At the onset of active whisking, the input layer of barrel cortex exhibits a 24 h window of increased excitability that depends on prior experience. DOI Creative Commons

Molly C. Shallow,

Lucy Tian,

Hudson Lin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Abstract The development of motor control over sensory organs is a critical milestone in processing, enabling active exploration and shaping the environment. However, whether onset organ directly influences corresponding cortices remains unknown. Here, we exploit late whisking behavior mice to address this question somatosensory system. Using ex vivo electrophysiology, discovered transient increase intrinsic excitability excitatory neurons layer IV barrel cortex, which processes whisker input, precisely coinciding with at postnatal day 14 (P14). This neuronal gain was specific IV, independent changes synaptic strength, required prior experience. Strikingly, effect not observed II/III cortex or visual upon eye opening, suggesting unique interaction between sensing thalamocortical input Predictive modeling indicated that membrane conductances alone could reliably distinguish P14 but whisker-deprived hemispheres. Our findings demonstrate an experience-dependent, lamina-specific refinement tightly linked emergence whisking. thalamic coincides period for plasticity downstream layers, role facilitating cortical maturation processing. Together, our results provide evidence direct offering new insights into experience-dependent systems. These have broad implications understanding interplay development, how mechanisms perception cooperate behavior.

Language: Английский

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits DOI Creative Commons
Yuniesky Andrade‐Talavera, André Fisahn, Antonio Rodríguez Moreno

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2177 - 2188

Published: March 29, 2023

Abstract In the mammalian brain information processing and storage rely on complex coding decoding events performed by neuronal networks. These actions are based computational ability of neurons their functional engagement in assemblies where precise timing action potential firing is crucial. Neuronal circuits manage a myriad spatially temporally overlapping inputs to compute specific outputs that proposed underly memory traces formation, sensory perception, cognitive behaviors. Spike-timing-dependent plasticity (STDP) electrical rhythms suggested underlie such functions while physiological evidence assembly structures mechanisms driving both processes continues be scarce. Here, we review foundational current precision cooperative activity STDP rhythms, interactions, emerging role glial cells processes. We also provide an overview correlates discuss limitations controversies, future perspectives experimental approaches, application humans.

Language: Английский

Citations

32
Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales DOI Creative Commons
Davide Crombie, Martin A. Spacek, Christian Leibold

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(5), P. e3002614 - e3002614

Published: May 14, 2024

The processing of sensory information, even at early stages, is influenced by the internal state animal. Internal states, such as arousal, are often characterized relating neural activity to a single “level” defined behavioral indicator pupil size. In this study, we expand understanding arousal-related modulations in systems uncovering multiple timescales dynamics and their relationship activity. Specifically, observed robust coupling between spiking mouse dorsolateral geniculate nucleus (dLGN) thalamus across spanning few seconds several minutes. Throughout all these timescales, 2 distinct modes—individual tonic spikes tightly clustered bursts spikes—preferred opposite phases dynamics. This multi-scale reveals from those captured size per se, locomotion, eye movements. Furthermore, persisted during viewing naturalistic movie, where it contributed differences encoding visual information. We conclude that dLGN under simultaneous influence processes associated with occurring over broad range timescales.

Language: Английский

Citations

10
Silences, spikes and bursts: Three‐part knot of the neural code DOI Creative Commons
Zachary Friedenberger, Emerson F. Harkin, Katalin Tóth

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(23), P. 5165 - 5193

Published: Oct. 27, 2023

When a neuron breaks silence, it can emit action potentials in number of patterns. Some responses are so sudden and intense that electrophysiologists felt the need to single them out, labelling emitted at particularly high frequency with metonym - bursts. Is there more bursts than figure speech? After all, bouts high-frequency firing expected occur whenever inputs surge. The burst coding hypothesis advances neural code has three syllables: silences, spikes We review evidence supporting this ternary terms devoted mechanisms for generation, synaptic transmission plasticity. also learning attention theories which such triad is beneficial.

Language: Английский

Citations

17
Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness DOI Creative Commons
Elaida Dimwamwa, Aurélie Pala, Vivek Chundru

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 25, 2024

The feedback projections from cortical layer 6 (L6CT) to the sensory thalamus have long been implicated in playing a primary role gating signaling but remain poorly understood. To causally elucidate full range of effects these projections, we targeted silicon probe recordings whisker thalamocortical circuit awake mice selectively expressing Channelrhodopsin-2 L6CT neurons. Through optogenetic manipulation neurons, multi-site electrophysiological recordings, and modeling circuitry, establish neurons as dynamic modulators ongoing spiking ventral posteromedial nucleus (VPm), either suppressing or enhancing VPm depending on neurons' firing rate synchrony. Differential across excitatory inhibitory sub-populations point an overall influence excitability that could profound implications for regulating ethologically relevant conditions.

Language: Английский

Citations

8
Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice DOI Creative Commons
Leslie D. Claar, Irene Rembado,

Jacqulyn R. Kuyat

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Feb. 9, 2023

Perturbational complexity analysis predicts the presence of consciousness in volunteers and patients by stimulating brain with brief pulses, recording EEG responses, computing their spatiotemporal complexity. We examined underlying neural circuits mice directly cortex while Neuropixels probes during wakefulness isoflurane anesthesia. When are awake, stimulation deep cortical layers reliably evokes locally a pulse excitation, followed biphasic sequence 120 ms profound off period rebound excitation. A similar pattern, partially attributed to burst spiking, is seen thalamic nuclei associated pronounced late component evoked EEG. infer that cortico-thalamo-cortical interactions drive long-lasting signals elicited awake state. The EEG, reduced running absent

Language: Английский

Citations

15
Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice DOI Creative Commons
Leslie D. Claar, Irene Rembado,

Jacqulyn R. Kuyat

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: June 26, 2023

Perturbational complexity analysis predicts the presence of consciousness in volunteers and patients by stimulating brain with brief pulses, recording EEG responses, computing their spatiotemporal complexity. We examined underlying neural circuits mice directly cortex while Neuropixels probes during wakefulness isoflurane anesthesia. When are awake, stimulation deep cortical layers reliably evokes locally a pulse excitation, followed biphasic sequence 120 ms profound off period rebound excitation. A similar pattern, partially attributed to burst spiking, is seen thalamic nuclei associated pronounced late component evoked EEG. infer that cortico-thalamo-cortical interactions drive long-lasting signals elicited awake state. The EEG, reduced running absent

Language: Английский

Citations

15
Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans DOI Creative Commons
Simone Russo, Leslie D. Claar,

Lydia Marks

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 2, 2024

Abstract Cortical stimulation with single pulses is a common technique in clinical practice and research. However, we still do not understand the extent to which it engages subcortical circuits contribute associated evoked potentials (EPs). Here find that cortical generates remarkably similar EPs humans mice, late component similarly modulated by subject’s behavioral state. We optogenetically dissect underlying circuit demonstrating of these caused thalamic hyperpolarization rebound. The magnitude this correlates bursting frequency synchronicity neurons, A simulation thalamo-cortical highlights both intrinsic currents as well GABAergic neurons response profile. conclude cortico-thalamo-cortical highly preserved across different species modalities. Graphical abstract

Language: Английский

Citations

4
Distributed burst activity in the thalamocortical system encodes reward contingencies during learning DOI Creative Commons
Filippo Heimburg,

Josephine Timm,

Nadin Mari Saluti

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Neuronal bursts are distinct high-frequency firing patterns that present ubiquitously throughout mammalian brain circuits. Although considered part of a universal neural code, the information they convey has long been subject debate. In this study, we investigated neuronal activity in simultaneously recorded regions thalamocortical system freely moving mice as learned stimulus-outcome associations go/no-go task. We discovered that, parallel with learning, populations neurons emerge cortical, thalamic, and extrathalamic somatosensory encode task-relevant stimulus features via presence or absence bursts. These burst-coder (BCNs) increase number task proficiency exhibit burstiness scales valence rather than physical identity. Notably, BCNs consistently track associations—even after multiple rule switches—by inverting their burst encoding stimuli, indicating coding is driven by outcome inherent properties. emerges system, only cortical units retain significant devaluation, while other lose discriminative patterns. Furthermore, decoding properties behavior achieves maximal accuracy when used input. Overall, these results provide direct experimental evidence linking bursting to supporting novel perspective context encoders teaching signals.

Language: Английский

Citations

0
Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes DOI Creative Commons
Sergey V. Stasenko, Victor Kazantsev

Entropy, Journal Year: 2023, Volume and Issue: 25(5), P. 745 - 745

Published: May 1, 2023

We investigated a mathematical model composed of spiking neural network (SNN) interacting with astrocytes. analysed how information content in the form two-dimensional images can be represented by an SNN spatiotemporal pattern. The includes excitatory and inhibitory neurons some proportion, sustaining excitation–inhibition balance autonomous firing. astrocytes accompanying each synapse provide slow modulation synaptic transmission strength. An image was uploaded to stimulation pulses distributed time reproducing shape image. found that astrocytic prevented stimulation-induced hyperexcitation non-periodic bursting activity. Such homeostatic regulation neuronal activity makes it possible restore supplied during lost raster diagram due At biological point, our shows act as additional adaptive mechanism for regulating activity, which is crucial sensory cortical representations.

Language: Английский

Citations

10
Impaired thalamic burst firing in Fragile X syndrome DOI Open Access
Ronan O’Shea, Nicholas J. Priebe, Darrin H. Brager

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract The thalamus performs a critical role in sensory processing by gating the flow of information to neocortex and directing sensory-driven behaviors; functions which are disrupted people with autism spectrum disorders (ASD). We have identified cellular changes thalamic neurons mouse model Fragile X syndrome (FX), leading monogenic cause ASD, that alter how transmits neocortical circuits. In awake animals, relay cells gate input shifting between two firing modes: burst tonic. Relay FX mice, however, do not shift these modes instead operate primarily tonic mode. demonstrate lack mode is caused voltage sensitivity for Ca 2+ -dependent low threshold spike, underlies normal firing.

Language: Английский

Citations

0