Yoshiko Hashikawa

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(18), P. 3000 - 3017.e8

Published: July 26, 2022

Language: Английский

Citations

50
Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus DOI Creative Commons
Brian R. Herb, Hannah J. Glover, Aparna Bhaduri

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(45)

Published: Nov. 8, 2023

The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. To address this, we integrated transcriptomic data from 241,096 cells (126,840 newly generated) prenatal adult to reveal a temporal trajectory proliferative stem cell populations mature hypothalamic types. Iterative clustering neurons identified 108 robust transcriptionally distinct representing 10 nuclei. Pseudotime trajectories provided insights into genes driving formation these Comparisons single-cell mouse suggested extensive conservation despite certain differences species-enriched gene expression. uniqueness lineages was examined developmentally by comparing excitatory present cortex inhibitory ganglionic eminence, revealing both shared drivers maturation across forebrain. These results provide comprehensive view through gestation adulthood at cellular resolution.

Language: Английский

Citations

34
Hyperexcited limbic neurons represent sexual satiety and reduce mating motivation DOI
Xiaojuan Zhou Et.Al, Ang Li, Xue Mi

et al.

Science, Journal Year: 2023, Volume and Issue: 379(6634), P. 820 - 825

Published: Feb. 9, 2023

Transient sexual experiences can have long-lasting effects on behavioral decisions, but the neural coding that accounts for this change is unclear. We found ejaculation experience selectively activated estrogen receptor 2 (Esr2)-expressing neurons in bed nucleus of stria terminalis (BNST)-BNSTEsr2-and led to persistent decreases firing threshold days, during which time mice displayed satiety. Inhibition hyperexcited BNSTEsr2 elicited fast mating recovery satiated both sexes. In males, such hyperexcitability reduced motivation and was partially mediated by larger HCN (hyperpolarization-activated cyclic nucleotide-gated) currents. Thus, not only encode a specific action also represent state satiety, alterations neuronal ion channel contribute experience-dependent long-term changes drive.

Language: Английский

Citations

33
Molecular and spatial profiling of the paraventricular nucleus of the thalamus DOI Creative Commons
Claire Gao, Chiraag Gohel, Yan Leng

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 3, 2023

The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked cellular differences, molecular identity spatial distribution cell types remain unclear. To address this gap, here we used single RNA sequencing (snRNA-seq) identified five molecularly distinct neuronal subtypes in mouse brain. Additionally, multiplex fluorescent situ hybridization top marker genes revealed that are organized by a combination previously unidentified gradients. Lastly, comparing our dataset with recently published single-cell atlas yielded novel insight into PVT’s connectivity cortex, including unexpected innervation auditory visual areas. This comparison also data contains largely non-overlapping transcriptomic map multiple midline thalamic nuclei. Collectively, findings uncover unknown features anatomical organization provide valuable resource for future investigations.

Language: Английский

Citations

24
Non-angry aggressive arousal and angriffsberietschaft: A narrative review of the phenomenology and physiology of proactive/offensive aggression motivation and escalation in people and other animals DOI Creative Commons
Michael Potegal, Jacob C. Nordman

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 147, P. 105110 - 105110

Published: Feb. 22, 2023

Human aggression typologies largely correspond with those for other animals. While there may be no non-human equivalent of angry reactive aggression, we propose that human proactive is similar to offense in animals' dominance contests territory or social status. Like predation/hunting, but unlike defense, and are positively reinforcing, involving dopamine release accumbens. The drive these motivational states provide must suffice overcome fear associated initiating risky fights. We term the neural activity motivating "non-angry aggressive arousal", use "angriffsberietschaft" motivation animals acknowledge possible differences. Temporal variation angriffsberietschaft partitions fights into bouts; engendering reduced anti-predator vigilance, redirected over-ride. Increased arousal drives threat-to-attack transitions, as verbal-to-physical escalation beyond that, hyper-aggression. Proactive involve related states. Cingulate, insular prefrontal cortices energize/modulate through a subcortical core containing subnuclei each type. These proposals will deepen understanding across taxa, guiding prevention/intervention violence.

Language: Английский

Citations

21
Neural control of female sexual behaviors DOI Creative Commons
Luping Yin, Dayu Lin

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 151, P. 105339 - 105339

Published: March 4, 2023

Language: Английский

Citations

19