Multivariate mapping of low-resilient neurocognitive systems within and around low-grade gliomas

Brain, Journal Year: 2024, Volume and Issue: 147(8), P. 2718 - 2731

Published: April 22, 2024

Accumulating evidence suggests that the brain exhibits a remarkable capacity for functional compensation in response to neurological damage, resilience potential is deeply rooted malleable features of its underlying anatomofunctional architecture. This propensity particularly exemplified by diffuse low-grade glioma, subtype primary tumour. However, plasticity not boundless, and surgical resections directed at structures with limited neuroplasticity can lead incapacitating impairments. Yet, maximizing glioma offers substantial oncological benefits, especially when resection extends beyond tumour margins (i.e. supra-tumour or supratotal resection). In this context, objective study was identify which cerebral were associated less favourable cognitive outcomes after surgery, while accounting intra-tumour resections. To achieve objective, we leveraged unique cohort 400 patients who underwent surgery awake mapping. Patients benefitted from neuropsychological assessment consisting 18 subtests administered before 3 months surgery. We analysed changes performance applied topography-focused disconnection-focused multivariate lesion-symptom mapping using support vector regressions, an attempt capture resected cortico-subcortical amenable full compensation. The observed magnitude, suggesting overall recovery (13 tasks recovered fully despite mean extent 92.4%). Nevertheless, analyses revealed lack picture naming linked damage left inferior temporal gyrus longitudinal fasciculus. Likewise, semantic fluency abilities, association established precuneus/posterior cingulate. For phonological dorsomedial frontal cortex aslant tract implicated. Moreover, difficulties spatial exploration injury right prefrontal connectivity. An exploratory analysis suggested pronounced following specific patterns, such as uncinate fasciculus (picture naming), corticostriatal anterior corpus callosum (phonological fluency), hippocampus parahippocampus (episodic memory) frontal-mesial areas (visuospatial exploration). Collectively, these patterns results shed new light on both low-resilient neural systems prediction Furthermore, they indicate only occasionally well tolerated viewpoint. doing so, have deep implications planning rehabilitation strategies.

Language: Английский

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Exploring post-rehabilitation plasticity with intra-cerebral recordings on anomic profiles

Frontiers in Language Sciences, Journal Year: 2025, Volume and Issue: 3

Published: Jan. 6, 2025

Background Patients with drug-resistant epilepsy involving the language network often exhibit anomic profiles in daily life due to difficulties lexical selection processes. Very little evidence is available regarding effects of rehabilitation this population. Objective(s) We aim induce brain plasticity combined improvements behavioral performance using therapy patients epilepsy. Methods implemented a focused on phonological and semantic features infrequent words over three treatment sessions, each targeting specific category. Intracranial signals were recorded 10 during baseline post-therapy picture-naming sessions. Response times percentages correct responses naming tests collected. Time-frequency analyses conducted intracranial signals, comparisons made between conditions for patient. Results Half demonstrated improved skills following treatment. observed significantly different recruitment frontotemporal areas left hemisphere (including Broca's area) that skills. Specifically, we found high-gamma activity posterior inferior frontal gyrus 500 ms after stimulus onset vs. non-improved This effect was not right hemisphere. Conclusions These findings suggest enhanced associated modifications IFG activations latencies closely tied process.

Language: Английский

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Deficits of Attention and Working Memory in Patients with Gliomas of Supplementary Motor Area

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1229 - 1229

Published: Feb. 13, 2025

Objectives: The effects of brain tumors located in the supplementary motor area (SMA) have so far been described mainly context and speech disorders. There are few studies that considered other cognitive domains, this study aimed to fill gap by focusing on examining attention working memory a population patients with gliomas SMA region. Methods: This included 50 diagnosed who not yet had any treatment 57 demographically matched healthy individuals. A set neuropsychological tests was conducted assess memory: Digit Span from WAIS-R, Visual Elevator TEA, Verbal Fluency Test (switching condition), Color Trails (CTT). Results: analyses showed scored lower most evaluated indicators, namely Span-forward (t = -2.05; p 0.022), Span-backward -2.63; 0.005), CTT-2 4.24; 0.001), CTT-interference 2.31; 0.012), Elevator-time 1.83; 0.035), Elevator-accuracy -2.42, 0.010), Fluency-switching -3.41; 0.001). significant relationship also demonstrated between grade tumor malignancy results achieved some tests. lateralization tumor, size lesion, presence epilepsy did prove be particularly significant. Conclusions: Due decline performance terms memory, we believe every patient should undergo detailed examination, which will profile their functioning help tailor best possible psychological care.

Language: Английский

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Oncology: Brain asymmetries in language-relevant brain tumors

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 65 - 87

Published: Jan. 1, 2025

Language: Английский

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Natural rhythmic speech activates network reorganization with frontal community enhancing communication efficiency in patients with intrinsic brain tumor

NeuroImage, Journal Year: 2025, Volume and Issue: 310, P. 121112 - 121112

Published: March 4, 2025

Brain tumors provide unique insights into brain plasticity due to their slow growth compared acute cerebrovascular diseases. Despite relying on sophisticated functional networks, patients with exhibit minimal deficits in higher language functions and demonstrate positive post-injury plasticity; however, the underlying neural mechanisms remain unclear. We utilized high-density electroencephalography investigate network tumor without evident deficits. Natural rhythmic sentences non-rhythmic contrasting speech prosodic harmony were employed examine impact of task integrativeness reorganization. Our study reveals that perception, characterized by processing integrativeness, induced inhibited engagement frontal lobe but evoked enhanced hubness modularity, which supported generation new connections promoted efficiency global connectivity. Furthermore, local invasion prompted adjacent hubs generate enriched during early phase, facilitating later findings underscore significant role reveal importance highly integrated tasks for reorganization rehabilitation.

Language: Английский

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Function-guided differences of arcuate fascicle and inferior fronto-occipital fascicle tractography as diagnostic indicators for surgical risk stratification

Brain Structure and Function, Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Abstract Background Several patients with language-eloquent gliomas face language deterioration postoperatively. Persistent aphasia is frequently associated damage to subcortical pathways. Underlying mechanisms still need be better understood, complicating preoperative risk assessment. This study compared qualitative and quantitative functionally relevant differences pre- directly postoperatively in glioma without aphasia. Methods Language-relevant cortical sites were defined using navigated transcranial magnetic stimulation (nTMS) mapping 74 between 07/2016 07/2019. Post-hoc nTMS-based diffusion tensor imaging tractography was used compare a tract’s postoperative visualization, volume fractional anisotropy (FA), the distance tract lesion overlap resection cavity following groups: no (NoA), tumor- or previous induced persistent (TIA_P), surgery-induced transient permanent (SIA_T SIA_P). Results Patients NoA, TIA_P, SIA_T, SIA_P showed distinct fasciculus arcuatus (AF) inferior-fronto-occipital (IFOF) properties. The AF more reconstructable, FA of IFOF higher NoA than TIA_P cases (all p ≤ 0.03). Simultaneously, SIA_T (p < 0.001) most considerable loss overall. While not statistically significant, four complete ventral streams postoperatively, highest resection-cavity-AF-overlap, shortest tumor distance. Conclusion Functionally provide pathophysiological clinically diagnostic indicator that supports surgical stratification.

Language: Английский

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More widespread functionality of posterior language area in patients with brain tumors

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(11)

Published: Aug. 1, 2024

Abstract Damage to the posterior language area (PLA), or Wernicke's causes cortical reorganization in corresponding regions of contralateral hemisphere. However, details within ipsilateral hemisphere are not fully understood. In this context, direct electrical stimulation during awake surgery can provide valuable opportunities investigate neuromodulation human brain vivo, which is difficult through non‐invasive approaches. Thus, study, we aimed characteristics PLA Sixty‐two patients with left hemispheric gliomas were divided into groups depending on whether lesion extended PLA. All underwent a picture‐naming task. We further performed functional connectivity analyses using resting‐state magnetic resonance imaging (MRI) subset and calculated betweenness centrality, an index network importance areas. During stimulation, showing positive (impaired) responses non‐PLA group localized mainly superior temporal gyrus (pSTG), whereas those widely distributed from pSTG supramarginal (pSMG). Notably, percentage pSMG was significantly higher (47%) than (8%). connectivity, identified as hub region high centrality both groups. These findings suggest that spread beyond pSMG, region, progression pSTG. The change pattern may be compensatory mechanism maintain efficient networks.

Language: Английский

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Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals

Brain Structure and Function, Journal Year: 2024, Volume and Issue: 229(9), P. 2187 - 2205

Published: Sept. 18, 2024

Abstract Research on the neural imprint of dual-language experience, crucial for understanding how brain processes dominant and non-dominant languages, remains inconclusive. Conflicting evidence suggests either similarity or distinction in processing, with implications bilingual patients tumors. Preserving functions after surgery requires considering pre-diagnosis neuroplastic changes. Here, we combine univariate multivariate fMRI methodologies to test a group healthy Spanish-Basque bilinguals gliomas affecting language-dominant hemisphere while they overtly produced sentences their language. Findings from participants revealed presence shared system both also identifying regions distinct language-dependent activation lateralization patterns. Specifically, language engaged more left-lateralized network, speech production relied recruitment bilateral basal ganglia-thalamo-cortical circuit. Notably, based patterns, were able robustly decode (AUC: 0.80 ± 0.18) being used. Conversely, exhibited patterns languages. For language, such as cerebellum, thalamus, caudate acted concert sparsely activated language-specific nodes. In case default mode network was notably prominent. These results demonstrate compensatory engagement non-language-specific networks preservation production, even face pathological conditions. Overall, our findings underscore pervasive impact experience functional (re)organization, health disease.

Language: Английский

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The effect of different brain lesions on the reorganization of language functions within the dominant hemisphere assessed with task-based BOLD-fMRI

La radiologia medica, Journal Year: 2023, Volume and Issue: 128(6), P. 775 - 783

Published: May 15, 2023

Language: Английский

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Structural networking of the developing brain: from maturation to neurosurgical implications

Frontiers in Neuroanatomy, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 30, 2023

Modern neuroscience agrees that neurological processing emerges from the multimodal interaction among multiple cortical and subcortical neuronal hubs, connected at short long distance by white matter, to form a largely integrated dynamic network, called brain "connectome." The final architecture of these circuits results complex, continuous, highly protracted development process several axonal pathways constitute anatomical substrate interactions. Awareness network organization central nervous system is crucial not only understand basis children's development, but also it may be special interest improve quality neurosurgical treatments many pediatric diseases. Although there are flourishing number neuroimaging studies connectome, comprehensive vision linking this research practice still lacking in current literature. goal review contribute bridging gap. In first part, we summarize main knowledge concerning maturation its involvement different aspects normal neurocognitive as well pathophysiology specific section devoted identifying possible implications field, especially epilepsy tumor surgery, discuss promising perspectives for future investigations.

Language: Английский

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