Association of schizophrenia, major depression, and bipolar disorder with sarcopenia-related traits: a bidirectional two-sample Mendelian randomization study DOI Creative Commons
Dong Zhu, Qifan Yang, Xinyu Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 21, 2023

Abstract The rising incidence of schizophrenia, depression, bipolar disorder, and other mental illnesses have an association with sarcopenia (SP). Observational studies are susceptible to confounding factors. Mendelian randomization (MR) offer a way mitigate the influence such factors when assessing causality. causal connection between SP was evaluated using inverse-variance weighted (IVW) MR methods. Sensitivity analyses were also performed. We found schizophrenia exhibited negative increased whole-body FFM (fat free mass) (odds ratio [OR] = 0.987, 95% CI: 0.979–0.996, P 0.03), that attributed reduction in both lower legs (OR 0.990, 0.981–0.999, 0.037; OR 0.984, 0.975–0.993, 0.000). Schizophrenia negatively correlated upper limb, 0.979–0.994, 0.001, 0.986, 0.997–0.996, 0.004. Major depression walking pace related 0.965, 0.935–0.996, 0.027). Bipolar disorder associated decreased left leg 0.979, 0.960–0.999, 0.036). Both limbs showed FFM, right having 0.973, 0.953–0.993, 0.008 0.951–0.994, 0.014, respectively. Additionally, 1.021, 1.005–1.038, 0.012).A potential relationship existed among SP-related traits, major addition disorder. In conclusion, significant relationships exist SP. worsens increasing severity illness. demonstrated apart from

Language: Английский

Sex differences in the inflammation-depression link: A systematic review and meta-analysis DOI Creative Commons

Dana A. Jarkas,

Ally H. Villeneuve,

Ayeila Z.B. Daneshmend

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 121, P. 257 - 268

Published: July 30, 2024

Major Depressive Disorder (MDD) is a heterogeneous disorder that affects twice as many women than men. Precluding advances in more tailored and efficacious treatments for depression the lack of reliable biomarkers. While linked to elevations inflammatory immune system functioning, this relationship not evident among all individuals with may vary based on symptom subtypes and/or sex. This systematic review meta-analysis examined whether peripheral markers are sex-specific. PRISMA guidelines were followed review, comprehensive search strategy identified studies from PubMed PsycInfo was applied. Studies included if they reported C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α IL-1β males females depressed healthy adults. We 23 satisfied these inclusion criteria. Random-effects models fit, measures association summarized between levels circulating inflammation females. Sex-based analyses revealed elevated CRP (Cohen's d = 0.19) relative their counterparts (p 0.02), an effect apparent -0.01). Similarly, IL-6 increased compared controls 0.51; p 0.04), but once again found 0.16). TNF-α 0.01), no statistically significant sex differences found. The resulted only three articles, thus, results presented supplemental section. our understanding unique involvement biomarkers men women, which help inform sex-specific treatment approaches future.

Language: Английский

Citations

12
Depressive symptoms and all-cause mortality among middle-aged and older people in China and associations with chronic diseases DOI Creative Commons

Lan Zhu,

Yixi Wang, Jiaqi Li

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 22, 2024

Introduction It remains unclear whether depressive symptoms are associated with increased all-cause mortality and to what extent chronic disease mortality. The study aims explore the relationship between mortality, how may, in turn, affect among Chinese middle-aged older people through diseases. Methods Data were collected from China Health Retirement Longitudinal Study (CHARLS). This cohort involved 13,855 individuals Wave 1 (2011) 6 (2020) of CHARLS, which is a nationally representative survey that collects information residents ages 45 intrinsic mechanisms Center for Epidemiological Studies Depression Scale (CES-D-10) was validated CHARLS. Covariates included socioeconomic variables, living habits, self-reported history Kaplan–Meier curves depicted rates by symptom levels, Cox proportional hazards regression models estimating hazard ratios (HRs) Results Out total participants included, median ( Q 1, 3) age 58.00 (51.00, 63.00) years. Adjusted all covariates, adults had higher rate (HR = 1.20 [95% CI, 1.09–1.33]). An observed 55–64 years old 1.23 1.03–1.47]) more than 65 1.32 1.18–1.49]), agricultural Hukou 1.44, 1.30–1.59]), nonagricultural workload 1.81 1.61–2.03]). Depressive risks patients hypertension 1.19 1.00–1.40]), diabetes 1.41[95% 1.02–1.95]), arthritis 1.29 1.09–1.51]). Conclusion raise risk, particularly those aged 55 above, rural household registration (agricultural Hukou), workers, hypertension, diabetes, arthritis. Our findings longitudinal data this offer valuable insights interventions targeting depression, such as early detection, integrated care management, healthy lifestyles; community support may help reduce people.

Language: Английский

Citations

9
Relationship between human oral microbiome dysbiosis and neuropsychiatric diseases: An updated overview DOI

Kai Tao,

Yanling Yuan,

Qinglian Xie

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 471, P. 115111 - 115111

Published: June 12, 2024

Language: Английский

Citations

8
Immuno-metabolic depression: from concept to implementation DOI Creative Commons
Brenda W.J.H. Penninx, Femke Lamers, Rick Jansen

et al.

The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 48, P. 101166 - 101166

Published: Dec. 18, 2024

Language: Английский

Citations

8
Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review DOI Open Access
Ani Zerekidze, Meng Li, Alexander Refisch

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 593 - 593

Published: Jan. 19, 2024

Background: Suicide remains a persistent global health challenge, resisting widespread prevention efforts. According to previous findings, toxoplasmosis is particularly associated with altered decision making, which could lead risk-taking behavior, thereby increasing the likelihood for suicidal behavior (SB). In addition, discussion about role of microbiome in psychiatric disorders has emerged lately, also makes it relevant investigate its context SB. Therefore, two systematic reviews are integrated this paper, and existing knowledge comprehensively summarized regarding association between microbial pathogens Methods: We conducted search keywords including SB Toxoplasma gondii (Suicid* AND Toxoplasm*) Microbiome Microbiota) throughout PubMed Scopus retrieve related studies up 9 November 2023, identifying 24 eligible records. The subjects included had have fulfilled criteria an disorder as defined by DSM-5, death cases needed been suicide. Results: Most reported significant SB, suggesting higher infected population. Regarding microbiome, only very few investigated alterations microbiome. Based on six studies, there were some indications link changes Conclusion: cognitive aspects making T. gondii-infected individuals should be further unravel underlying mechanisms. Further sufficiently powered establish

Language: Английский

Citations

4
Exploring the Potential of Probiotics and Prebiotics in Major Depression: From Molecular Function to Clinical Therapy DOI
Xin Yuan,

Jianbo Chai,

Wenqiang Xu

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: 16(6), P. 2181 - 2217

Published: July 30, 2024

Language: Английский

Citations

4
Das gastrointestinale Mikrobiom – Vision und Mission DOI
Andreas Stallmach

DMW - Deutsche Medizinische Wochenschrift, Journal Year: 2025, Volume and Issue: 150(04), P. 157 - 162

Published: Jan. 29, 2025

The gastrointestinal microbiome influences physiological functions and is altered in a variety of diseases. causality "dysbiosis" the pathogenesis not always proven; association studies are often involved. Patients with IBD, bacteria, fungi, bacteriophages, archaea show disease-typical patterns associated metabolome disturbances. Fecal transfer (FMT) for treating various diseases subject numerous clinical studies. Currently, recurrent Clostridioides difficile infection (rCDI) only confirmed indication recommended medical guidelines. In Germany, FMT to Medicines Act may be carried out as part individual healing attempts or For patient safety, repeated donor screening, ideally construction chair bench, necessary. This significantly limits nationwide availability Germany. Microbiota-based therapeutics prepared from stool tested donors have recently been approved by US Food Drug Administration (FDA) prevention rCDI. More microbiome-based medicines can expected future.

Language: Английский

Citations

0
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review DOI Creative Commons
Leilei Zhang, Pascual García-Pérez, Barbara Muñoz-Palazón

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172915 - 172915

Published: May 6, 2024

The increasing trend regarding the use of plastics has arisen an exponential concern on fate their derived products to environment. Among these derivatives, microplastics and nanoplastics (MNPs) have been featured for associated environmental impact due low molecular size high surface area, which prompted ubiquitous transference among all interfaces. Due heterogenous chemical composition MNPs, study particles focused a number studies, as result myriad physicochemical properties that contribute co-transference wide range contaminants, thus becoming major challenge scientific community. In this sense, both primary secondary MNPs are well-known be adscribed industrial urbanized areas, from they massively released environment through multiscale level, involving atmosphere, hydrosphere, lithosphere. Consequently, much research conducted understanding interconnection between those interfaces, motivate spread contaminants biological systems, being mostly represented by biosphere, especially phytosphere and, finally, anthroposphere. These findings highlighted potential hazardous risk human health different mechanisms environment, requiring deeper approach define real exposure. As result, there is gap knowledge high-throughput perspective. review, metabolomics-based overview interfaces was proposed, considering technology highly valuable tool decipher opening novel perspective contaminants.

Language: Английский

Citations

3
SorCS2 is involved in promoting periodontitis‐induced depression‐like behaviour in mice DOI
Yingxue Li, Yao Yang, Xiaoyue Guan

et al.

Oral Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Abstract Background Emerging evidence supports the association between periodontitis and depression, although mechanisms are unclear. This study investigated role of SorCS2 in pathogenesis periodontitis‐induced depression. Materials Methods An experimental model was established using knockout mice their wild‐type littermates, depression‐like behaviour evaluated. The expression proBDNF signalling, neuronal activity, glutamate‐associated signalling pathways were further measured by western blotting immunofluorescence. In addition, neuroinflammatory status, astrocytic microglial markers, corticosterone‐related factors immunofluorescence, blotting, enzyme‐linked immunosorbent assays. Results deficiency alleviated mice. Further results suggested that downregulated pro‐BDNF glutamate restored activities with periodontitis. Neuroinflammation mouse hippocampus triggered but not affected deficiency. levels corticosterone glucocorticoid receptors also altered. Conclusion Our study, for first time, reveals critical underlying mechanism involves hippocampus, providing a novel therapeutic target periodontitis‐associated

Language: Английский

Citations

2
Gut microbiome in atypical depression DOI Creative Commons
Anne Busch, Sagnik Roy, Dario-Lucas Helbing

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 349, P. 277 - 285

Published: Jan. 9, 2024

Recent studies showed that immunometabolic dysregulation is related to unipolar major depressive disorder (MDD) and it more consistently maps MDD patients endorsing an atypical symptom profile, characterized by energy-related symptoms including increased appetite, weight gain, hypersomnia. Despite the documented influence of microbiome on immune regulation energy homeostasis, have not yet investigated differences among clinical groups in individuals with MDD. Fifteen features according Diagnostic Statistical Manual Mental Disorders (DSM-5)-5, forty-four fulfilling DSM-5 criteria for subtype, nineteen healthy controls were included study. Participants completed detailed assessment stool samples collected. Samples sequenced prokaryotic 16S rRNA gene, V3-V4 variable regions. Only no antibiotic exposure previous 12 months a minimum >2000 quality-filtered reads analyses. There statistically significant alpha- beta-diversity between controls. However, within group, there was increase Verrucomicrobiota phylum, Akkermansia as predominant bacterial genus. Cross-sectional data, modest sample size, significantly body mass index group. overall groups. found at several taxonomic levels. Studies larger longitudinal relevant confounders are needed advance understanding microbial influences heterogeneity depression.

Language: Английский

Citations

2