Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective DOI Creative Commons
Jaerin Sohn

Anatomical Science International, Journal Year: 2023, Volume and Issue: 99(1), P. 17 - 33

Published: Oct. 14, 2023

Abstract Brain computation relies on the neural networks. Neurons extend neurites such as dendrites and axons, contacts of these that form chemical synapses are biological basis signal transmissions in central nervous system. Individual neuronal outputs can influence other neurons within range axonal spread, while activities single be affected by afferents their somatodendritic fields. The morphological profile, therefore, binds functional role each neuron play. In addition, synaptic connectivity among displays preference based characteristics presynaptic postsynaptic neurons. Here, author reviews “spatial” “temporal” connection selectivity neocortex. histological description neocortical circuitry depends primarily classification cell types, development gene engineering techniques allows type-specific visualization axons well somata. Using genetic labeling particular populations combined with immunohistochemistry imaging at a subcellular spatial resolution, we revealed “spatial selectivity” cortical wirings which non-uniformly distributed domains manner. dynamics learning exhibit type-dependent “temporal selectivity”: corticocortical appear only transiently during phase, learning-induced new thalamocortical persist, indicating distinct circuits may supervise learning-specific ephemeral synapse memory-specific immortal formation. configuration temporal reconfiguration govern diverse functions

Language: Английский

The proteomic landscape of synaptic diversity across brain regions and cell types DOI Creative Commons
Marc van Oostrum, Thomas M. Blok, Stefano L. Giandomenico

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(24), P. 5411 - 5427.e23

Published: Nov. 1, 2023

Neurons build synaptic contacts using different protein combinations that define the specificity, function, and plasticity potential of synapses; however, diversity proteomes remains largely unexplored. We prepared synaptosomes from 7 transgenic mouse lines with fluorescently labeled presynaptic terminals. Combining microdissection 5 brain regions fluorescent-activated synaptosome sorting (FASS), we isolated analyzed 18 synapse types. discovered ∼1,800 unique synapse-type-enriched proteins allocated thousands to types synapses (https://syndive.org/). identify shared modules highlight proteomic hotspots for specialization. reveal common features striatal dopaminergic proteome discover signatures relate functional properties interneuron classes. This study provides a molecular systems-biology analysis framework integrate information subtypes interest cellular or circuit-level experiments.

Language: Английский

Citations

55
How deep is the brain? The shallow brain hypothesis DOI
Mototaka Suzuki, Cyriel M. A. Pennartz, Jaan Aru

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 778 - 791

Published: Oct. 27, 2023

Language: Английский

Citations

40
Layer 1 NDNF interneurons are specialized top-down master regulators of cortical circuits DOI Creative Commons
Jan Hartung, Anna Schroeder,

Rodrigo Alejandro Péréz Vázquez

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(5), P. 114212 - 114212

Published: May 1, 2024

Diverse types of inhibitory interneurons (INs) impart computational power and flexibility to neocortical circuits. Whereas markers for different IN in cortical layers 2-6 (L2-L6) have been instrumental generating a wealth functional insights, only the recent identification selective marker (neuron-derived neurotrophic factor [NDNF]) has opened comparable opportunities INs L1 (L1INs). However, at present we know very little about connectivity NDNF L1INs with other types, their input-output conversion, existence potential L1IN subtypes. Here, report pervasive inhibition L2/3 (including parvalbumin vasoactive intestinal peptide INs) by L1INs. Intersectional genetics revealed similar physiology subpopulation co-expressing neuropeptide Y. Finally, prominently selectively engage persistent firing, physiological hallmark disconnecting output from current input. Collectively, our work therefore identifies as specialized master regulators superficial neocortex according top-down afferents.

Language: Английский

Citations

12
Layer 1 neocortex: Gating and integrating multidimensional signals DOI Creative Commons
Shuhan Huang, Jingjing Sherry Wu, Giulia Sansone

et al.

Neuron, Journal Year: 2023, Volume and Issue: 112(2), P. 184 - 200

Published: Oct. 31, 2023

Language: Английский

Citations

14
The proteomic landscape of synaptic diversity across brain regions and cell types DOI Creative Commons
Marc van Oostrum, Thomas M. Blok, Stefano L. Giandomenico

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 27, 2023

Abstract Brain function relies on communication via neuronal synapses. Neurons build and diversify synaptic contacts using different protein combinations that define the specificity, plasticity potential of More than a thousand proteins have been globally identified in both pre- postsynaptic compartments, providing substantial for diversity. While there is ample evidence diverse structures, states or functional properties, diversity underlying individual proteomes remains largely unexplored. Here we used 7 Cre-driver mouse lines crossed with floxed line which presynaptic terminals were fluorescently labeled (SypTOM) to identify underlie We combined microdissection 5 brain regions fluorescent-activated synaptosome sorting isolate analyze quantitative mass spectrometry 18 types synapses their proteomes. discovered ~1’800 unique synapse type-enriched allocated thousands commonly shared modules highlight hotspots proteome specialization. A protein-protein correlation network classifies into association traits reveals communities correlate either neurotransmitter glutamate GABA. Finally, reveal specializations commonalities striatal dopaminergic outline formed by parvalbumin, somatostatin vasoactive intestinal peptide-expressing cortical interneuron subtypes, highlighting signatures relate properties. This study opens door molecular systems-biology analysis provides framework integrate proteomic information subtypes interest cellular circuit-level experiments.

Language: Английский

Citations

13
Local and long-range GABAergic circuits in hippocampal area CA1 and their link to Alzheimer’s disease DOI Creative Commons
Melissa Hernández‐Frausto, Olesia M. Bilash, Arjun V. Masurkar

et al.

Frontiers in Neural Circuits, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 29, 2023

GABAergic inhibitory neurons are the principal source of inhibition in brain. Traditionally, their role maintaining balance excitation-inhibition has been emphasized. Beyond homeostatic functions, recent circuit mapping and functional manipulation studies have revealed a wide range specific roles that circuits play dynamically tilting coupling across spatio-temporal scales. These span from gating compartment- input-specific signaling, gain modulation, shaping input–output functions synaptic plasticity, to generating signal-to-noise contrast, defining temporal windows for integration rate codes, as well organizing neural assemblies, coordinating inter-regional synchrony. thus instrumental controlling single-neuron computations behaviorally-linked network activity. The activity dependent modulation sensory mnemonic information processing by is pivotal formation maintenance episodic memories hippocampus. Here, we present an overview local long-range modulate dynamics disinhibition main output area hippocampus CA1, which crucial memory. Specifically, link findings pertaining neuron molecular markers, electrophysiological properties, wiring with function at level. Lastly, given CA1 particularly impaired during early stages Alzheimer’s disease, emphasize how these may contribute be involved pathophysiology.

Language: Английский

Citations

12
Disentangling the identity of the zona incerta: a review of the known connections and latest implications DOI Creative Commons

Giulia Arena,

Fabrizio Londei, Francesco Ceccarelli

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102140 - 102140

Published: Nov. 24, 2023

The zona incerta (ZI) is a subthalamic region composed by loosely packed neurochemically mixed neurons, juxtaposed to the main ascending and descending bundles. extreme neurochemical diversity that characterizes this area, together with diffuseness of its connections entire neuraxis hard-to-reach positioning in brain caused ZI keep halo mystery for over century. However, last decades, rich albeit fragmentary body knowledge regarding both incertal anatomical functional implications has been built mostly based on rodent studies lack cohesion makes difficult depict an integrated, exhaustive picture roles. This review aims provide unified resource summarizes current profile interactions rodents non-human primates significance connections, highlighting aspects still unbeknown research.

Language: Английский

Citations

12
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors DOI Creative Commons

Mengyue Zhu,

Jieqiao Peng,

Mi Wang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 1, 2025

Language: Английский

Citations

0
Somatostatin neurons detect stimulus-reward contingencies to reduce neocortical inhibition during learning DOI
Eunsol Park, Dika Kuljis,

Rachel A Swindell

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115606 - 115606

Published: April 20, 2025

Language: Английский

Citations

0
Concerning neuromodulation as treatment of neurological and neuropsychiatric disorder: Insights gained from selective targeting of the subthalamic nucleus, para-subthalamic nucleus and zona incerta in rodents DOI Creative Commons
Alessia Ricci, E. Rubino, Gian Pietro Serra

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 256, P. 110003 - 110003

Published: May 22, 2024

Neuromodulation such as deep brain stimulation (DBS) is advancing a clinical intervention in several neurological and neuropsychiatric disorders, including Parkinson's disease, dystonia, tremor, obsessive-compulsive disorder (OCD) for which DBS already applied to alleviate severely afflicted individuals of symptoms. Tourette syndrome drug addiction are two additional disorders trial or proposed treatment. However, some major remaining obstacles prevent this from reaching its full therapeutic potential. Side-effects have been reported, not all DBS-treated relieved their One target area electrodes the subthalamic nucleus (STN) plays important roles motor, affective associative functions, with impact on example movement, motivation, impulsivity, compulsivity, well both reward aversion. The multifunctionality STN complex. Decoding anatomical-functional organization could enhance strategic targeting human patients. located close proximity zona incerta (ZI) para-subthalamic (pSTN). Together, STN, pSTN ZI form highly heterogeneous clinically area. Rodent-based experimental studies, opto- chemogenetics viral-genetic tract tracings, provide unique insight into complex neuronal circuitries behavior high spatial temporal precision. This research field has advanced tremendously over past few years. Here, we an inclusive review current literature pre-clinical fields centered around laboratory mice rats; three enigmatic structures brought together context relevance treatment strategies. Specific emphasis placed methods manipulation behavioral impact.

Language: Английский

Citations

3