Adolescent drug exposure: A review of evidence for the development of persistent changes in brain function

Brain Research Bulletin, Journal Year: 2020, Volume and Issue: 156, P. 105 - 117

Published: Jan. 8, 2020

Language: Английский

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Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure

Science Advances, Journal Year: 2022, Volume and Issue: 8(18)

Published: May 4, 2022

Adolescent binge drinking is a major risk factor for psychiatric disorders later in life including alcohol use disorder. exposure induces epigenetic reprogramming at the enhancer region of activity-regulated cytoskeleton-associated protein (Arc) immediate-early gene, known as synaptic activity response element (SARE), and decreases Arc expression amygdala both rodents humans. The causal role amygdalar epigenomic regulation SARE adult anxiety after adolescent unknown. Here, we show that dCas9-P300 increases histone acetylation normalizes deficits expression, leading to attenuation excessive rat model exposure. Conversely, dCas9-KRAB repressive methylation SARE, produces control rats. These results demonstrate editing can ameliorate psychopathology

Language: Английский

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Alcohol: Epigenome alteration and inter/transgenerational effect

Alcohol, Journal Year: 2024, Volume and Issue: 117, P. 27 - 41

Published: March 18, 2024

Language: Английский

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Adolescent alcohol exposure changes RNA modifications in adult brain by mass spectrometry-based comprehensive profiling analysis

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(1), P. 108522 - 108522

Published: April 29, 2023

Language: Английский

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Perception of Parental Attitudes and Self-Efficacy in Refusing Alcohol Drinking and Smoking by Spanish Adolescents: A Cross-Sectional Study

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(1), P. 808 - 808

Published: Jan. 1, 2023

Adolescents are particularly vulnerable to initiation of the use substances harmful health, and its increase is cause for concern. The objective this study was analyze relationship between self-efficacy in refusing alcohol attitude adolescents toward drugs their perception parents' refusal. carried out 2019 a sample 1287 students from 11 public high schools province Almería (Spain). Students were aged 14 18 3rd 4th year compulsory secondary education. Drinking Refusal Self-Efficacy Questionnaire-Revised Adolescent version (DRSEQ-RA), Attitudes Toward Taking Drugs-Basic BIP Scale Parents' attitudes Drug Use administered. results showed that family relationships seem have direct impact on adolescent patterns smoking drinking alcohol. However, favorable risk factor tobacco. dimension also acts as protective against probability using or conclusions emphasized communication within core can decrease health.

Language: Английский

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MicroRNA-137 Drives Epigenetic Reprogramming in the Adult Amygdala and Behavioral Changes after Adolescent Alcohol Exposure

eNeuro, Journal Year: 2019, Volume and Issue: 6(6), P. ENEURO.0401 - 19.2019

Published: Nov. 1, 2019

Abstract Adolescent binge drinking is a serious public health concern and risk factor for alcohol use disorder (AUD) comorbid anxiety in adulthood. Chromatin remodeling mediated by epigenetic enzymes including lysine-specific demethylase 1 (LSD1) due to adolescent exposure may play role adult psychopathology. The mechanism which mechanistically regulates reprogramming behavioral changes adulthood unknown. We investigated the of microRNA-137 (miR-137), crucial normal neurodevelopment targets LSD1, intermittent ethanol (AIE) exposure-induced anxiety-like alcohol-drinking behaviors related amygdala rats were exposed 2 g/kg (2 d on/off; AIE) or saline (AIS) during postnatal days (PND)28–PND41 allowed grow analysis behavior, miRNA expression, measures amygdala. Interestingly, miR-137 was increased its target genes Lsd1 + 8a decreased AIE Infusion antagomir directly into central nucleus (CeA) rescues AIE-induced via normalization LSD1 occupancy, Bdnf IV expression H3K9 dimethylation rats. Further, concomitant small interfering RNA (siRNA) infusion CeA prevents miR-137-mediated reversal chromatin at promoter. These novel results highlight as potential therapeutic AUD susceptibility after

Language: Английский

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Contrasting effects of adolescent and early-adult ethanol exposure on prelimbic cortical pyramidal neurons

Drug and Alcohol Dependence, Journal Year: 2020, Volume and Issue: 216, P. 108309 - 108309

Published: Sept. 21, 2020

Language: Английский

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A RELAÇÃO EPIGENÉTICA COM O ÁLCOOL E O NEURODESENVOLVIMENTO

Revista Foco, Journal Year: 2025, Volume and Issue: 18(2), P. e7872 - e7872

Published: Feb. 28, 2025

O neurodesenvolvimento, que envolve partes motora, sensorial, linguagem, comportamental e emocional, é afetado por fatores como estresse, álcool tabaco tanto no período fetal pós-natal, sendo estes efeitos potencialmente duradouros. Como reflexo, há a manifestação de distúrbios comportamentais aprendizado. Nesse contexto, epigenética - modificações herdáveis, não permanentes influenciadas pelo ambiente uma forma explicar os mecanismos com o qual processos acontecem. sentido, este trabalho tem objetivo discutir relação entre exposição ambientais, álcool, contexto do desenvolvimento humano. Métodos: Esta revisão sistemática adotou base dados PubMed, utilizando trabalhos dos últimos 10 anos disponíveis gratuitamente em inglês portugues. Resultados: capaz gerar hipermetilação DNA genes CcnB1, Cdc20, Bub1, Plk1, afetando regulação da divisão celular. Além disso, afeta sobrevivência celular Bcl-xL (Bax), Bcl2, Ccnd2, E2f7, consequente apoptose. Ainda, modula expressão Nr2b, Gria3, gene receptor canabinoide 1, prodinorfina, proopiomelanocortina (POMC), comprometendo diferenciação maturação neuronal. Por fim, influência na plasticidade sináptica migração neuronal através miRNAS miR29b, miR-497, miR-302b, miR-26b. Conclusão: Há um comprometimento global neurodesenvolvimento vias epigenéticas desencadeadas mesmo baixas doses. são necessários mais estudos para esclarecer relacionadas propagação deste fenômeno.

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Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Frontiers in Behavioral Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: March 31, 2020

Adolescence is a developmental period associated with rapid age-specific physiological, neural, and hormonal changes. Behaviorally, human adolescents are characterized by age-typical increases in novelty seeking risk taking, including the frequent initiation of alcohol drug use. Alcohol use typically begins during early adolescence, older often report high levels consumption, commonly referred to as high-intensity drinking. Early-onset heavy drinking adolescence an increased developing disorders later life. Yet, long-term behavioral consequences adolescent that might contribute excessive adulthood still not well understood. Recent animal research, however, using different exposure regimens routes ethanol administration, has made substantial progress identifying last into adulthood. Alterations include anxiety-like behavior, impulsivity, intake, although observed alterations differ function administration. Rodent studies have also shown produces sensitivity ethanol, these reminiscent adolescent-typical responsiveness. The goal this mini-review summarize current state focusing on related exposure, special emphasis changes can foster

Language: Английский

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Histone modifications, DNA methylation, and the epigenetic code of alcohol use disorder

International review of neurobiology, Journal Year: 2020, Volume and Issue: unknown, P. 1 - 62

Published: Oct. 17, 2020

Language: Английский

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