Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
Language: Английский
Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 116, P. 52 - 61
Published: Nov. 27, 2023
Language: Английский
Citations
17
Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 457, P. 122884 - 122884
Published: Jan. 17, 2024
Language: Английский
Citations
7
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 192, P. 106416 - 106416
Published: Jan. 23, 2024
The dysregulation of the gut-brain axis in chronic inflammatory bowel diseases can cause neuro-psychological disturbances, but underlying mechanisms are still not fully understood. choroid plexus (CP) maintains brain homeostasis and nourishment through secretion clearance cerebrospinal fluid. Recent research has demonstrated existence a CP vascular barrier mice which is modulated during intestinal inflammation. This study investigates possible correlations between modifications activity patients with Crohn's disease (CD). In this prospective study, 17 CD underwent concomitant abdominal 3 T MRI. volume permeability were compared levels C-reactive protein (CRP), fecal calprotectin (FC), sMARIA SES-CD scores. was negatively correlated CRP (R = -0.643, p-value 0.024) FC -0.571, 0.050). DCE metrics normalized by positively (K-trans: R 0.587, 0.045; Vp: 0.706, 0.010; T1: 0.699, 0.011), (Vp: 0.606, 0.037). Inflammatory associated changes permeability, thus supporting hypothesis that inflammation could affect modulation also humans.
Language: Английский
Citations
7
Journal of Neuroradiology, Journal Year: 2023, Volume and Issue: 51(4), P. 101164 - 101164
Published: Oct. 30, 2023
Language: Английский
Citations
15
Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14
Published: March 8, 2023
Introduction Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease. In this pilot study, we aimed to elucidate association between longitudinal changes CP volume, sex and cognitive impairment. Methods We assessed volume a cohort n = 613 subjects across 2,334 datapoints from ADNI 2 ADNI-GO, belonging cognitively unimpaired (CN), stable mild impairment (MCI), clinically diagnosed disease dementia (AD) or convertor (to either AD MCI) subgroups. was automatically segmented used as response variable linear mixed effect models with random intercept clustered by patient identity. Temporal effects select variables were interactions subgroup analyses. Results found an overall significant increase time (14.92 mm 3 per year, 95% confidence interval, CI (11.05, 18.77), p < 0.001). Sex-disaggregated results showed annual rate 9.48 males [95% (4.08, 14.87), 0.001], 20.43 females (14.91, 25.93), indicating more than double females, which appeared independent other temporal variables. The only diagnostic group compared CN convertors group, 24.88 /year (14, 35.82), 0.001]. ApoE exhibited effect, E4 homozygote group’s increasing at triple non-carrier heterozygote groups [40.72, (25.97, 55.46), 0.001 vs. 12.52, (8.02, 17.02), for homozygotes non-carriers, respectively], may modified relationship. Conclusion Our contribute potential differences novel finding twice choroid enlargement provide putative support CP-related deterioration its relationship E4.
Language: Английский
Citations
13
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(12), P. 10398 - 10447
Published: May 10, 2024
Language: Английский
Citations
6
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 117, P. 255 - 269
Published: Jan. 26, 2024
Language: Английский
Citations
5
European Radiology Experimental, Journal Year: 2024, Volume and Issue: 8(1)
Published: Feb. 27, 2024
Abstract We compared choroid plexus (ChP) manual segmentation on non-contrast-enhanced (non-CE) sequences and reference standard CE T1- weighted (T1w) in 61 multiple sclerosis patients prospectively included. ChP was separately segmented T1w, T2-weighted (T2w) fluid-attenuated inversion-recovery (FLAIR), CE-T1w sequences. Inter-rater variability assessed 10 subjects showed high reproducibility between measured by intraclass correlation coefficient (T1w 0.93, FLAIR 0.99). higher signal-to-noise ratio contrast-to-noise (CE-T1w 23.77 18.49, T1w 13.73 7.44, 13.09 10.77, respectively). Manual of resulted 3.073 ± 0.563 mL (mean deviation) 3.787 0.679 FLAIR, 2.984 0.506 images, with an error 28.02 19.02% for 3.52 12.61% T1w. overestimated volume to ( p < 0.001). The Dice similarity versus 0.67 0.05 0.68 0.05, respectively. Spatial distribution per slice calculated after nonlinear coregistration the MNI152 space a heterogeneous profile along especially near fornix hippocampus. Quantitative analyses suggest as surrogate estimate volume. Relevance statement To volume, can be replaced non-CE because is acceptable, while overestimates This encourages development automatic tools segmentation, also improving understanding role sclerosis, promoting longitudinal studies. Key points • are considered segmentation. CNR than but Non-CE ChP. Graphical
Language: Английский
Citations
5
Schizophrenia, Journal Year: 2023, Volume and Issue: 9(1)
Published: Feb. 25, 2023
Abstract Extensive research has established the presence of resting-state brain functional damage in psychosis. However, genetic mechanisms such disease phenotype are yet to be unveiled. We investigated alterations patients with drug-naive first-episode psychosis (DFP) by performing a neuroimaging meta-analysis 8 original studies comprising 500 and 469 controls. Combined Allen Human Brain Atlas, we further conducted transcriptome-neuroimaging spatial correlations identify genes whose expression levels were linked DFP, followed range gene characteristic analyses. Meta-analysis revealed mixture increased decreased function widespread areas including default-mode, visual, motor, striatal, cerebellar systems DFP. Moreover, these spatially associated 1662 genes, which enriched for molecular functions, cellular components, biological processes cerebral cortex, as well psychiatric disorders schizophrenia. Specific analyses demonstrated that specifically expressed tissue, cortical neurons immune cells, during nearly all developmental periods. Concurrently, could construct protein-protein interaction network supported hub multiple behavioral domains emotion, attention, perception, motor. Our findings provide empirical evidence notion DFP involves complex polygenes various characteristics.
Language: Английский
Citations
11
Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 111, P. 292 - 297
Published: May 5, 2023
The choroid plexus (CP) produces and secretes most of the cerebrospinal fluid (CSF) central nervous system. CP is suggested to be regulated by descending neurons circulating factors involved in interaction between peripheral inflammation. Quantitative imaging has demonstrated volumetric changes psychosis, schizophrenia depression. This study histologically examines epithelial cell morphology these illnesses identify biological source such changes.Formalin-fixed paraffin-embedded (FFPE) blocks were obtained bilaterally from lateral ventricles 13 cases sex- age-matched brains each (SZ) with major depressive disorder (MDD) matched controls (NPD). FFPE sectioned at 7 μm routinely stained for H&E. Morphological analysis 180 epithelia/case was conducted blindly on digital images collected x600 magnification. Calcification assessed all regions manually.Analysis a General Linear Model significant effect diagnosis somal width (p = 0.006, R2 0.33 R2(adj) 0.25) demonstrating increased SZ without psychotic medication versus 0.032), but not medicated cases. No effects observed calcification.The cells that examined attached fibrous surface, so expansion describes primary methods expand adherence this surface SZ. antipsychotic demonstrates an illness-specific change mediated through DA-system likely neuronal origin. alterations found MDD where they are instead generally associated heightened allostatic load unknown cohort.
Language: Английский
Citations
11