Identification of stress-induced epigenetic methylation onto dopamine D2 gene and neurological and behavioral consequences DOI Creative Commons
Kenneth Blum, Abdalla Bowirrat, David Baron

et al.

Gene & Protein in Disease, Journal Year: 2024, Volume and Issue: 3(1), P. 1966 - 1966

Published: March 29, 2024

The D2 dopamine receptor (DRD2) gene has garnered substantial attention as one of the most extensively studied genes across various neuropsychiatric disorders. Since its initial association with severe alcoholism in 1990, particularly through identification DRD2 Taq A1 allele, numerous international investigations have been conducted to elucidate role different conditions. As February 22, 2024, there are 5485 articles focusing on listed PUBMED. There 120 meta-analyses mixed results. In our opinion, primary cause negative reports regarding polymorphisms is inadequate screening controls, not adequately eliminating many hidden reward deficiency syndrome behaviors. Moreover, pleiotropic effects variants identified neuropsychologic, neurophysiologic, stress response, social defeat, maternal deprivation, and gambling disorder, epigenetic DNA methylation histone post-translational discussed this article. 70 PUBMED for 20 October 19, 2022. For commentary, we did denote and/or methylation; instead, provided a brief summary based behavioral effects. Based fact that Blum Noble characterized allele generalized necessarily specific alcoholism, it now behooves field find ways either use effector moieties edit neuroepigenetic insults or possibly harness idea potentially removing mRNA-reduced expression by inducing “dopamine homeostasis.”

Language: Английский

Consequences of adolescent drug use DOI Creative Commons
Michael Steinfeld, Mary M. Torregrossa

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Oct. 6, 2023

Abstract Substance use in adolescence is a known risk factor for the development of neuropsychiatric and substance disorders adulthood. This part due to fact that critical aspects brain occur during adolescence, which can be altered by drug use. Despite concerted efforts educate youth about potential negative consequences use, initiation remains common amongst adolescents world-wide. Additionally, though there has been substantial research on topic, many questions remain predictors adolescent In following review, we will highlight some most recent literature neurobiological behavioral effects rodents, non-human primates, humans, with specific focus alcohol, cannabis, nicotine, interactions between these substances. Overall, consumption substances produce long-lasting changes across variety structures networks have enduring behavior, emotion, cognition.

Language: Английский

Citations

155
Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges DOI Open Access
Jun Ueda, Taiga Yamazaki,

Hiroshi Funakoshi

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4778 - 4778

Published: March 1, 2023

The advancement in epigenetics research over the past several decades has led to potential application of epigenome-editing technologies for treatment various diseases. In particular, epigenome editing is potentially useful genetic and other related diseases, including rare imprinted as it can regulate expression target region, thereby causative gene, with minimal or no modification genomic DNA. Various efforts are underway successfully apply vivo, such improving specificity, enzymatic activity, drug delivery development reliable therapeutics. this review, we introduce latest findings, summarize current limitations future challenges practical disease therapy, important factors consider, chromatin plasticity, a more effective editing-based therapy.

Language: Английский

Citations

34
CRISPR/Cas9 Landscape: Current State and Future Perspectives DOI Open Access
Marina A. Tyumentseva, Marina A. Tyumentseva, В. Г. Акимкин

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16077 - 16077

Published: Nov. 8, 2023

CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is a unique genome editing tool that can be easily used in wide range of applications, including functional genomics, transcriptomics, epigenetics, biotechnology, plant engineering, livestock breeding, gene therapy, diagnostics, and so on. This review focused on the current CRISPR/Cas9 landscape, e.g., Cas9 variants with improved properties, Cas9-derived fusion proteins, delivery methods, pre-existing immunity against anti-CRISPR their possible roles function improvement. Moreover, this presents detailed outline CRISPR/Cas9-based diagnostics therapeutic approaches. Finally, addresses future expansion editors’ toolbox orthologs other CRISPR/Cas proteins.

Language: Английский

Citations

32
CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model DOI Creative Commons
Lei Wan, Ping Zhong, Pei Li

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 206, P. 106826 - 106826

Published: Feb. 1, 2025

Language: Английский

Citations

1
LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis DOI
Shu Li, Run-Chao He, S Wu

et al.

Circulation Research, Journal Year: 2023, Volume and Issue: 134(1), P. 60 - 80

Published: Dec. 12, 2023

Increasing evidence suggests that long noncoding RNAs play significant roles in vascular biology and disease development. One such RNA,

Language: Английский

Citations

22
Can digital transformation promote the green innovation quality of enterprises? Empirical evidence from China DOI Creative Commons
Yang Huang, Chau-wa Lau

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0296058 - e0296058

Published: March 11, 2024

Digital transformation constitutes a crucial component of the digital economy and represents microcosmic manifestation, playing vital role in advancing enterprise sustainable development from perspective green innovation quality. Using panel data Chinese listed companies 2011 to 2020, study examines impact on quality innovation. The finds that significantly increases enterprises. Moreover, positive effect is strengthened by executive with knowledge experience regions high-level intellectual property protection. findings contribute digitalization research literature innovation, provide suggestions for managers policymakers seeking improve environmental sustainability through developing economies.

Language: Английский

Citations

8
The missing hallmark of health: psychosocial adaptation DOI
Carlos López-Otı́n, Guido Kroemer

Cell Stress, Journal Year: 2024, Volume and Issue: 8, P. 21 - 50

Published: Jan. 1, 2024

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7;184(1):33-63) include features spatial compartmentalization (integrity barriers, containment local perturbations), maintenance homeostasis over time (recycling & turnover, integration circuitries, rhythmic oscillations) and an array adequate responses to stress (homeostatic resilience, hormetic regulation, repair regeneration). These affect all somatic strata the human body (molecules, organelles, cells, supracellular units, organs, organ systems, systemic circuitries meta-organism). Here postulate mental socioeconomic factors must be added this 8×8 matrix as additional hallmark (“psychosocial adaptation”) stratum interactions”), hence building a 9×9 matrix. Potentially, perturbation each affects psychosocial vice versa. Finally, discuss (patho)physiological bases these interactions their implications for improvement.

Language: Английский

Citations

7
Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD DOI Creative Commons
Fulton T. Crews, Victoria A. Macht, Ryan P. Vetreno

et al.

Advances in Drug and Alcohol Research, Journal Year: 2024, Volume and Issue: 4

Published: March 8, 2024

Adolescent alcohol drinking is linked to high rates of adult problems and use disorder (AUD). The Neurobiology Alcohol Drinking in Adulthood (NADIA) consortium adolescent intermittent ethanol (AIE) models binge drinking, followed by abstinent maturation adulthood determine the persistent AIE changes neurobiology behavior. increases preference, anxiety reward seeking, disrupts sleep cognition, all risks for AUD. In addition, induces neuroimmune gene expression neurons glia that alter neurocircuitry HMGB1 a unique signal released from activates multiple proinflammatory receptors, including Toll-like receptors (TLRs), spread induction. increased rat brain post-mortem human AUD brain, where it correlates with lifetime consumption. activation TLR increase expression. Human following show TLRs. Brain regional differences neurotransmitters cell types impact responses Microglia are monocyte-like cells provide trophic synaptic functions, signals sensitize or “prime” during repeated cycles, impacting neurocircuitry. Neurocircuits differently impacted dependent upon neuronal-glial signaling. Acetylcholine an anti-inflammatory neurotransmitter. HMGB1-TLR4 signaling forebrain, reducing cholinergic silencing defining genes through upregulation RE-1 factor (REST), transcription inhibitor known regulate neuronal differentiation. REST induction reduces basal forebrain innervation hippocampus. Adult hippocampal neurogenesis regulated neurogenic niche formed cells. vivo vitro studies find other as well factors, NGF, BDNF, coincident loss synapse marker vChAT. These expression-transcriptomes result reduced neurogenesis. Excitingly, antagonists, anti-inflammatories, epigenetic modifiers like histone deacetylase inhibitors restore findings suggest drugs should be considered therapy may long-lasting reversal psychopathology.

Language: Английский

Citations

5
Gestational 1-nitropyrene exposure causes anxiety-like behavior partially by altering hippocampal epigenetic reprogramming of synaptic plasticity in male adult offspring DOI
Bo Wang, Ting Zhao, Xiaoxi Chen

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 453, P. 131427 - 131427

Published: April 15, 2023

Language: Английский

Citations

13
Impact of Chromatin Organization and Epigenetics on CRISPR-Cas and TALEN Genome Editing DOI
Surbhi Jain, Guanhua Xun, Huimin Zhao

et al.

ACS Synthetic Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

DNA lies at the heart of central dogma life. Altering can modify flow information in fundamental cellular processes such as transcription and translation. The ability to precisely manipulate has led remarkable advances treating incurable human genetic ailments changed landscape biological research. Genome editors CRISPR-Cas nucleases TALENs have become ubiquitous tools basic applied research been translated clinic treat patients. specificity modularity these genome made it possible efficiently engineer genomic DNA; however, underlying principles governing editing outcomes eukaryotes are still being uncovered. Editing efficiency vary from cell type for same target sequence, necessitating de novo design validation efforts. Chromatin structure epigenetic modifications shown affect activity because role they play hierarchical organization DNA. Understanding nuclear search mechanism their molecular interactions with higher order chromatin will lead improved models predicting precise outcomes. Insights studies unlock entire be engineered creation novel therapies critical illnesses.

Language: Английский

Citations

4