Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105835 - 105835
Published: July 29, 2024
Language: Английский
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)
Published: Feb. 20, 2024
Sex plays a crucial role in human brain development, aging, and the manifestation of psychiatric neurological disorders. However, our understanding sex differences functional organization their behavioral consequences has been hindered by inconsistent findings lack replication. Here, we address these challenges using spatiotemporal deep neural network (stDNN) model to uncover latent dynamics that distinguish male female brains. Our stDNN accurately differentiated brains, demonstrating consistently high cross-validation accuracy (>90%), replicability, generalizability across multisession data from same individuals three independent cohorts (N ~ 1,500 young adults aged 20 35). Explainable AI (XAI) analysis revealed features associated with default mode network, striatum, limbic exhibited significant (effect sizes > 1.5) sessions cohorts. Furthermore, XAI-derived predicted sex-specific cognitive profiles, finding was also independently replicated. results demonstrate are not only highly replicable generalizable but behaviorally relevant, challenging notion continuum male-female organization. underscore as biological determinant organization, have implications for developing personalized biomarkers disorders, provide innovative AI-based computational tools future research.
Language: Английский
Citations
26
Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(3), P. 1205 - 1263
Published: March 14, 2024
Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.
Language: Английский
Citations
26
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
3
Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Metaverse integrates people into the virtual world, and challenges depend on advances in human, technological, procedural dimensions. Until now, solutions to these have not involved extensive neurosociological research. The study explores pioneering paradigm metaverse, emphasizing its potential revolutionize our understanding of social interactions through advanced methodologies such as hyperscanning interbrain synchrony. This convergence presents unprecedented opportunities for neurotypical neurodivergent individuals due technology personalization. Traditional face-to-face, coupling, metaverse are empirically substantiated. Biomarkers interaction feedback between brain networks is presented. innovative contribution findings broader literature neurosociology article also discusses ethical aspects integrating metaverse.
Language: Английский
Citations
2
Expert Review of Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
Frontotemporal dementia (FTD) encompasses a group of heterogeneous neurodegenerative disorders. Aside from genetic cases, its diagnosis is challenging, particularly in the early stages when symptoms are ambiguous, and structural neuroimaging does not reveal characteristic patterns. The authors performed comprehensive literature search through MEDLINE, Scopus, Web Science databases to gather evidence aid diagnostic process for suspected FTD patients, phases, even sporadic ranging established promising tools. Blood-based biomarkers might help identify very neuropathological guide further evaluations. Subsequently, neurophysiological measures reflecting functional changes cortical excitatory/inhibitory circuits, along with assessing brain network, connectivity, metabolism, perfusion alterations, could detect specific associated decades before symptom onset. As advances, cognitive-behavioral profiles atrophy patterns emerge, distinguishing subtypes. Emerging disease-modifying therapies require patient enrollment. Therefore, paradigm shift needed - relying on typical cognitive advanced cases widely applicable biomarkers, primarily fluid and, subsequently, where appropriate. Additionally, exploring subjective complaints behavioral detected by home-based technologies be crucial diagnosis.
Language: Английский
Citations
2
Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(7), P. 787 - 800
Published: June 6, 2024
Abstract Altered functional connectivity precedes structural brain changes and symptoms in dementia. Alzheimer’s disease is the largest contributor to dementia at population level, disrupts brain’s default-mode network (DMN). We investigated whether a neurobiological model of DMN effective could predict future diagnosis single-participant level. applied spectral dynamic causal modeling resting-state magnetic resonance imaging data nested case–control group from UK Biobank, including 81 undiagnosed individuals who developed up nine years after imaging, 1,030 matched controls. Dysconnectivity predicted both incidence (AUC = 0.82) time ( R 0.53), outperforming models based on structure connectivity. also evaluated associations between dysconnectivity major risk factors for dementia, revealing strong relationships with polygenic social isolation. Neurobiological may facilitate early detection supporting rational deployment targeted dementia-prevention strategies.
Language: Английский
Citations
15
Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(745)
Published: May 1, 2024
Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness human brain, but knowledge about subcortical sustain humans incomplete. Here, we aimed to map connectivity a proposed network sustains wakefulness analogous default mode (DMN) shown contribute We integrated data from ex vivo diffusion magnetic resonance imaging (MRI) three brains, obtained at autopsy neurologically normal individuals, with immunohistochemical staining brain sections. identified nodes ascending (dAAN) brainstem, hypothalamus, thalamus, basal forebrain. Deterministic probabilistic tractography analyses MRI revealed projection, association, commissural pathways linking dAAN one another DMN nodes. Complementary 7-tesla resting-state functional Human Connectome Project dopaminergic ventral tegmental area midbrain as widely connected hub node nexus networks. Our network-based methods provide putative neuroanatomic architecture for integration consciousness.
Language: Английский
Citations
14
Brain, Journal Year: 2024, Volume and Issue: 147(10), P. 3409 - 3425
Published: June 18, 2024
Abstract The default mode network (DMN) is a widely distributed, intrinsic brain thought to play crucial role in internally directed cognition. present study employs stereo-EEG 13 human patients, obtaining high resolution neural recordings across multiple canonical DMN regions during two processes that have been associated with creative thinking: spontaneous and divergent thought. We probe these DMN-associated higher cognitive functions through mind wandering alternate uses tasks, respectively. Our results reveal recruitment both as well task-specific dissociation spatiotemporal response dynamics. When compared the fronto-parietal network, activity was characterized by stronger increase gamma band power (30–70 Hz) coupled lower theta (4–8 Hz). difference between networks especially strong task. Within DMN, we found tasks showed different dynamics, task engaging more initial stage of task, later stage. Gamma changes were mainly driven lateral sites, while displayed effects. During did not show spatial differences within an early late dorsomedial engagement. Furthermore, causal manipulations using direct cortical stimulation preferentially decreased originality responses alternative without affecting fluency or wandering. suggest flexibly modulated function specific supports its thinking. These findings shed light on constructs supporting forms cognition provide evidence for generation original connections among concepts.
Language: Английский
Citations
14
Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(8), P. 593 - 607
Published: July 24, 2024
Language: Английский
Citations
14
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 131, P. 110952 - 110952
Published: Jan. 26, 2024
Thoughts and moods constituting our mental life incessantly change. When the steady flow of this dynamics diverges in clinical directions, possible pathways involved are captured through discrete diagnostic labels. Yet a single vulnerable neurocognitive system may be causally psychopathological deviations transdiagnostically. We argue that language viewed as integrating cortical functions is best current candidate, whose forms breakdown along its different dimensions then manifest symptoms – from prosodic abnormalities rumination depression to distortions speech perception verbal hallucinations, meaning content delusions, or disorganized formal thought disorder. Spontaneous connected provides continuous objective readouts generating highly accessible bio-behavioral marker with potential revolutionizing neuropsychological measurement. This argument turns into transdiagnostic ‘L-factor’ providing an analytical mechanistic substrate for previously proposed latent general factors psychopathology (‘p-factor’) cognitive functioning (‘c-factor’). Together immense practical opportunities afforded by rapidly advancing natural processing (NLP) technologies abundantly available data, suggests new era translational psychiatry, which both rethought together.
Language: Английский
Citations
11