Neurocritical Care, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Language: Английский
Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(7), P. 508 - 524
Published: May 8, 2023
The rapid and coordinated propagation of neural activity across the brain provides foundation for complex behavior cognition. Technical advances neuroscience subfields have advanced understanding these dynamics, but points convergence are often obscured by semantic differences, creating silos subfield-specific findings. In this review we describe how a parsimonious conceptualization state as fundamental building block whole-brain offers common framework to relate findings scales species. We present examples diverse techniques commonly used study states associated with physiology higher-order cognitive processes, discuss integration them will enable more comprehensive mechanistic characterization dynamics that crucial survival disrupted in disease.
Language: Английский
Citations
84
Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(8), P. 1581 - 1598
Published: May 29, 2024
Abstract Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, causal contribution of specific patterns oscillatory activity within human striatum is unknown. To address this question, we exploited a recently developed non-invasive deep stimulation technique called transcranial temporal interference (tTIS) during reinforcement learning with concurrent neuroimaging, in randomized, sham-controlled, double-blind study. Striatal tTIS applied at 80 Hz, not 20 abolished benefits on learning. This effect was related to selective modulation neural striatum. Moreover, increased neuromodulatory influence frontal areas involved These results show that non-invasively and selectively modulate striatal mechanism expanding our tools for study relationships between structures behaviour.
Language: Английский
Citations
26
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 3, 2025
Over the past decade, research has shown that primary motor cortex (M1), brain's main output for movement, also responds to rewards. These reward signals may shape in its final stages, influencing movement invigoration and learning. In this Perspective, we highlight functional roles of M1 propose how they could guide advances neurotechnologies restoration, specifically brain-computer interfaces non-invasive brain stimulation. Understanding open new avenues enhancing control rehabilitation. The (M1) not only drives but authors discuss M1's transform like stimulation recovery.
Language: Английский
Citations
2
Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 156, P. 201 - 209
Published: Feb. 16, 2023
Language: Английский
Citations
37
Brain stimulation, Journal Year: 2023, Volume and Issue: 16(5), P. 1252 - 1258
Published: Aug. 17, 2023
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic therapy. In particular, the delivery of VNS paired with training to promote neural changes demonstrated clinical success for stroke recovery and found far-reaching application in other domains, from autism psychiatric disorders normal learning. The been extensively documented. Here, we consider more unusual question: why does have such broad utility, perhaps importantly, when not work? We present discussion concepts that underlie therapy an anthology studies describe conditions which these are violated fails. focus specifically on mechanisms engaged by implanted VNS, how parameters stimulation, method, pharmacological manipulations, accompanying comorbidities, specifics concurrent interact impact efficacy As is increasing translated implementation, clear understanding it does, critically, work fundamental this approach.
Language: Английский
Citations
27
Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(5), P. 259 - 268
Published: April 3, 2024
Language: Английский
Citations
17
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Feb. 17, 2024
Abstract Accurate senses depend on high-fidelity encoding by sensory receptors and error-free processing in the brain. Progress has been made towards restoring damaged receptors. However, methods for on-demand treatment of impaired central are scarce. Prior invasive studies demonstrated that continuous vagus nerve stimulation (VNS) rodents can activate locus coeruleus-norepinephrine system to rapidly improve processing. Here, we investigated whether transcutaneous VNS improves performance humans. We conducted three sham-controlled experiments, each with 12 neurotypical adults, measured effects metrics auditory visual performance, heart rate variability (HRV). Continuous was delivered cervical (tcVNS) or auricular (taVNS) branches while participants performed psychophysics tasks passively viewed a display. Relative sham stimulation, tcVNS improved 37% ( p = 0.00052) 23% 0.038). Participants lower during conditions experienced larger tcVNS-evoked improvements 0.0040). Lastly, increased HRV passive viewing, corroborating vagal engagement. No evidence an effect taVNS observed. These findings validate effectiveness humans position it as method interventions impairments associated dysfunction.
Language: Английский
Citations
15
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 13, 2024
Abstract Inflammation, caused by accumulation of inflammatory cytokines from immunocytes, is prevalent in a variety diseases. Electro-stimulation emerges as promising candidate for inhibition. Although electroacupuncture free surgical injury, it faces the challenges imprecise pathways/current spikes, and insufficiently defined mechanisms, while non-optimal pathway or spike would require high current amplitude, which makes electro-stimulation usually accompanied damage complications. Here, we propose neuromorphic based on atomically thin semiconductor floating-gate memory interdigital circuit. Direct stimulation achieved wrapping sympathetic chain with flexible electrodes are programmable to fire bionic thus minimizing nerve damage. A substantial decrease (73.5%) cytokine IL-6 occurred, also enabled better efficacy than commercial stimulator at record-low currents damage-free neurons. Additionally, using transgenic mice, anti-inflammation effect determined β2 adrenergic signaling myeloid cell lineage (monocytes/macrophages granulocytes).
Language: Английский
Citations
14
Comprehensive Psychiatry, Journal Year: 2024, Volume and Issue: 132, P. 152488 - 152488
Published: April 16, 2024
Major depressive disorder (MDD) is often marked by impaired motivation and reward processing, known as anhedonia. Many patients do not respond to first-line treatments, improvements in can be slow, creating an urgent need for rapid interventions. Recently, we demonstrated that transcutaneous auricular vagus nerve stimulation (taVNS) acutely boosts effort invigoration healthy participants, but its effects on depression remain unclear.
Language: Английский
Citations
12
Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Feb. 21, 2024
The Deep Brain Stimulation (DBS) Think Tank XI was held on August 9–11, 2023 in Gainesville, Florida with the theme of “Pushing Forefront Neuromodulation”. keynote speaker Dr. Nico Dosenbach from Washington University St. Louis, Missouri. He presented his research recently published Nature inn a collaboration Evan Gordon to identify and characterize somato-cognitive action network (SCAN), which has redefined motor homunculus led new hypotheses about integrative networks underpinning therapeutic DBS. DBS founded 2012 provides an open platform where clinicians, engineers, researchers (from industry academia) can freely discuss current emerging technologies, as well logistical ethical issues facing field. group estimated that globally more than 263,000 devices have been implanted for neurological neuropsychiatric disorders. This year's meeting focused advances following areas: cutting-edge translational neuromodulation, physiology, neuromodulation Europe Asia, neuroethical dilemmas, artificial intelligence computational modeling, time scales mood disorders, future devices.
Language: Английский
Citations
10