Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106200 - 106200
Published: May 1, 2025
Language: Английский
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 160, P. 105643 - 105643
Published: March 24, 2024
Schizophrenia is a highly heterogeneous disorder characterized by multitude of complex and seemingly non-overlapping symptoms. The insular cortex has gained increasing attention in neuroscience psychiatry due to its involvement diverse range fundamental human experiences behaviors. This review article provides an overview the insula's cellular anatomical organization, functional structural connectivity, significance. Focusing on specific insula subregions using knowledge from humans preclinical studies tracings non-human primates, we literature discuss roles each subregion, including somatosensation, interoception, salience processing, emotional social cognition. Building this foundation, then extend these findings reported abnormalities functions individuals with schizophrenia, implicating schizophrenia pathology. underscores vast role experience how abnormal structure function could result wide-ranging symptoms observed schizophrenia.
Language: Английский
Citations
9
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(6)
Published: Feb. 3, 2025
Arousal refers to changes in brain-body state underpinning motivated behavior but lacks a proper definition and taxonomy. Neuroscience psychology textbooks offer surprisingly different views on what arousal is, from global brain-wide modulation of neuronal activity multidimensional construct, with specific patterns tuned given situation. The huge number scientific articles mentioning (~50,000) highlights the importance concept also explains why such vast literature has never been systematically reviewed so far. Here, we leverage tools natural language processing probe nature data-driven, comprehensive manner. We show that comes seven varieties: cognitive, emotional, physiological, sexual, related stress disorders, sleep, or sleep disorders. then ask whether domain-general exists at cortical level, run meta-analyses brain imaging reveal all varieties arousal, except disorders for lack data, converge onto network composed presupplementary motor area left right dorsal anterior insula. More precisely, find dysgranular insular 7 (Jülich atlas), region highest convergence across is specifically associated arousal. might trigger reorganization large-scale networks-a mechanism-resulting context-specific configuration-in line view. Future taxonomies refining alignment between concepts data should include as central component.
Language: Английский
Citations
1
eLife, Journal Year: 2022, Volume and Issue: 11
Published: Sept. 13, 2022
How does binge drinking alcohol change synaptic function, and do these changes maintain consumption? The anterior insular cortex (AIC) dorsolateral striatum (DLS) are brain regions implicated in use disorder. In male, but not female mice, we found that produced glutamatergic adaptations selective to AIC inputs within the DLS. Photoexciting AIC→DLS circuitry male mice during decreased alcohol, water consumption altered mechanics. Further, mechanics alone from session data predicted alcohol-related circuit changes. manipulation did alter operant, valence, or anxiety-related behaviors. These findings suggest alcohol-mediated at govern behavioral sequences may serve as a circuit-based biomarker for development of
Language: Английский
Citations
35
Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14
Published: March 24, 2023
Alcohol Use Disorder (AUD) ranks among the most prevalent mental disorders, extracting ~$250 billion/year in US alone and producing myriad medical social harms. Also, number of deaths related to problem drinking has been increasing dramatically. Compulsive alcohol drinking, characterized by intake that persists despite negative consequences, can be particularly important a major obstacle treatment. With people suffering from AUD during past years, there is critical need understand neurobiology compulsive drives for alcohol, as well development novel pharmacological therapies. Here we discuss rodent compulsion-like (CLAD) models, focusing on two widely used adverse stimuli model responding, quinine adulteration footshook-resistant intake. For both cases, goal uncover behavior patterns brain circuits underlie drive even face consequences. We caveats, benefits, potential mechanisms, models consequence-resistant responding more generally, especially highlight some advantages quinine-resistance over footshook-resistance. Further, since this review contributes Special issue focused Molecular Aspects Drug Use, our new findings showing how noradrenergic system CLAD responding. In particular, comment importance α1 β adrenergic receptors (ARs) targets treating AUD.
Language: Английский
Citations
20
NeuroImage Clinical, Journal Year: 2024, Volume and Issue: 43, P. 103625 - 103625
Published: Jan. 1, 2024
Functional neurological disorder (FND) is a common neuropsychiatric condition with established diagnostic criteria and effective treatments but for which the underlying neuropathophysiological mechanisms remain incompletely understood. Recent neuroimaging studies have revealed FND as multi-network brain disorder, unveiling alterations across limbic, self-agency, attentional/salience, sensorimotor networks. However, relationship between identified disease progression or improvement less explored.
Language: Английский
Citations
7
Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(2), P. 790 - 800
Published: Oct. 7, 2022
The diverse functional roles of the insula may emerge from its heavy connectivity to an extensive network cortical and subcortical areas. Despite several previous attempts investigate hierarchical organization by applying recently developed gradient approach insula-to-whole brain data, little is known about whether how there variability across gradients different cerebral systems. Resting-state MRI data 793 healthy subjects were used discover validate insula, which computed based on voxel-wise profiles distinct We identified three primary patterns higher-order transmodal associative systems, including prefrontal, posterior parietal, temporal cortices, limbic lobule, showed a ventroanterior-dorsal axis insula; those lower-order unimodal motor, somatosensory, occipital displayed radiating transitions dorsoanterior toward both ventroanterior dorsoposterior parts nuclei exhibited along anterior-posterior insula. Apart complementing extending literature heterogeneous subregions, presented framework offer ample opportunities refine our understanding role in many disorders.
Language: Английский
Citations
25
Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 28, 2023
Compulsive alcohol drinking is a key symptom of use disorder (AUD) that particularly resistant to treatment. An understanding the biological factors underly compulsive will allow for development new therapeutic targets AUD. One animal model involves addition bitter-tasting quinine an ethanol solution and measuring willingness consume despite aversive taste. Previous studies have demonstrated this type aversion-resistant modulated in insular cortex male mice by specialized condensed extracellular matrix known as perineuronal nets (PNNs), which form lattice-like structure around parvalbumin-expressing neurons cortex. Several laboratories shown female exhibit higher levels intake, but role PNNs females behavior has not been examined. Here we compared insula determined if disrupting would alter intake. were visualized fluorescent labeling with Wisteria floribunda agglutinin (WFA) disrupted microinjecting chondroitinase ABC, enzyme digests chondroitin sulfate glycosaminoglycan component PNNs. Mice tested consumption sequentially increasing concentrations two-bottle choice dark procedure. PNN staining intensity was mice, suggesting might contribute elevated drinking. However, disruption had limited effect on females. In addition, activation during drinking, measured c-fos immunohistochemistry, lower than males. Taken together, these results suggest neural mechanisms underlying differ males
Language: Английский
Citations
16
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 9083 - 9083
Published: May 22, 2023
Human neuroimaging has demonstrated the existence of large-scale functional networks in cerebral cortex consisting topographically distant brain regions with functionally correlated activity. The salience network (SN), which is involved detecting salient stimuli and mediating inter-network communication, a crucial that disrupted addiction. Individuals addiction display dysfunctional structural connectivity SN. Furthermore, while there growing body evidence regarding SN, addiction, relationship between two, are still many unknowns, fundamental limitations to human studies. At same time, advances molecular systems neuroscience techniques allow researchers manipulate neural circuits nonhuman animals increasing precision. Here, we describe attempts translate uncover circuit-level mechanisms. To do this, review connections its homology across species. We then existing literature circuit-specific perturbation SN sheds light on how cortical operate, both within outside context Finally, highlight key outstanding opportunities for mechanistic studies
Language: Английский
Citations
16
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 133, P. 111008 - 111008
Published: April 18, 2024
Language: Английский
Citations
6
Mindfulness, Journal Year: 2022, Volume and Issue: 13(8), P. 1857 - 1875
Published: June 21, 2022
Language: Английский
Citations
22