The Neuropsychology of Anxiety

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Language: Английский

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Associative and predictive hippocampal codes support memory-guided behaviors

Science, Journal Year: 2023, Volume and Issue: 382(6668)

Published: Oct. 19, 2023

Episodic memory involves learning and recalling associations between items their spatiotemporal context. Those memories can be further used to generate internal models of the world that enable predictions made. The mechanisms support these associative predictive aspects are not yet understood. In this study, we an optogenetic manipulation perturb sequential structure, but global network dynamics, place cells as rats traversed specific spatial trajectories. This perturbation abolished replay those trajectories development representations, leading impaired new optimal during memory-guided navigation. However, cell assembly reactivation reward-context were unaffected. Our results show a mechanistic dissociation two complementary hippocampal codes: code (through coactivity) sequences).

Language: Английский

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Consciousness and sleep

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1568 - 1594

Published: May 1, 2024

Language: Английский

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Sleep microstructure organizes memory replay

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Temporal context and latent state inference in the hippocampal splitter signal

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 9, 2023

The hippocampus is thought to enable the encoding and retrieval of ongoing experience, organization that experience into structured representations like contexts, maps, schemas, use these structures plan for future. A central goal understand what core computations supporting functions are, how are realized in collective action single neurons. potential access point this issue provided by ‘splitter cells’, hippocampal neurons fire differentially on overlapping segment trajectories differ their past and/or However, literature splitter cells has been fragmented confusing, owing differences terminology, behavioral tasks, analysis methods across studies. In review, we synthesize consistent findings from literature, establish a common set terms, translate between single-cell ensemble perspectives. Most importantly, examine combined through lens two major theoretical ideas about function: representation temporal context latent state inference. We find unique signature properties each models necessary account data, but neither theory, itself, explains all its features. Specifically, gradedness signal strong support context, hard explain using models, while flexibility task-dependence naturally accounted inference, poses challenge otherwise. These theories suggest number avenues future work, believe application timely informative domain testing refining function.

Language: Английский

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The role of the hippocampus in the consolidation of emotional memories during sleep

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(11), P. 912 - 925

Published: Sept. 14, 2023

Language: Английский

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A hippocampal circuit mechanism to balance memory reactivation during sleep

Science, Journal Year: 2024, Volume and Issue: 385(6710), P. 738 - 743

Published: Aug. 15, 2024

Memory consolidation involves the synchronous reactivation of hippocampal cells active during recent experience in sleep sharp-wave ripples (SWRs). How this increase firing rates and synchrony after learning is counterbalanced to preserve network stability not understood. We discovered a event generated by an intrahippocampal circuit formed subset CA2 pyramidal cholecystokinin-expressing (CCK+) basket cells, which fire barrage action potentials (“BARR”) non–rapid eye movement sleep. CA1 neurons assemblies that increased their activity were reactivated SWRs but inhibited BARRs. The initial returned baseline through This trend was abolished silencing CCK+ BARRs, resulting higher impaired memory consolidation.

Language: Английский

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Amygdalo-cortical dialogue underlies memory enhancement by emotional association

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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The generative grammar of the brain: a critique of internally generated representations

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 25(1), P. 60 - 75

Published: Nov. 30, 2023

Language: Английский

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Months-long tracking of neuronal ensembles spanning multiple brain areas with Ultra-Flexible Tentacle Electrodes

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 6, 2024

Abstract We introduce Ultra-Flexible Tentacle Electrodes (UFTEs), packing many independent fibers with the smallest possible footprint without limitation in recording depth using a combination of mechanical and chemical tethering for insertion. demonstrate scheme to implant UFTEs simultaneously into brain areas at arbitrary locations angle-of-insertion limitations, 512-channel wireless logger. Immunostaining reveals no detectable chronic tissue damage even after several months. Mean spike signal-to-noise ratios are 1.5-3x compared state-of-the-art, while highest reach 89, average cortical unit yields ~1.75/channel. can track same neurons across sessions least 10 months (longest duration tested). tracked inter- intra-areal neuronal ensembles (neurons repeatedly co-activated within 25 ms) from hippocampus, retrosplenial cortex, medial prefrontal cortex freely moving rodents. Average ensemble lifetimes were shorter than durations over which we individual neurons. identify two distinct classes ensembles. Those tuned sharp-wave ripples display shortest lifetimes, members mostly hippocampal. Yet, inter-areal both hippocampus have weak tuning sharp wave ripples, some unusual months-long lifetimes. Such occasionally remain inactive weeks before re-emerging.

Language: Английский

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