Toxicology in Vitro, Journal Year: 2016, Volume and Issue: 40, P. 66 - 78
Published: Dec. 12, 2016
Language: Английский
Pediatric Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Abstract Cell therapies as treatments for neonatal conditions have attracted significant research and parent interest over the last two decades. Mesenchymal stromal cells, umbilical cord blood cells neural stem translate from lab, to preclinical into clinical trials, with contributions being made all world. Effective timely translation involves frequent reflection consultation research-adjacent fields (i.e. cell cerebral palsy, adult neurology, companies, regulatory bodies) well meaningful involvement of people lived experience. Progress date suggests that aligning outcome data reporting in later phase trials will support our sector, involving industry partners streamlined solutions manufacturing, commercialisation processes. Importantly, field can also benefit resource sharing collaboration novel drug therapies, small molecules extracellular vesicles we attempt bridge research. In this review, present highlights learnings second Neonatal Therapies Symposium (2024), held Sydney, Australia. Impact Multiple therapy candidates advanced through neonatology, showing promising feasibility, safety efficacy. is enabled by across fields, commercial partnerships, harmonising outcomes on potential utility further translational considerations are discussed paper.
Language: Английский
Citations
1
Life, Journal Year: 2025, Volume and Issue: 15(3), P. 365 - 365
Published: Feb. 26, 2025
Background: Thyroid hormones are essential for the proper functioning of female reproductive system. Seasonal changes in thyroid women age not fully understood. we aimed to investigate seasonal thyrotrophin and age. Methods: Approximately 75,000 TSH hormone levels measured 32,935 between 2019 2023 were evaluated on a monthly basis. The analysis means (ANOM) method was utilized compare mean transformed rank each group or overall TSH, FT3, FT4 values across months seasons. Results: differences from maximum minimum median 13.3% 5.2% free T3, 5.9% T4. significantly lower summer autumn higher winter spring than mean. rate individuals with below 2.5 mIU/L winter. Conclusions: varies seasonally It is appropriate consider season as well other parameters that affect functions while evaluating hormones.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2199 - 2199
Published: Feb. 28, 2025
Maternal hormonal and metabolic disorders, such as diabetes obesity, can adversely affect the intrauterine environment, resulting in suboptimal fetal growth an elevated risk of cardiovascular diseases later life offspring. In this review, we examine long-term impact maternal androgen levels during pregnancy on hyperandrogenemia is linked to various neurodevelopmental including attention-deficit/hyperactivity disorder, autism spectrum anxiety-like behaviors, mediated by alterations key brain regions responsible for emotion cognition. Furthermore, children born mothers with exhibit heightened dysfunctions, insulin resistance, hypertension, which manifest early life. Prenatal exposure androgens has also been reduced birth weights altered growth, potentially due impaired placental function. Additionally, testosterone influence offspring sex ratios, often favoring male births, though exceptions occur certain conditions, congenital adrenal hyperplasia. The findings review underscore need healthcare professionals monitor serum profiles pregnancy. Further research needed determine underlying mechanisms potential interventions mitigate these risks.
Language: Английский
Citations
1
Environment International, Journal Year: 2017, Volume and Issue: 106, P. 11 - 18
Published: May 30, 2017
Language: Английский
Citations
81
Toxicology in Vitro, Journal Year: 2016, Volume and Issue: 40, P. 66 - 78
Published: Dec. 12, 2016
Language: Английский
Citations
72