Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 9, 2023

Pain and itch perception both evoke aversive but qualitatively different feelings. The transmission pathways brain areas that process pain are related, with the anterior cingulate cortex (ACC) being important for affective dimension of sensations. cellular mechanisms by which these two somatosensory stimuli processed in same area, however, remain largely unknown. Here we identified distinct neuronal populations related to processing layer II/III ACC. These include neurons activated separated a short time interval modality-specific only either or regardless between them. Using dual-eGRASP (enhanced green fluorescent protein reconstitution across synaptic partners) technique, found pain- itch-specific preferentially receive connections from mediodorsal thalamic stimuli, respectively. an inhibitory designer receptor exclusively drug (DREADD), although suppressing itch- pain-specific reduced pruriception nociception, respectively, neither type inhibition affected opposite modality. Together, results indicate information ACC involves activity-dependent populations, functionally subsets.

Language: Английский