Integrated information theory reveals the potential role of the posterior parietal cortex in sustaining conditioning responses in classical conditioning tasks DOI Creative Commons

Tien Cuong Phi,

Shin Ishii, Masashi Kondo

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 29, 2025

Classical conditioning is a fundamental associative learning process in which repeated pairings of conditioned stimulus (CS) with an unconditioned (US) lead to the CS eliciting response (CR). Previous research has identified key neural regions involved processing reward-predicting cues and mediating licking behavior. However, mechanisms that sustain high rates across sessions remain elusive, particularly regarding how reward expectation represented on session-by-session basis. While early phases classical have been extensively studied, support consistent performance over time unclear. In this study, we sought understand cortical regions, posterior parietal cortex (PPC), contribute maintaining CR sessions. Using core complex framework derived from Integrated Information Theory (IIT), explored dynamics networks during performance. Our findings suggest while traditional functional connectivity (FC) methods struggled capture complexity sustained behavioral engagement, revealed notably PPC, were significantly correlated enhanced This work suggests potential role PPC supporting expectations responses. By applying investigate substrates behavior, provide novel insights into interaction conditioning, offering promising directions for future

Language: Английский

An adversarial collaboration to critically evaluate theories of consciousness DOI Creative Commons
Oscar Ferrante, Urszula Górska, Simon Henin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Summary Different theories explain how subjective experience arises from brain activity 1,2 . These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field 3 Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT) 4,5 Global Neuronal Workspace (GNWT) 6–10 , employing a theory-neutral consortium approach 11,12 We investigate neural correlates of content duration visual experience. The theory proponents developed preregistered experimental design, divergent predictions, expected outcomes, their interpretation 12 256 human subjects viewed suprathreshold stimuli for variable durations while was measured with functional magnetic resonance imaging, magnetoencephalography, electrocorticography. find information about conscious visual, ventro-temporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early areas. results confirm some predictions IIT GNWT, substantially challenging both theories: IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. Beyond themselves, alternative to advance cognitive neuroscience through principled, theory-driven, collaborative effort. highlight challenges change people’s mind 13 need quantitative framework integrating evidence systematic testing building.

Language: Английский

Citations

50
An integrative, multiscale view on neural theories of consciousness DOI Creative Commons
Johan F. Storm, P. Christiaan Klink, Jaan Aru

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1531 - 1552

Published: March 5, 2024

How is conscious experience related to material brain processes? A variety of theories aiming answer this age-old question have emerged from the recent surge in consciousness research, and some are now hotly debated. Although most researchers so far focused on development validation their preferred theory relative isolation, article, written by a group scientists representing different theories, takes an alternative approach. Noting that various often try explain aspects or mechanistic levels consciousness, we argue do not necessarily contradict each other. Instead, several them may converge fundamental neuronal mechanisms be partly compatible complementary, multiple can simultaneously contribute our understanding. Here, consider unifying, integration-oriented approaches been largely neglected, seeking combine valuable elements theories.

Language: Английский

Citations

35
Consciousness and sleep DOI
Giulio Tononi, Mélanie Boly, Chiara Cirelli

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1568 - 1594

Published: May 1, 2024

Language: Английский

Citations

20
Anesthesia and the neurobiology of consciousness DOI
George A. Mashour

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1553 - 1567

Published: April 4, 2024

Language: Английский

Citations

17
What makes a theory of consciousness unscientific? DOI
Michał Klincewicz, Tony Cheng, Michael Schmitz

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

2
A synergistic workspace for human consciousness revealed by Integrated Information Decomposition DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 25, 2023

How is the information-processing architecture of human brain organised, and how does its organisation support consciousness? Here, we combine network science a rigorous information-theoretic notion synergy to delineate ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across brain. This then integrated within workspace widely distributed via broadcaster regions. Through functional MRI analysis, show correspond brain’s default mode network, whereas broadcasters coincide with executive control network. We find loss consciousness due general anaesthesia or disorders corresponds diminished ability integrate information, which restored upon recovery. Thus, coincides breakdown integration work contributes conceptual empirical reconciliation between two prominent scientific theories consciousness, Global Neuronal Workspace Integrated Information Theory, while also advancing our understanding supports through information.

Language: Английский

Citations

31
Towards a structural turn in consciousness science DOI Creative Commons
Johannes Kleiner

Consciousness and Cognition, Journal Year: 2024, Volume and Issue: 119, P. 103653 - 103653

Published: Feb. 28, 2024

Recent activities in virtually all fields engaged consciousness studies indicate early signs of a structural turn, where verbal descriptions or simple formalisations conscious experiences are replaced by tools, most notably mathematical spaces. My goal here is to offer three comments that, my opinion, essential avoid misunderstandings these developments on. These concern metaphysical premises approaches, the viability structure-preserving mappings, and question what structure experience first place. I will also explain what, great promises methodologies how they might impact science at large.

Language: Английский

Citations

13
Testing the role of spontaneous activity in visuospatial perception with patterned optogenetics DOI Creative Commons
Kengo Takahashi,

Samuel Pontes Quero,

Julien Fiorilli

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318863 - e0318863

Published: Feb. 27, 2025

A major debate in the field of consciousness pertains to whether neuronal activity or rather causal structure neural circuits underlie generation conscious experience. The former position is held by theoretical accounts based on predictive processing framework (such as neurorepresentationalism and active inference), while latter posited integrated information theory. This protocol describes an experiment, part a larger adversarial collaboration, that was designed address this question through combination behavioral tests mice, functional imaging, patterned optogenetics electrophysiology. experiment will directly test if optogenetic inactivation portion visual cortex not responding behaviorally relevant stimuli affect perception spatial distribution these stimuli, even when neurons being inactivated display no very low spiking activity, so it does induce significant effect other cortical areas. results be compared against predictions, provide contribution towards understanding what substrate is.

Language: Английский

Citations

1
Consciousness or pseudo-consciousness? A clash of two paradigms DOI
Giulio Tononi, Larissa Albantakis,

Leonardo S. Barbosa

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

1
Assessing the commensurability of theories of consciousness: On the usefulness of common denominators in differentiating, integrating and testing hypotheses DOI Creative Commons
Kris Evers, Michele Farisco, Cyriel M. A. Pennartz

et al.

Consciousness and Cognition, Journal Year: 2024, Volume and Issue: 119, P. 103668 - 103668

Published: Feb. 27, 2024

How deep is the current diversity in panoply of theories to define consciousness, and what extent do these share common denominators? Here we first examine different are commensurable (or comparable) along particular dimensions. We posit logical (and, when applicable, empirical) commensurability as a necessary condition for identifying denominators among theories. By consequence, dimensions inclusion set logically empirically consciousness can be proposed. Next, compare limited subset neuroscience-based terms commensurability. This analysis does not yield denominator that might serve minimally unifying model consciousness. Theories seem akin by one remote another. suggest methodology comparing via multiple probing questions, allowing discern overall (dis)similarities between Despite very background definitions conclude that, if attention paid search methological approach brain-consciousness relationships, it should possible principle overcome Babylonian confusion tongues eventually integrate merge

Language: Английский

Citations

7