Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain DOI Creative Commons

Zhuang Peng,

Sha Peng, Kangguang Lin

et al.

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: July 14, 2022

Depression is a recurrent and devastating mental disease that highly prevalent worldwide. Prolonged exposure to stressful events or environment detrimental health. In recent years, an inflammatory hypothesis has been implicated in the pathogenesis of stress-induced depression. However, less attention given initial phases, when series stress reactions immune responses are initiated. Peripheral CD4+ T cells have reported as major contributors occurrence disorders. Chronic exposure-evoked release cytokines can promote differentiation peripheral into various phenotypes. Among them, Th17 attracted much due their high pathogenic potential central nervous system (CNS) diseases. Thus, we intended determine crucial role development specific subtypes depression unravel underpinnings pathogenetic effect.In present research, daily 6-h restraint paradigm was employed rats for 28 successive days mimic repeated mild predictable, but inevitable environmental our lives. Then, depressive-like symptoms, brain-blood barrier (BBB) permeability, neuroinflammation, functional changes were investigated.We noticed restrained showed significant concomitant BBB disruption neuroinflammation dorsal striatum (DS). We further observed time-dependent increase thymus- spleen-derived naïve cells, well aggregation DS during period chronic (CRS) exposure. Moreover, increased Th17-derived brain impair integrity, thus allowing more gain easy access CNS. Our findings suggested that, through complex cascade events, propagated CNS, gradually exacerbated symptoms. Furthermore, inhibiting function with SR1001 early stages CRS ameliorated CRS-induced behaviour response.Our data demonstrated pivotal accelerating onset exacerbation depressive symptoms CRS-exposed rats. This subtype may be promising therapeutic target treatment

Language: Английский

The dopamine motive system: implications for drug and food addiction DOI
Nora D. Volkow, Roy A. Wise, Rubén Baler

et al.

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(12), P. 741 - 752

Published: Nov. 16, 2017

Language: Английский

Citations

809
Giotto: a toolbox for integrative analysis and visualization of spatial expression data DOI Creative Commons
Ruben Dries, Qian Zhu, Rui Dong

et al.

Genome biology, Journal Year: 2021, Volume and Issue: 22(1)

Published: March 8, 2021

Abstract Spatial transcriptomic and proteomic technologies have provided new opportunities to investigate cells in their native microenvironment. Here we present Giotto, a comprehensive open-source toolbox for spatial data analysis visualization. The module provides end-to-end by implementing wide range of algorithms characterizing tissue composition, expression patterns, cellular interactions. Furthermore, single-cell RNAseq can be integrated cell-type enrichment analysis. visualization allows users interactively visualize outputs imaging features. To demonstrate its general applicability, apply Giotto datasets encompassing diverse platforms.

Language: Английский

Citations

642
Cell Densities in the Mouse Brain: A Systematic Review DOI Creative Commons
Daniel Keller,

Csaba Erö,

Henry Markram

et al.

Frontiers in Neuroanatomy, Journal Year: 2018, Volume and Issue: 12

Published: Oct. 23, 2018

The mouse brain is the most extensively studied of all species. We performed an exhaustive review literature to establish our current state knowledge on cell numbers in regions, arguably fundamental property measure when attempting understand a brain. synthesized information, collected one place, can be used by both theorists and experimentalists. Although for commonly-studied regions densities could obtained principal types, overall we know very little about how many cells are present even less cell-type specific densities. There also substantial variation density values from different sources. This suggests that need new approach obtain datasets

Language: Английский

Citations

332
Social brain, social dysfunction and social withdrawal DOI
Stefano Porcelli, Nic J.A. van der Wee,

Steven van der Werff

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 97, P. 10 - 33

Published: Sept. 21, 2018

Language: Английский

Citations

326
Human organoids in basic research and clinical applications DOI Creative Commons
Xiaoyan Tang,

Shanshan Wu,

Da Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: May 24, 2022

Abstract Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult (AdSCs) derived healthy individuals patients that recapitulate the cellular heterogeneity, structure, and functions of organs. The advent 3D organoid systems is now possible to allow remarkably detailed observation cell morphogens, maintenance differentiation resemble primary tissues, enhancing potential study both physiology developmental stage. As they similar their original organs carry genetic information, organoids patient hold great promise for biomedical research preclinical drug testing currently used personalized, regenerative medicine, gene repair transplantation therapy. In recent decades, researchers have succeeded generating various types mimicking vivo Herein, we provide an update on current technologies brain, retinal, kidney, liver, lung, gastrointestinal, cardiac, vascularized multi-lineage organoids, discuss differences between PSC- AdSC-derived summarize applications cell-derived laboratory clinic, outline challenges application which would deepen understanding mechanisms development enhance further utility basic clinical studies.

Language: Английский

Citations

244
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function DOI Open Access
Nicholas M. Barnes, Gerard P. Ahern, Carine Bécamel

et al.

Pharmacological Reviews, Journal Year: 2020, Volume and Issue: 73(1), P. 310 - 520

Published: Dec. 22, 2020

5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure function reflects important role play physiologic pathophysiological processes. The present review offers a framework official receptor nomenclature detailed understanding each 14 subtypes, their roles systems body, and, where appropriate, (potential) utility targeting these receptors.

Significance Statement

This provides comprehensive account classification 5-hydroxytryptamine receptors, including how they targeted therapeutic benefit.

Language: Английский

Citations

206
Homeostasis Meets Motivation in the Battle to Control Food Intake DOI Creative Commons
Carrie R. Ferrario, Gwenaël Labouèbe, Shuai Liu

et al.

Journal of Neuroscience, Journal Year: 2016, Volume and Issue: 36(45), P. 11469 - 11481

Published: Nov. 9, 2016

Signals of energy homeostasis interact closely with neural circuits motivation to control food intake. An emerging hypothesis is that the transition maladaptive feeding behavior seen in eating disorders or obesity may arise from dysregulation these interactions. Focusing on key brain regions involved intake (ventral tegmental area, striatum, hypothalamus, and thalamus), we describe how activity specific cell types embedded within can influence distinct components motivated behavior. We review signals behavioral output present evidence experience-dependent adaptations represent cellular correlates impaired control. Future research into mechanisms restore balance between inspire new treatment options for obesity.

Language: Английский

Citations

197
Back to the inverted-U for music preference: A review of the literature DOI Open Access
Anthony Chmiel, Emery Schubert

Psychology of Music, Journal Year: 2017, Volume and Issue: 45(6), P. 886 - 909

Published: April 11, 2017

This study investigated the inverted-U model of preference for music as a function collative variables (especially familiarity and complexity) over last 115 years. The results 57 studies on were categorized according to their patterns preference. Fifty (87.7%) compatible with an overarching (segmented) model, while five (8.8%) interpreted mixed, showing both incompatible results. Two (3.5%) completely model. In contrast authors who describe defunct, this review has observed that producing are still prevalent. We propose there may be inconsistencies Berlyne’s psychobiological theory from scientific, arousal-based standpoint, is able explain considerable amount data. Rather, it seems research interests have moved elsewhere, but caution urged in asserting denial or dismissal relationship research.

Language: Английский

Citations

193
The Anatomy of Inference: Generative Models and Brain Structure DOI Creative Commons
Thomas Parr, Karl Friston

Frontiers in Computational Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: Nov. 13, 2018

To infer the causes of its sensations, brain must call on a generative (predictive) model. This necessitates passing local messages between populations neurons to update beliefs about hidden variables in world beyond sensory samples. It also entails inferences how we will act. Active inference is principled framework that frames perception and action as approximate Bayesian inference. has been successful accounting for wide range physiological behavioural phenomena. Recently, process theory emerged attempts relate their neurobiological substrates. In this paper, review develop anatomical aspects theory. We argue form models required constrains way which regions connect one another. Specifically, neuronal representing variable receive input from Markov blanket variable. illustrate idea four different domains: perception, planning, attention, movement. doing so, attempt show appealing enables us account architectures. Ultimately, committing an ensures can empirical hypotheses be tested using neuroimaging, neuropsychological, electrophysiological experiments.

Language: Английский

Citations

188
Discriminating schizophrenia using recurrent neural network applied on time courses of multi-site FMRI data DOI Creative Commons
Weizheng Yan, Vince D. Calhoun, Ming Song

et al.

EBioMedicine, Journal Year: 2019, Volume and Issue: 47, P. 543 - 552

Published: Aug. 13, 2019

Current fMRI-based classification approaches mostly use functional connectivity or spatial maps as input, instead of exploring the dynamic time courses directly, which does not leverage full temporal information.Motivated by ability recurrent neural networks (RNN) in capturing information sequences, we propose a multi-scale RNN model, enables between 558 schizophrenia and 542 healthy controls using fMRI independent components (ICs) directly. To increase interpretability, also leave-one-IC-out looping strategy for estimating top contributing ICs.Accuracies 83·2% 80·2% were obtained respectively multi-site pooling leave-one-site-out transfer classification. Subsequently, dorsal striatum cerebellum contribute two group-discriminative courses, is true even when adopting different brain atlases to extract series.This first attempt apply model directly on mental disorders, shows potential RNN-based neuroimaging classifications. FUND: Natural Science Foundation China, Strategic Priority Research Program Chinese Academy Sciences, National Institutes Health Grants, Foundation.

Language: Английский

Citations

152