Consciousness and sleep

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1568 - 1594

Published: May 1, 2024

Language: Английский

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The thalamic reticular nucleus orchestrates social memory

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2368 - 2385.e11

Published: May 2, 2024

Social memory has been developed in humans and other animals to recognize familiar conspecifics is essential for their survival reproduction. Here, we demonstrated that parvalbumin-positive neurons the sensory thalamic reticular nucleus (sTRN

Language: Английский

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Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109919 - 109919

Published: May 7, 2024

Highlights•Optogenetic activation of cortical neurons wakes up mice from NREM and REM sleep•Awakenings are induced more effectively in posterior parietal than prefrontal cortex•Cortical opto stimulation causes EEG behavioral arousal coma•Cortical during deep sevo-dex anesthesiaSummaryThe cerebral cortex is widely considered part the neural substrate consciousness, but direct causal evidence missing. Here, we tested whether optogenetic (PtA) or medial (mPFC) sufficient for three states characterized by progressively deeper unresponsiveness: sleep, a coma-like state muscimol injection midbrain, sevoflurane-dexmedetomidine anesthesia. We find that always awakens both sleep with PtA requiring weaker/shorter light pulses mPFC. Moreover, most cases produce (decrease low frequencies) (recovery righting reflex) brainstem coma, as well These findings provide and/or anesthesia.Graphical abstract

Language: Английский

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Comparison of the connectivity of the posterior intralaminar thalamic nucleus and peripeduncular nucleus in rats and mice

Frontiers in Neural Circuits, Journal Year: 2024, Volume and Issue: 18

Published: April 26, 2024

The posterior intralaminar thalamic nucleus (PIL) and peripeduncular (PP) are two adjoining structures located medioventral to the medial geniculate nucleus. PIL-PP region plays important roles in auditory fear conditioning social, maternal sexual behaviors. Previous studies often lumped PIL PP into single entity, therefore it is not known if they have common and/or different brain-wide connections. In this study, we investigate efferent afferent projections of using reliable anterograde retrograde tracing methods. Both project strongly lateral, anterior basomedial amygdaloid nuclei, posteroventral striatum (putamen external globus pallidus), amygdalostriatal transition area, zona incerta, superior inferior colliculi, ectorhinal cortex. However, rather than send stronger hypothalamic regions such as preoptic area/nucleus, nucleus, ventromedial hypothalamus. As for projections, both receive multimodal information from (inferior colliculus, olivary lateral lemniscus, association cortex), visual (superior colliculus somatosensory (gracile cuneate nuclei), motor (external limbic (central hypothalamus, insular cortex) structures. receives strong related parabigeminal ventral Additional results Cre-dependent viral mice also confirmed main rats. Together, findings study would provide new insights neural circuits functional correlation PP.

Language: Английский

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A distributed auditory network mediated by pontine central gray underlies ultra-fast awakening in response to alerting sounds

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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The lateral thalamus: a bridge between multisensory processing and naturalistic behaviors

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Research Progress of the Inferior Colliculus: From Neuron, Neural Circuit to Auditory Disease

Brain Research, Journal Year: 2024, Volume and Issue: 1828, P. 148775 - 148775

Published: Jan. 20, 2024

Language: Английский

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The Many Unknowns of Partial Sensory Disconnection during Sleep: A Review of the Literature

Clinical and Translational Neuroscience, Journal Year: 2024, Volume and Issue: 8(1), P. 9 - 9

Published: Jan. 24, 2024

When we are asleep, lose the ability to promptly respond external stimuli, and yet spend many hours every day in this inherently risky behavioral state. This simple fact strongly suggests that sleep must serve essential functions rely on brain going offline, a daily basis, for long periods of time. If these did not require partial sensory disconnection, it would be difficult explain why they performed during waking. Paradoxically, despite its central role defining what does, disconnection remains mystery. We have limited understanding how is implemented along pathways; do know whether same mechanisms apply all modalities, nor extent shared between non-rapid eye movement (NREM) REM sleep. The main goal contribution review some knowns unknowns about as first step fill gap.

Language: Английский

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Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(10), P. e1655232024 - e1655232024

Published: Feb. 7, 2024

The inferior colliculus (IC) represents a crucial relay station in the auditory pathway, located midbrain's tectum and primarily projecting to thalamus. Despite identification of distinct cell classes based on various biomarkers IC, their specific contributions organization tectothalamic pathways have remained poorly understood. In this study, we demonstrate that IC neurons expressing parvalbumin (IC

Language: Английский

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Defense or death? A review of the neural mechanisms underlying sensory modality-triggered innate defensive behaviors

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 92, P. 102977 - 102977

Published: Feb. 27, 2025

Language: Английский

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