Mediating role of gut microbiota on Baduanjin for cognitive function in community-dwelling older adults with mild cognitive impairment: a study protocol for a cluster randomised controlled trial DOI Creative Commons
L. Sun, Geng Qian,

Guohua Zheng

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e087684 - e087684

Published: Nov. 1, 2024

Introduction The gut microbiome plays an important role in maintaining both cognitive and physical functions older adults, dysbiosis is pathophysiological mechanism of mild impairment (MCI) adults. As a typical traditional Chinese mind-body exercise, regular Baduanjin training has been shown to improve function modulate the community-dwelling However, potential benefits on remains unclear. aim this study investigate mediating effect between improvement adults with MCI. Methods analysis This two-arm, randomised, parallel-controlled, single-blinded trial. Four residential communities (clusters) total 64 eligible participants (16 each community) will be randomised 1:1 either 24-week exercise intervention group (60 min per session, four sessions week) or no specific control group. Global subdimensions cognition including executive function, visuospatial language memory assessed using Montreal Cognitive Assessment Scale, Trail Making Test, Auditory Verbal Learning Boston Naming Test-30 Clock-Drawing while its metabolomics detected 16S rRNA ultra-high-performance liquid chromatography–tandem mass spectrometry at baseline end intervention. microbiota analysed linear mixed models bootstrapping method Hayes process. Ethics dissemination conforms Declaration Helsinki principles relevant ethical guidelines. Ethical approval obtained from Committee Shanghai University Medicine Health Sciences (approval number: 2023-GZR-011). Written informed consent all participants. Results disseminated groups peer-reviewed journal(s), international national scientific conferences. Key findings also shared social media, healthcare providers, support access for non-research audiences. Trial registration number ChiCTR2300078147.

Language: Английский

Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature DOI Open Access
Ana Isabel Beltrán-Velasco, Manuel Reiriz, Sara Uceda

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 3010 - 3010

Published: March 5, 2024

This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in symptomatological intervention neurodegenerative disease. The existence gut microbiota dysbiosis has been associated with systemic inflammatory processes present disease, creating opportunity for new treatment strategies. involves modifying strains that constitute to enhance synaptic function through gut–brain axis. Recent studies have evaluated beneficial effects on motor and cognitive symptomatology, alone or combination. includes 20 research articles (n = 3 human n 17 animal models). main result this was combination produced improvements symptomatology related However, one included reported negative after administration plantarum. provides current relevant information about probiotic pathologies such as Alzheimer’s Parkinson’s disease Multiple Sclerosis.

Language: Английский

Citations

17
Probiotics: health benefits, microencapsulation, and viability, combination with natural compounds, and applications in foods DOI
Marcieli Peruzzolo, Giovana Cristina Ceni, Alexander Junges

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106253 - 106253

Published: Feb. 1, 2025

Language: Английский

Citations

2
Neurobiology, Molecular Pathways, and Environmental Influences in Antisocial Traits and Personality Disorders. DOI Creative Commons
Przemysław Adamczyk, Andrew Shaw, Ilaria Morella

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110322 - 110322

Published: Jan. 1, 2025

Personality disorders (PDs) are psychiatric conditions characterized by enduring patterns of cognition, emotion, and behaviour that deviate significantly from cultural norms, causing distress or impairment. The aetiology PDs is complex, involving both genetic environmental factors. Genetic studies estimate the heritability at 30% to 60%, implicating genes involved in neurotransmitter regulation, such as those for serotonin transporters dopamine receptors. Environmental factors, including childhood trauma chronic stress, interact with predispositions induce epigenetic modifications like DNA methylation histone modifications, contributing PD development. Neurobiological research has identified structural functional abnormalities brain regions related emotional regulation social amygdala, prefrontal cortex, limbic system. These linked impaired emotion processing interpersonal functioning PDs. This review focuses on how factors shape maladaptive behaviours endophenotypes central many It explores interaction between Ras-ERK, p38, mTOR molecular pathways response stimuli, examines role oxidative stress mitochondrial metabolism these processes. Also reviewed various types existing animal models replicate key endophenotypes, highlighting changes neurotransmitters neurohormones. Identifying biomarkers can lead development "enviromimetic" drugs, which mimic influences activate pathways, facilitating targeted, personalized treatments based profiles individuals Ultimately, understanding mechanisms promises enhance diagnostic accuracy, prognosis, therapeutic outcomes affected individuals.

Language: Английский

Citations

1
Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being DOI Creative Commons

Ashish Kumar Meher,

Biswajeet Acharya, Prafulla Kumar Sahu

et al.

Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 126 - 147

Published: March 1, 2024

Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.

Language: Английский

Citations

7
Efficacy of probiotic supplements on Parkinson's disease: A systematic review and meta-analysis DOI Creative Commons

Xiaxia Jin,

Wendi Dong,

Kaile Chang

et al.

Complementary Therapies in Medicine, Journal Year: 2024, Volume and Issue: 82, P. 103045 - 103045

Published: May 4, 2024

This study aimed to evaluate the clinical efficacy and safety of probiotics supplementation in treatment Parkinson's disease (PD). We searched China National Knowledge Infrastructure (CNKI), Weipu (VIP) database, Wanfang Database, Sinomed (CBM), PubMed, Embase, Cochrane library Web Science databases for eligible studies from inception January 4th, 2024. Randomized controlled trials (RCTS) comparing effects probiotic supplements placebo patients with PD. Meta-analysis was conducted software Review Manager 5.4. The quality assessment performed according risk bias tool. A total 11 RCTs 756 PD were included this study. found that could increase number complete bowel movements (CBMs) per week improved scores Patient Assessment Constipation Quality Life Questionnaire (PAC-QOL) (SMD = 0.73, 95% CI: 0.54 - 0.92, P < 0.00001, I2 45%; SMD -0.79, -1.19 -0.39, 0.001, 55%, respectively) compared group. However, there no significant difference between two groups improving fecal traits defecation efforts 0.87, 0.01 1.74, 0.05, 94%; 1.24, -1.58 4.06, > 98%, respectively). In terms composite scale scores: after treatment, Movement Disorder Society-Unified-Parkinson Disease Rating Scale Ⅲ score (MDS-UPDRSⅢ) group -0.09, -0.35 0.16, 0%). conclusion, based on overall results available studies, our suggested potential value constipation symptoms patients. Therefore, may be one adjuvant therapy PD-related findings provide more proof supporting effectiveness probiotics, encouraging utilized alone or combination other therapies practice well-designed large sample sizes are required.

Language: Английский

Citations

5
Irisin's emerging role in Parkinson's disease research: A review from molecular mechanisms to therapeutic prospects DOI Creative Commons

Ruqing Qiu,

Weilu Sun,

Yana Su

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123088 - 123088

Published: Sept. 30, 2024

Language: Английский

Citations

4
The impact of probiotic supplementation on gastric motility and nutrient absorption in elderly patients with Gastrointestinal disorders DOI Creative Commons
Ping Gong, Xiaobing Tang

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 20, 2025

Gastrointestinal disorders (GIDs) in the elderly often lead to impaired gastric motility and nutrient absorption, exacerbating malnutrition. Probiotics, particularly Lactobacillus rhamnosus GG (LGG), may enhance absorption. This study evaluates impact of LGG supplementation on absorption patients with GIDs. A retrospective analysis was conducted 231 GIDs, divided into a probiotic (PS) group (n = 110) NPS 121). The PS received (1 × 1010 CFU, twice daily) for at least 7 days. Baseline post-treatment measurements included via ultrasonography, gastrointestinal hormone levels using radioimmunoassay, markers through ELISA calorimetry. Post-treatment, exhibited significantly improved motility, increased antral contraction amplitude (58.65 mm vs. 56.53 mm; P 0.004), frequency (4.06 3.81 times/min; 0.009), reduced half-emptying time (28.15 min 29.77 min; 0.007). Hormone analyses showed elevated motilin neuropeptide Y decreased vasoactive intestinal peptide (P < 0.05). Nutrient indicated stool fat, protein, carbohydrate content, enhanced permeability, weight digestibility energy, protein enhances indicating potential therapeutic benefits addressing digestive dysfunction malnutrition this demographic.

Language: Английский

Citations

0
Probiotic Products from Laboratory to Commercialization DOI
Lei Guo, Aman Khan, Grażyna Budryn

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104807 - 104807

Published: Nov. 1, 2024

Language: Английский

Citations

3
Gut Microbiota and Exercise: Probiotics to Modify the Composition and Roles of the Gut Microbiota in the Context of 3P Medicine DOI Creative Commons
Yongfu Liu, Yuting Hu, Bin Ma

et al.

Microbial Ecology, Journal Year: 2025, Volume and Issue: 88(1)

Published: May 3, 2025

Prolonged and intense physical activity can trigger stress response mechanisms across various physiological systems-including the cardiovascular, respiratory, gastrointestinal, musculoskeletal, neuroendocrine systems-disrupting energy metabolism, immune function, redox balance, hormonal regulation. Critically, when not accompanied by adequate recovery, such exertion may impair rather than enhance athletic performance. In parallel, there has been growing interest in probiotics as natural, safe, accessible dietary supplements with potential to support performance recovery. Emerging evidence highlights pivotal role of gut microbiome mediating communication along gut-brain gut-muscle axes, thereby influencing only metabolic functions but also neuromuscular adaptation fatigue resistance. This review explores through which exercise performance, mitigate exercise-induced fatigue, improve via modulation inflammation, oxidative stress, signaling pathways. Framed within context predictive, preventive, personalized medicine (3P medicine), this paper emphasizes diagnostic therapeutic probiotic strategies optimizing qualitative quantitative assessment microbiota host responses.

Language: Английский

Citations

0
<em>Bifidobacterium infantis</em> and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease. A Systematic Review. DOI Open Access
Manuel Reiriz, Ana Isabel Beltrán-Velasco, Víctor Echeverry‐Alzate

et al.

Published: May 31, 2024

: This Systematic Review focused on the use of Bifidobacterium infantis and breve in neurodegenerative diseases. The study metabolomics has demonstrated relationship between dysbiosis neuronal death. modulation gut microbiota intervention these pathologies become a promising area study, showing beneficial results such as improvement synaptic function, reduction neuroinflammation, well associated neuropsychiatric symptoms. Several studies have addressed administration breve, alone, conjunction or combination with other strains, includes 17 research articles (n=5 humans n=12 animal models) main result was that produced improvements disease-related symptomatology degenerative cellular processes. However, some shown neutral certain variables. These data suggest probiotics neuroprotective effect may delay progression disease. provides relevant updated information strains Alzheimer&#039;s disease Parkinson&#039;s

Language: Английский

Citations

1