Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms

PLoS Computational Biology, Journal Year: 2023, Volume and Issue: 19(10), P. e1011465 - e1011465

Published: Oct. 17, 2023

This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies essential (axioms), infers necessary and sufficient that its substrate must satisfy (postulates), expresses them mathematical In principle, postulates can be applied any system units a state determine whether it is conscious, what degree, way. offers parsimonious explanation empirical evidence, makes testable predictions concerning both presence quality experience, permits inferences extrapolations. 4.0 incorporates several developments past ten years, including more accurate formulation axioms as expressions, introduction unique measure intrinsic information consistent with postulates, an explicit assessment causal relations. By fully unfolding system's irreducible cause-effect power, distinctions relations specified by experience.

Language: Английский

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An adversarial collaboration to critically evaluate theories of consciousness

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Summary Different theories explain how subjective experience arises from brain activity 1,2 . These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field 3 Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT) 4,5 Global Neuronal Workspace (GNWT) 6–10 , employing a theory-neutral consortium approach 11,12 We investigate neural correlates of content duration visual experience. The theory proponents developed preregistered experimental design, divergent predictions, expected outcomes, their interpretation 12 256 human subjects viewed suprathreshold stimuli for variable durations while was measured with functional magnetic resonance imaging, magnetoencephalography, electrocorticography. find information about conscious visual, ventro-temporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early areas. results confirm some predictions IIT GNWT, substantially challenging both theories: IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. Beyond themselves, alternative to advance cognitive neuroscience through principled, theory-driven, collaborative effort. highlight challenges change people’s mind 13 need quantitative framework integrating evidence systematic testing building.

Language: Английский

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Consciousness and sleep

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1568 - 1594

Published: May 1, 2024

Language: Английский

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Consciousness or pseudo-consciousness? A clash of two paradigms

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

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An adversarial collaboration to critically evaluate theories of consciousness

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: June 28, 2023

Abstract Different theories explain how subjective experience arises from brain activity1,2. These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field3. Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT)4,5 Global Neuronal Workspace (GNWT)6-10, employing a theory-neutral consortium approach11,12. We investigate neural correlates of content duration visual experience. The theory proponents developed preregistered experimental design, divergent predictions, expected outcomes, their interpretation12. 256 human subjects viewed suprathreshold stimuli for variable durations while activity was measured with functional magnetic resonance imaging, magnetoencephalography, electrocorticography. find information about conscious visual, ventro-temporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early areas. results confirm some predictions IIT GNWT, substantially challenging both theories: IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. Beyond themselves, alternative approach to advance cognitive neuroscience through principled, theory-driven, collaborative effort. highlight challenges change people’s mind 13 need quantitative framework integrating evidence systematic testing building.

Language: Английский

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The Brain/MINDS Marmoset Connectivity Resource: An open-access platform for cellular-level tracing and tractography in the primate brain

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(6), P. e3002158 - e3002158

Published: June 29, 2023

The primate brain has unique anatomical characteristics, which translate into advanced cognitive, sensory, and motor abilities. Thus, it is important that we gain insight on its structure to provide a solid basis for models will clarify function. Here, report the implementation features of Brain/MINDS Marmoset Connectivity Resource (BMCR), new open-access platform provides access high-resolution anterograde neuronal tracer data in marmoset brain, integrated retrograde tractography data. Unlike other existing image explorers, BMCR allows visualization from different individuals modalities common reference space. This feature, allied an unprecedented high resolution, enables analyses such as reciprocity, directionality, spatial segregation connections. present release focuses prefrontal cortex (PFC), uniquely developed region linked cognition, including results 52 164 injections marmoset. Moreover, inclusion diffusion MRI systematic this noninvasive modality against gold-standard cellular connectivity data, enabling detection false positives negatives, future development tractography. paper introduces preprocessing pipeline resources, include tools exploring reviewing

Language: Английский

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Noninvasive focal transgene delivery with viral neuronal tracers in the marmoset monkey

Cell Reports Methods, Journal Year: 2024, Volume and Issue: 4(2), P. 100709 - 100709

Published: Feb. 1, 2024

We establish a reliable method for selectively delivering adeno-associated viral vectors (AAVs) across the blood-brain barrier (BBB) in marmoset without need neurosurgical injection. focally perturbed BBB (∼1 × 2 mm) area 8aD of frontal cortex four adult monkeys using low-intensity transcranial focused ultrasound aided by microbubbles. Within an hour opening BBB, either AAV2 or AAV9 was delivered systemically via tail-vein In all marmosets, fluorescence-encoded neurons were observed at site perturbation, with showing sparse distribution transduced when compared to AAV9. The results are direct intracortical injections anterograde tracers into and similar (albeit sparser) long-range connectivity observed. With evidence specific region as well long-distance tracing, we framework focal noninvasive transgene delivery brain.

Language: Английский

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Common marmoset: An emerging non-human primate model for translational applications in brain disorders

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 92, P. 102998 - 102998

Published: March 15, 2025

Language: Английский

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Frontal-auditory cortical interactions and sensory prediction during vocal production in marmoset monkeys

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

The control of speech and vocal production involves the calculation error between intended output resulting auditory feedback. This model has been supported by evidence that cortex (AC) is suppressed immediately before during yet remains sensitive to differences altered suppression suggested be result top-down signals about output, potentially originating from frontal cortical (FC) areas. However, whether FC source suppressive predictive signaling AC vocalization unknown. Here, we simultaneously recorded neural activity both marmoset monkeys self-initiated vocalizations. We found increases in brain areas 1 0.5 s (early pre-vocal period), specifically changes multi-unit theta-band power. Connectivity analysis using Granger causality demonstrated sends directed this early period. Importantly, correlated with vocalization-induced as well structure acoustics subsequent calls, such fundamental frequency. Furthermore, bidirectional auditory-frontal interactions emerged experimentally feedback predicted compensatory behavior. These results suggest communicates production, frontal-to-auditory may reflect transmission sensory prediction information suggestive detection could drive feedback-dependent control.

Language: Английский

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Arcuate Fasciculus: Evolutionary Convergence in Marmosets and Humans

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract The marmoset is a highly vocal platyrrhine monkey that shares key anatomical and functional features with humans, providing unique opportunity to illuminate the phylogenetic origins of diverging connectivity profiles their transformations throughout evolution. Although similarity vocalization between humans has been reported, whether marmosets possess an arcuate fasciculus homolog not known. In this study, we delineated white matter tracts in marmosets, establishing homologies those observed other primates, including macaques, chimpanzees, humans. presence was confirmed by tracer ultra-high-resolution diffusion magnetic resonance imaging datasets. Using blueprint approach, compared cortical patterns across these species found terminates ventral frontal cortex, exceeds something corroborated quantitative analyses after transforming all brains into common space. To explore fasciculus’ support for species-specific vocalizations, activation communications were associated connectivity. Collectively, our findings suggest dorsal pathway, which emerged early evolution, evolved convergently despite distant kindship.

Language: Английский

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