A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers DOI Creative Commons
Ofer Perl, Anastasia Shuster, Matthew Heflin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 19, 2022

Abstract Could non-pharmacological constructs, such as beliefs, impact brain activities in a dose-dependent manner drugs do? While beliefs shape many aspects of our behavior and wellbeing, the precise mapping between subjective neural substrates remains elusive. Here, nicotine-addicted humans were instructed to think that an electronic cigarette (e-cigarette) contained either “low”, “medium”, or “high” levels nicotine, while nicotine content was kept constant. After vaping e-cigarette, participants performed decision-making task known engage circuits affected by being scanned fMRI. Activity thalamus, key binding site for increased parametrically according belief dosage. Furthermore, functional coupling thalamus ventromedial prefrontal cortex, region implicated value state representations, also scaled These findings illustrate relationship thalamic circuit nicotine-related humans, mechanism previously only apply pharmacological agents.

Language: Английский

The mediodorsal thalamus in executive control DOI
Mathieu Wolff, Michael M. Halassa

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 893 - 908

Published: Jan. 30, 2024

Language: Английский

Citations

23
Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia DOI Creative Commons

Laura Benoit,

Sarah Canetta,

Christoph Kellendonk

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(6), P. 491 - 500

Published: March 14, 2022

Language: Английский

Citations

27
Dynamic subcortical modulators of human default mode network function DOI Creative Commons
Ben J. Harrison, Christopher G. Davey, Hannah S. Savage

et al.

Cerebral Cortex, Journal Year: 2021, Volume and Issue: 32(19), P. 4345 - 4355

Published: Nov. 30, 2021

The brain's "default mode network" (DMN) enables flexible switching between internally and externally focused cognition. Precisely how this modulation occurs is not well understood, although it may involve key subcortical mechanisms, including hypothesized influences from the basal forebrain (BF) mediodorsal thalamus (MD). Here, we used ultra-high field (7 T) functional magnetic resonance imaging to examine involvement of BF MD across states task-induced DMN activity modulation. Specifically, mapped suppression ("deactivation") when participants transitioned rest task performance, as engagement ("activation") performance was (i.e., self) focused. Consistent with recent rodent studies, showed overall cortical regions comparing external conditions. Further analyses, dynamic causal modeling, confirmed that drove changes in during these rest-to-task transitions. MD, by comparison, specifically engaged cognition demonstrated a broad excitatory influence on activation. These results provide first direct evidence humans distinct thalamic circuit control function suggest novel mechanistic avenues for ongoing translational research.

Language: Английский

Citations

31
Major depressive disorder associated alterations in the effective connectivity of the face processing network: a systematic review DOI Creative Commons
Alec Jamieson, Christine A. Leonards, Christopher G. Davey

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 25, 2024

Major depressive disorder (MDD) is marked by altered processing of emotional stimuli, including facial expressions. Recent neuroimaging research has attempted to investigate how these stimuli alter the directional interactions between brain regions in those with MDD; however, methodological heterogeneity made identifying consistent effects difficult. To address this, we systematically examined studies investigating MDD-associated differences present effective connectivity during We searched five databases: PsycINFO, EMBASE, PubMed, Scopus, and Web Science, using a preregistered protocol (registration number: CRD42021271586). Of 510 unique screened, 17 met our inclusion criteria. These identified that compared healthy controls, participants MDD demonstrated (1) reduced from dorsolateral prefrontal cortex amygdala negatively valenced expressions, (2) increased inhibitory ventromedial happy Most anterior cingulate noted their connectivity; precise nature was inconsistent studies. As such, commonalities observed across modalities warrant careful investigation determine specificity particular subregions Future examining longitudinal changes associated treatment response may provide important insights into mechanisms underpinning therapeutic interventions, thus enabling more targeted strategies.

Language: Английский

Citations

5
Differential engagement of the posterior cingulate cortex during cognitive restructuring of negative self- and social beliefs DOI Creative Commons
James Agathos, Trevor Steward, Christopher G. Davey

et al.

Social Cognitive and Affective Neuroscience, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 1, 2023

Negative self-beliefs are a core feature of psychopathology, encompassing both negative appraisals about oneself directly (i.e. self-judgment) and inferences how the self is appraised by others social judgment). Challenging maladaptive via cognitive restructuring treatment mechanism gold-standard psychotherapies. However, neural mechanisms underlying these two kinds poorly understood. Eighty-six healthy participants cognitively restructured self-judgment social-judgment self-belief statements during 7 Tesla functional magnetic resonance imaging scanning. Cognitive broadly elicited activation in default mode network (DMN), salience frontoparietal control regions. Restructuring relative to beliefs was associated with comparatively higher ventral posterior cingulate cortex (PCC)/retrosplenial cortex, while challenging dorsal PCC/precuneus. While regions showed increased connectivity supplementary pre-supplementary motor areas restructuring, PCC displayed greater task-dependent distributed involved salience, attention cognition. Our findings indicate distinct patterns engagement contingent upon self- domains, highlighting specialized role supporting interactions between DMN frontoparietal/salience networks restructuring.

Language: Английский

Citations

11
Frontoamygdalar Effective Connectivity in Youth Depression and Treatment Response DOI Creative Commons
Po-Han Kung, Christopher G. Davey, Ben J. Harrison

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 94(12), P. 959 - 968

Published: June 20, 2023

BackgroundEmotion regulation deficits are characteristic of youth depression and underpinned by altered frontoamygdalar function. However, the causal dynamics pathways in how they relate to treatment prognosis remain unexplored. This study aimed assess effective connectivity during cognitive reappraisal youths with test whether pathway predictive individual response combined behavioral therapy (CBT) plus fluoxetine or placebo treatment.MethodsOne hundred seven young people moderate-to-severe 94 healthy controls completed a functional magnetic resonance imaging task. After task, 87 participants were randomized received 12 weeks CBT, either placebo. Dynamic modelling was used map capacity baseline on diagnosis post-treatment remission.ResultsYoung showed weaker inhibitory modulation vlPFC-to-amygdala (0.29 Hz, posterior probability = 1.00). Leave-one-out cross-validation demonstrated that this effect sufficiently large predict diagnostic status (r .20, p .003). Post-treatment remission associated excitatory vmPFC-to-amygdala (-0.56 1.00) at baseline, though did not -.02, .561).ConclusionsFrontoamygdalar shows promise identifying diagnosis, circuits responsible for negative affect is implicated responsiveness first-line treatments.

Language: Английский

Citations

10
Habenula neural circuitry drives negative self-cognitions DOI Creative Commons
Trevor Steward, Po-Han Kung, Matthew D. Greaves

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Self-related cognitions are integral to personal identity and psychological wellbeing. Persistent engagement with negative self-cognitions can precipitate mental ill health; whereas the ability restructure them is protective. Here, we leverage ultra-high field 7T fMRI dynamic causal modelling characterise a self-cognition network centred on habenula – small midbrain region linked encoding of punishment outcomes. We model effective connectivity in discovery sample healthy young adults (n = 48) replication cohort 56) using novel cognitive restructuring task during which participants repeated or restructured self-cognitions. The elicits an excitatory effect from posterior orbitofrontal cortex that reliably observed across both samples. Furthermore, identify cingulate repeating Our study provides first evidence humans demonstrating habenula’s contribution processing These findings yield insights into function beyond external reward/punishment include abstract internal experiences.

Language: Английский

Citations

0
Habenula contributions to negative self-cognitions DOI Creative Commons
Po-Han Kung, Matthew D. Greaves, Eva Guerrero-Hreins

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 7, 2025

Language: Английский

Citations

0
Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state DOI Creative Commons
Masaya Misaki, Aki Tsuchiyagaito, Salvador M. Guinjoan

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 340, P. 843 - 854

Published: Aug. 13, 2023

Language: Английский

Citations

8
The influence of the subcortex and brain stem on overeating: How advances in functional neuroimaging can be applied to expand neurobiological models to beyond the cortex DOI Creative Commons
Po-Han Kung, Carles Soriano‐Mas, Trevor Steward

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2022, Volume and Issue: 23(4), P. 719 - 731

Published: April 5, 2022

Abstract Functional neuroimaging has become a widely used tool in obesity and eating disorder research to explore the alterations neurobiology that underlie overeating binge behaviors. Current traditional neurobiological models underscore importance of impairments brain systems supporting reward, cognitive control, attention, emotion regulation as primary drivers for overeating. Due technical limitations standard field strength functional magnetic resonance imaging (fMRI) scanners, human date focused largely on cortical basal ganglia effects appetitive The present review draws animal highlight how neural signaling encoding energy regulation, reward-learning, habit formation converge hypothalamic, brainstem, thalamic, striatal regions contribute humans. We also consider role such mediodorsal thalamus, ventral striatum, lateral hypothalamus locus coeruleus formation, inhibitory control food craving, attentional biases. Through these discussions, we proposals underlying processes could be examined using ultra-high 7-Tesla (7 T) fMRI may leveraged elucidate potential subcortical networks. Focus is given interactions with peripheral endocannabinoids neuropeptides, orexin, explored. Technical methodological aspects regarding use 7 T study behaviors are reviewed.

Language: Английский

Citations

12