Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies DOI Creative Commons
Alexey Sarapultsev, Maria Komelkova, Oleg Lookin

et al.

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(4), P. 709 - 760

Published: Dec. 6, 2024

Post-Traumatic Stress Disorder (PTSD) is a multifaceted psychiatric disorder triggered by traumatic events, leading to prolonged psychological distress and varied symptoms. Rat models have been extensively used explore the biological, behavioral, neurochemical underpinnings of PTSD. This review critically examines strengths limitations commonly rat models, such as single stress (SPS), stress–re-stress (S-R), predator-based paradigms, in replicating human PTSD pathology. While these provide valuable insights into neuroendocrine responses, genetic predispositions, potential therapeutic targets, they face challenges capturing full complexity PTSD, particularly terms ethological relevance translational validity. We assess degree which mimic neurobiological behavioral aspects highlighting areas where succeed fall short. also discusses future directions refining improve their utility for research, aiming bridge gap between preclinical findings clinical applications.

Language: Английский

A Behavioral Screening Method for Predicting PTSD-like Phenotypes: Novel Application to Female Rats DOI
Giulia Chiacchierini, Giulia Federica Mancini,

Benedetta Di Cesare

et al.

Journal of Neuroscience Methods, Journal Year: 2025, Volume and Issue: unknown, P. 110380 - 110380

Published: Jan. 1, 2025

Language: Английский

Citations

0
Preclinical Behavioral and Pharmacological Treatments for Enhancing Fear Extinction in Adolescence DOI Creative Commons

Emily K. Wall,

Elizabeth A Virakorn, Kathryn Baker

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106090 - 106090

Published: March 1, 2025

Adolescence is a window of vulnerability for the development anxiety disorders but also opportunity treatments to minimize long-term impact such disorders. Current first-line treatments, primarily exposure-based cognitive-behavioral therapy (CBT), have limited efficacy in adolescents. The urgent need more effective interventions underscored by frequent reports extinction impairments adolescents as well rising rates youth, particularly post-COVID-19. Preclinical research on learned fear may contribute developing better treatment approaches this age group. Unfortunately, still largely under-explored area. However, both pharmacological and behavioral augmentation strategies can be used enhance learning consolidation. Here we describe work exploring adjuncts, focusing pre-clinical with rodents. Much date shows striking developmental differences response various only few shown Further, recent experience stress reduces these adolescence. This review highlights necessity tailored strategies, especially when it comes that address drug responses stressful experiences efficacy.

Language: Английский

Citations

0
Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies DOI Creative Commons
Alexey Sarapultsev, Maria Komelkova, Oleg Lookin

et al.

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(4), P. 709 - 760

Published: Dec. 6, 2024

Post-Traumatic Stress Disorder (PTSD) is a multifaceted psychiatric disorder triggered by traumatic events, leading to prolonged psychological distress and varied symptoms. Rat models have been extensively used explore the biological, behavioral, neurochemical underpinnings of PTSD. This review critically examines strengths limitations commonly rat models, such as single stress (SPS), stress–re-stress (S-R), predator-based paradigms, in replicating human PTSD pathology. While these provide valuable insights into neuroendocrine responses, genetic predispositions, potential therapeutic targets, they face challenges capturing full complexity PTSD, particularly terms ethological relevance translational validity. We assess degree which mimic neurobiological behavioral aspects highlighting areas where succeed fall short. also discusses future directions refining improve their utility for research, aiming bridge gap between preclinical findings clinical applications.

Language: Английский

Citations

1