Brain responses in aggression-prone individuals: A systematic review and meta-analysis of functional magnetic resonance imaging (fMRI) studies of anger- and aggression-eliciting tasks

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2022, Volume and Issue: 119, P. 110596 - 110596

Published: July 6, 2022

Reactive aggression in response to perceived threat or provocation is part of humans' adaptive behavioral repertoire. However, high levels can lead the violation social and legal norms. Understanding brain function individuals with as they process anger- aggression-eliciting stimuli critical for refining explanatory models thereby improving interventions. Three neurobiological reactive - limbic hyperactivity, prefrontal hypoactivity, dysregulated limbic-prefrontal connectivity have been proposed. these are based on neuroimaging studies involving mainly non-aggressive individuals, leaving it unclear which model best describes those a history aggression. We conducted systematic literature search (PubMed Psycinfo) Multilevel Kernel Density meta-analysis (MKDA) nine functional magnetic resonance imaging (fMRI) (eight included between-group analysis [i.e., vs. control groups], five within-group analysis). Studies examined responses tasks putatively eliciting anger alone relative controls. Individuals exhibited greater activity superior temporal gyrus regions comprising cognitive default mode networks (right posterior cingulate cortex, precentral gyrus, precuneus, right inferior frontal gyrus) during baseline conditions. Compared controls, increased (left hippocampus, left amygdala, parahippocampal (superior, middle, gyrus), reduced occipital calcarine cortex). These findings lend support hyperactivity aggression, further indicate altered conditions face speech processing.

Language: Английский

---

Resting-state functional connectivity patterns associated with childhood maltreatment in a large bicentric cohort of adults with and without major depression

Psychological Medicine, Journal Year: 2022, Volume and Issue: 53(10), P. 4720 - 4731

Published: June 27, 2022

Childhood maltreatment (CM) represents a potent risk factor for major depressive disorder (MDD), including poorer treatment response. Altered resting-state connectivity in the fronto-limbic system has been reported maltreated individuals. However, previous results smaller samples differ largely regarding localization and direction of effects.We included healthy depressed [n = 624 participants with MDD; n 701 control (HC) participants] that underwent functional MRI measurements provided retrospective self-reports using Trauma Questionnaire. A-priori defined regions interest [ROI; amygdala, hippocampus, anterior cingulate cortex (ACC)] were used to calculate seed-to-voxel connectivities.No significant associations between any ROI found across MDD HC no interaction effect diagnosis became significant. Investigating patients only yielded maltreatment-associated increased amygdala dorsolateral frontal areas [pFDR < 0.001; η2partial 0.050; 95%-CI (0.023-0.085)]. This was robust various sensitivity analyses associated concurrent symptom severity. Particularly strong amygdala-frontal observed acutely individuals 264; pFDR 0.091; (0.038-0.166)). Weaker evidence - not surviving correction multiple altered supracallosal ACC maltreatment.The majority correlates CM could be replicated this large-scale study. The strongest clinically relevant adult amygdala-dorsolateral depression. Future studies should explore relevance pathway subgroup patients.

Language: Английский

---

Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(11), P. 4602 - 4612

Published: April 19, 2023

Language: Английский

---

Transcutaneous Auricular Vagus Nerve Stimulation to Improve Emotional State

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 407 - 407

Published: Feb. 9, 2024

Emotional experiences are a part of our lives. The maladaptive functioning an individual's emotional field can lead to disturbances various kinds, such as anxiety and depression. Currently, there is increasing prevalence disorders that cause great human suffering high socioeconomic costs. processing has biological basis. major neuroscientific theories emotion based on functioning, all them take into account the anatomy function tenth cranial nerve: vagus nerve. nerve connects subdiaphragmatic supradiaphragmatic areas modulates basis interoceptive functioning. Auricular stimulation new innovative neuromodulation technique Several interventions have shown this neurostimulation very promising resource for treating disorders. In paper, we summarise three emotion, explain what transcutaneous auricular is, present arguments its use continued research.

Language: Английский

---

Major depressive disorder associated alterations in the effective connectivity of the face processing network: a systematic review

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 25, 2024

Major depressive disorder (MDD) is marked by altered processing of emotional stimuli, including facial expressions. Recent neuroimaging research has attempted to investigate how these stimuli alter the directional interactions between brain regions in those with MDD; however, methodological heterogeneity made identifying consistent effects difficult. To address this, we systematically examined studies investigating MDD-associated differences present effective connectivity during We searched five databases: PsycINFO, EMBASE, PubMed, Scopus, and Web Science, using a preregistered protocol (registration number: CRD42021271586). Of 510 unique screened, 17 met our inclusion criteria. These identified that compared healthy controls, participants MDD demonstrated (1) reduced from dorsolateral prefrontal cortex amygdala negatively valenced expressions, (2) increased inhibitory ventromedial happy Most anterior cingulate noted their connectivity; precise nature was inconsistent studies. As such, commonalities observed across modalities warrant careful investigation determine specificity particular subregions Future examining longitudinal changes associated treatment response may provide important insights into mechanisms underpinning therapeutic interventions, thus enabling more targeted strategies.

Language: Английский

---

Brain oscillations during emotion regulation and the two-dimensional model of adult attachment

Biological Psychology, Journal Year: 2024, Volume and Issue: 189, P. 108793 - 108793

Published: April 16, 2024

Emotion Regulation (ER) refers to the processes by which individuals influence their own emotions. It is a crucial aspect of human behavior, affecting everything from interpersonal relationships mental health. The relationship between ER and Attachment Theory (AT) pivotal. AT suggests that early bonds with primary caregivers future expectations behaviors. These initial experiences shape internal models self others, how regulate Understanding interplay essential for comprehending affective system. In this study, we explored neural underpinnings ER, focusing on two distinct strategies: cognitive reappraisal expressive suppression. Using electroencephalography (EEG), examined changes in oscillations 52 adults during an task. Specifically, observed increased frontal theta activity (3-6 Hz) compared suppression strategies. This enhanced control engagement. Conversely, suppression, noted decrease beta frequency (15-30 central electrodes, indicative differing processes. Further integrating psychological theories, these markers dimensions attachment. Employing Experiences Close Relationships-12 scale (ECR-12), identified negative correlation attachment anxiety activity. Lower levels were associated activity, reflecting potentially more effective emotion regulation. Additionally, found higher corresponded fewer difficulties emotional measured Difficulties Scale (DERS). Regarding our findings revealed interesting Emotional Inattention, concept tied Avoidance. may serve as marker specific attachment-related processing. results highlight pathways involved different strategies responses

Language: Английский

---

Frontal theta oscillations during emotion regulation in people with borderline personality disorder

BJPsych Open, Journal Year: 2024, Volume and Issue: 10(2)

Published: March 1, 2024

Background Borderline personality disorder (BPD) is a severe psychiatric conceptualised as of emotion regulation. Emotion regulation has been linked to frontolimbic network comprising the dorsolateral prefrontal cortex and amygdala, which apparently synchronises its activity via oscillatory coupling in theta frequency range. Aims To analyse whether there are distinct differences frontal brain regions between individuals with BPD matched controls during by cognitive reappraisal. Method Electroencephalogram (EEG) recordings were performed 25 women diagnosed reappraisal task participants instructed downregulate negative emotions evoked aversive visual stimuli. Between- within-group time–frequency analyses conducted regulation-associated (3.5–8.5 Hz). Results Oscillatory differed Regulation-associated increases lower cohort compared controls. Functional connectivity analysis for changes band revealed multivariate interaction measure (MIM) increase persons Conclusions Our findings support notion alterations BPD, may be underlying core symptoms such deficits The results add growing body evidence altered dynamics populations, might investigated individualised treatment targets using non-invasive stimulation methods.

Language: Английский

---

MES-CTNet: A Novel Capsule Transformer Network Base on a Multi-Domain Feature Map for Electroencephalogram-Based Emotion Recognition

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 344 - 344

Published: March 30, 2024

Emotion recognition using the electroencephalogram (EEG) has garnered significant attention within realm of human–computer interaction due to wealth genuine emotional data stored in EEG signals. However, traditional emotion methods are deficient mining connection between multi-domain features and fitting their advantages. In this paper, we propose a novel capsule Transformer network based on feature for EEG-based recognition, referred as MES-CTNet. The model’s core consists multichannel neural network(CapsNet) embedded with ECA (Efficient Channel Attention) SE (Squeeze Excitation) blocks Transformer-based temporal coding layer. Firstly, map is constructed by combining space–frequency–time characteristics inputs model. Then, local extracted from maps improved CapsNet. Finally, layer utilized globally perceive information continuous time slices obtain final state. paper fully experimented two standard datasets different labels, DEAP SEED datasets. On dataset, MES-CTNet achieved an average accuracy 98.31% valence dimension 98.28% arousal dimension; it 94.91% cross-session task demonstrating superior performance compared methods. method, utilizing proposed herein, offers broader observation perspective recognition. It significantly enhances classification rate, thereby holding considerable theoretical practical value domain.

Language: Английский

---

A thalamo-centric neural signature for restructuring negative self-beliefs

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(3), P. 1611 - 1617

Published: Jan. 1, 2022

Negative self-beliefs are a core feature of psychopathology. Despite this, we have limited understanding the brain mechanisms by which negative cognitively restructured. Using novel paradigm, had participants use Socratic questioning techniques to restructure beliefs during ultra-high resolution 7-Tesla functional magnetic resonance imaging (UHF 7 T fMRI) scanning. Cognitive restructuring elicited prominent activation in fronto-striato-thalamic circuit, including mediodorsal thalamus (MD), group deep subcortical nuclei believed synchronize and integrate prefrontal cortex activity, but has seldom been directly examined with fMRI due its small size. Increased activity was also identified medial (MPFC), region consistently activated internally focused mental processing, as well lateral regions associated regulating emotional reactivity. Dynamic Causal Modelling (DCM), evidence found support MD having strong excitatory effect on within broader network mediating cognitive restructuring. Moreover, degree modulated MPFC-to-MD effective connectivity predicted their individual tendency engage repetitive thinking. Our findings represent major shift from cortico-centric framework cognition provide important mechanistic insights into how facilitates key processes interventions for common psychiatric disorders. In addition relaying integrative information across basal ganglia cortex, propose multifaceted role whose broad pathways act increase synchrony between cortical sustain complex representations, self.

Language: Английский

---

The longitudinal trajectory of emotion regulation and associated neural activity in patients with bipolar disorder: A prospective fMRI study

Acta Psychiatrica Scandinavica, Journal Year: 2022, Volume and Issue: 146(6), P. 568 - 582

Published: Aug. 15, 2022

Impaired emotion regulation is a key feature of bipolar disorder (BD) that presents during acute mood episodes and in remission. The neural correlates voluntary seem to involve deficient prefrontal top-down already at BD illness onset. However, the trajectory aberrant neuronal activity unclear.

Language: Английский

---