Mesocorticolimbic circuit mechanisms of social dominance behavior DOI Creative Commons
Tae-Yong Choi, Se‐Jin Jeong, Ja Wook Koo

et al.

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(9), P. 1889 - 1899

Published: Sept. 2, 2024

Abstract Social animals, including rodents, primates, and humans, partake in competition for finite resources, thereby establishing social hierarchies wherein an individual’s standing influences diverse behaviors. Understanding the neurobiological underpinnings of dominance is imperative, given its ramifications health, survival, reproduction. behavior comprises several facets, recognition, decision-making, actions, indicating concerted involvement multiple brain regions orchestrating this behavior. While extensive research has been dedicated to elucidating neurobiology interaction, recent studies have increasingly delved into adverse behaviors such as hierarchy. This review focuses on latest advancements comprehending mechanisms mesocorticolimbic circuit governing dominance, with a specific focus rodent studies, intricate dynamics their implications individual well-being adaptation.

Language: Английский

The role of prospective contingency in the control of behavior and dopamine signals during associative learning DOI Creative Commons
Lechen Qian, Mark Burrell, Jay A. Hennig

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 6, 2024

Associative learning depends on contingency, the degree to which a stimulus predicts an outcome. Despite its importance, neural mechanisms linking contingency behavior remain elusive. Here we examined dopamine activity in ventral striatum - signal implicated associative Pavlovian degradation task mice. We show that both anticipatory licking and responses conditioned decreased when additional rewards were delivered uncued, but remained unchanged if cued. These results conflict with contingency-based accounts using traditional definition of or novel causal model (ANCCR), can be explained by temporal difference (TD) models equipped appropriate inter-trial-interval (ITI) state representation. Recurrent networks trained within TD framework develop representations like our best 'handcrafted' model. Our findings suggest error measure describes dopaminergic activity.

Language: Английский

Citations

8
Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex DOI Creative Commons
Jennifer Isaac, Sonia Karkare, Hymavathy Balasubramanian

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 13, 2024

Language: Английский

Citations

6
Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal DOI Creative Commons
Changyou Jiang, Han Huang, Xiao Yang

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(5)

Published: Jan. 18, 2024

Converging studies demonstrate the dysfunction of dopaminergic neurons following chronic opioid administration. However, therapeutic strategies targeting opioid-responsive ensembles that contribute to development withdrawal remain be elucidated. Here, we used neuronal activity-dependent Tet-Off system label in response initial morphine exposure (Mor-Ens) ventral tegmental area (VTA). Fiber optic photometry recording and transcriptome analysis revealed downregulated spontaneous activity, dysregulated mitochondrial respiratory, ultrastructure, oxidoreductase signal pathways after administration these ensembles. Mitochondrial fragmentation decreased fusion gene mitofusin 1 (Mfn1) were found prolonged withdrawal. Restoration Mfn1 Mor-Ens attenuated excessive oxidative stress Administration Mdivi-1, a fission inhibitor, ameliorated maladaptation plasticity Mor-Ens, accompanied by administration, without affecting analgesic effect morphine. These findings highlighted plastic architecture mitochondria as potential target for analgesic-induced substance use disorders.

Language: Английский

Citations

4
Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories DOI Creative Commons
Alejandro Pan-Vazquez,

Yoel Sanchez Araujo,

Brenna McMannon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Learning a new task is challenging because the world high dimensional, with only subset of features being reward-relevant. What neural mechanisms contribute to initial acquisition, and why do some individuals learn much more quickly than others? To address these questions, we recorded longitudinally from dopamine (DA) axon terminals in mice learning visual task. Across striatum, DA responses tracked idiosyncratic side-specific trajectories. However, even before any rewards were delivered, contralateral-side-specific present dorsomedial striatum (DMS). These pre-existing predicted extent for contralateral stimuli. Moreover, activation improved performance. Thus, conditions projection-specific feature-specific signal help explain individual More broadly, this work implies that functional heterogeneity across projections serves bias target regions towards about different subsets features, providing mechanism dimensionality problem.

Language: Английский

Citations

4
A ventral hippocampal-lateral septum pathway regulates social novelty preference DOI Creative Commons

Maha Rashid,

Sarah Thomas, Jennifer Isaac

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 29, 2024

ABSTRACT The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability recognize kin and engage in appropriate behaviors associated with several types dementia, including Alzheimer’s disease. Mice preferentially spend more time investigating a novel individual relative individual. Yet, how social novelty related information drives increased investigation animal remains poorly understood. Recent evidence has implicated ventral hippocampus (vHPC) as key node encoding about conspecific identity. Of particular interest are vHPC projections lateral septum (LS), region that been driving wide range motivated behaviors. this study using chemogenetics, optogenetics monosynaptic rabies tracing, we identified vHPC-LS-ventral tegmental area (VTA) pathway necessary mice investigate conspecifics. Using established LS neurons make direct connections onto dopaminergic VTA. Thus, have potential via which identity could be transformed drive

Language: Английский

Citations

4
Reward Bases: A simple mechanism for adaptive acquisition of multiple reward types DOI Creative Commons
Beren Millidge, Yuhang Song, Armin Lak

et al.

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(11), P. e1012580 - e1012580

Published: Nov. 19, 2024

Animals can adapt their preferences for different types of reward according to physiological state, such as hunger or thirst. To explain this ability, we employ a simple multi-objective reinforcement learning model that learns multiple values dimensions food water. We show by weighting these learned the current needs, behaviour may be flexibly adapted present preferences. This predicts individual dopamine neurons should encode errors associated with some more than others. provide preliminary test prediction, reanalysed small dataset obtained from single primate in an experiment which our knowledge is only published study where responses stimuli predicting distinct rewards were recorded. observed addition subjective economic value, gradient dimensions; respond most while others fluids. also proposed possible implementation basal ganglia network, and demonstrated how striatal system learn dimensions, even when mixtures prediction error dimensions. Additionally, reproduces instant generalisation new states seen behaviour. Our results demonstrate neural circuit guide animals’ needs.

Language: Английский

Citations

4
Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior DOI Creative Commons

Shannon N. Bennett,

Austin Chang, Forrest D. Rogers

et al.

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 159, P. 105472 - 105472

Published: Dec. 23, 2023

Proper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across lifespan impacts hormone signaling anxiety disorders depression have been associated with dysfunction (both hypo- hyper-active). However, less known about how stress during postnatal development related brain development. Our previous work in mice demonstrated that early-life (ELS) transiently impinged on expression of a transcription factor neurons, Otx2, shown be regulated by hormones. We hypothesized may link experience ELS transcriptional dysregulation within dopaminergic midbrain, ultimately behavior. Here, we find increases thyroid-stimulating levels (inversely signaling) both male female at P21, an effect which recovers adolescence. next tested whether transient treatment synthetic (levothyroxine, LT4) could ameliorate impact sensitivity future stress, genes maintenance, signaling, plasticity ventral tegmental area. Among mice, but not females, juvenile LT4 prevented hypersensitivity adult stress. also found rescuing developmental deficits after restored some altered directly ELS, alterations other sensitive second hit These findings suggest mediates deleterious VTA development, temporary hypothyroidism sufficient prevent hypersensitivity.

Language: Английский

Citations

11
Investigating the effect of Arvcf reveals an essential role on regulating the mesolimbic dopamine signaling-mediated nicotine reward DOI Creative Commons
Yan Wang,

Zhongli Yang,

Xiaoqiang Shi

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 13, 2025

The mesolimbic dopamine system is crucial for drug reinforcement and reward learning, leading to addiction. We previously demonstrated that Arvcf was associated significantly with nicotine alcohol addiction through genome-wide association studies. However, the role mechanisms of in dopamine-mediated processes were largely unknown. In this study, we first showed mediates nicotine-induced behavior by using conditioned place preference (CPP) model on Arvcf-knockout (Arvcf-KO) animal model. Then, revealed mainly expressed VTA dopaminergic neurons whose expression could be upregulated treatment. Subsequently, our SnRNA-seq analysis directly involved biosynthesis neurons. Furthermore, found Arvcf-KO led a significant reduction both synthesis release nucleus accumbens (NAc) stimulation. Specifically, inhibition decreased within VTA-NAc circuit suppressed reward-related behavior, while overexpression opposite results. Taken together, these findings highlight regulating signaling its enhancement as novel mechanism reward. Catenin gene promotes theformation learning enhancing mice.

Language: Английский

Citations

0
Prospective contingency explains behavior and dopamine signals during associative learning DOI
Lechen Qian, Mark Burrell, Jay A. Hennig

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors DOI Creative Commons
Ioannis Koutlas,

Lefkothea Patrikiou,

Stef E. van der Starre

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransmitters (NT). However, function in does not parse along NT-boundaries as, within each NT-class, certain neurons excited by reward and others stressors. Here we identify, male mice, co-activated neuronal ensembles stress, determine their role behaviors. We show that of opposite (opioid vs acute social stress) recruit two distinct ensembles. These continue be preferentially engaged congruent stimuli. Stimulation stress- or aversive/reinforcing, respectively. Strikingly, external fully require activity these small discrete conferring approach/avoidance outcomes. Overall, our study identifies positive negative coding shows indispensability behavior.

Language: Английский

Citations

0