Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories DOI Open Access
Kevin J. Clancy, Quentin Devignes, Boyu Ren

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 22, 2023

ABSTRACT Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, their underlying mechanisms have been investigated separate from properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions vary along the anterior-posterior axis hippocampus (HPC) support different cognitive-affective and sensory-perceptual features memory. Extending this work into TR-IMs, we conducted a study eighty-four trauma-exposed adults who completed daily ecological momentary assessments TR-IM followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics anterior posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis investigate associations with TR-IMs. Emotional intensity was inversely associated frequency persistence an aHPC-default mode network pattern. Conversely, sensory frequent HPC cortices ventral attention network, reliving in “here-and-now” persistent pHPC visual cortex. Notably, no found between HPC-cortical conventional symptom measures, including or retrospective recall, underscoring utility identifying neural substrates These findings provide novel mechanistic insights development individualized, pervasive, difficult-to-treat symptom.

Language: Английский

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories DOI Creative Commons
Kevin J. Clancy, Quentin Devignes, Boyu Ren

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(7), P. 2161 - 2169

Published: March 7, 2024

Abstract Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, their underlying mechanisms have been investigated separate from properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions vary along the anterior-posterior axis hippocampus (HPC) support different cognitive-affective and sensory-perceptual features memory. Extending this work into TR-IMs, we conducted a study eighty-four trauma-exposed adults who completed daily ecological momentary assessments TR-IM followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics anterior posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis investigate associations with TR-IMs. Emotional intensity was inversely associated frequency persistence an aHPC-default mode network pattern. Conversely, sensory frequent HPC cortices ventral attention network, reliving in “here-and-now” persistent pHPC visual cortex. Notably, no found between HPC-cortical conventional symptom measures, including or retrospective recall, underscoring utility identifying neural substrates. These findings provide novel insights correlates development individualized, pervasive, difficult-to-treat symptom.

Language: Английский

Citations

8
Defining the r factor for post-trauma resilience and its neural predictors DOI
Sanne J.H. van Rooij,

Justin L. Santos,

Cecilia A. Hinojosa

et al.

Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(6), P. 680 - 693

Published: April 22, 2024

Language: Английский

Citations

6
The promise of precision functional mapping for neuroimaging in psychiatry DOI
Damion V. Demeter, Deanna J. Greene

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 16 - 28

Published: July 31, 2024

Language: Английский

Citations

6
Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review DOI Creative Commons
Ziv Ben‐Zion, Nachshon Korem, Naomi B. Fine

et al.

Biological Psychiatry Global Open Science, Journal Year: 2023, Volume and Issue: 4(1), P. 120 - 134

Published: July 13, 2023

Numerous studies have explored the relationship between posttraumatic stress disorder (PTSD) and hippocampus amygdala because both regions are implicated in disorder's pathogenesis pathophysiology. Nevertheless, those key limbic consist of functionally cytoarchitecturally distinct substructures that may play different roles etiology PTSD. Spurred by availability automatic segmentation software, structural neuroimaging human hippocampal subregions proliferated recent years. Here, we present a preregistered scoping review existing adults diagnosed with A total 3513 assessing subregion volumes were identified, 1689 which screened, 21 eligible for this (total

Language: Английский

Citations

12
Multimodal associations between posterior hippocampus glutamate metabolism, visual cortex connectivity, and intrusive trauma reexperiencing symptoms DOI Open Access
Kevin J. Clancy, Xi Chen, Xiaopeng Song

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Objective Hippocampal dysfunction is implicated in posttraumatic stress disorder (PTSD), particularly intrusive reexperiencing symptoms, and may be mediated by glutamatergic excitotoxicity. Markers of glutamate (higher to N-acetyl aspartate levels; Glu/NAA) the hippocampus (HPC) have been linked symptoms. However, HPC demonstrates heterogeneity along its anterior-posterior axis, with different functional connectivity patterns PTSD symptom associations, motivating investigations into metabolism anterior posterior subregions (a/pHPC). Methods 121 symptomatic trauma-exposed adults (93 female) current trauma symptoms completed magnetic resonance spectroscopy resting-state imaging examine regional specificity Glu/NAA associations reexperiencing, link a/pHPC connectivity. were assessed Clinician-Administered Scale for DSM-5. Results Reexperiencing severity was associated greater pHPC, but not aHPC. pHPC further stronger between visual cortex (VC), which turn correlated more severe This strengthened pHPC-VC explained shared variance severity, suggesting dysregulated contribute through VC. Conclusions These findings replicate prior work linking provide novel evidence this association specific multimodal investigation supports translational models trauma-related disorders highlights new targets pharmacological neuromodulatory interventions.

Language: Английский

Citations

0
Intrinsic functional connectivity of right dorsolateral prefrontal cortex and hippocampus subregions relates to emotional and sensory-perceptual properties of intrusive trauma memories DOI
Quentin Devignes, Kevin J. Clancy, Boyu Ren

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health DOI Creative Commons

Felipe Rici Azarias,

Gustavo Henrique Doná Rodrigues Almeida, Luana Félix de Melo

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 395 - 395

Published: April 10, 2025

The Default Mode Network has been extensively studied in recent decades due to its central role higher cognitive processes and relevance for understanding mental disorders. This neural network, characterized by synchronized coherent activity at rest, is intrinsically linked self-reflection, exploration, social interaction, emotional processing. Our of the DMN extends beyond humans non-human animals, where it observed various species, highlighting evolutionary basis adaptive significance throughout phylogenetic history. Additionally, plays a crucial brain development during childhood adolescence, influencing fundamental processes. literature review aims provide comprehensive overview DMN, addressing structural, functional, aspects, as well impact from infancy adulthood. By gaining deeper organization function we can advance our knowledge mechanisms that underlie cognition, behavior, health. This, turn, lead more effective therapeutic strategies range neuropsychiatric conditions.

Language: Английский

Citations

0
A short-interval longitudinal study of associations between psychological distress and hippocampal grey matter in early adolescence DOI Creative Commons
Amanda Boyes, Jacob M. Levenstein, Larisa T. McLoughlin

et al.

Brain Imaging and Behavior, Journal Year: 2024, Volume and Issue: 18(3), P. 519 - 528

Published: Jan. 13, 2024

Abstract This study of Australian adolescents ( N = 88, 12-13-years-old) investigated the relationship between hippocampal grey matter volume (GMV) and self-reported psychological distress (K10) at four timepoints, across 12 months. Participants were divided into two groups; those who had K10 scores 10 15 for all timepoints categorised as “low distress” (i.e., control group; n 38), while participants 16 or higher least once over year “moderate-high 50). Associations tested by GEE fitting GMV measures same time point, in preceding subsequent timepoints. Analyses revealed smaller left larger right associated with group. was not observed In contrast, group showed significant co-occurring associations TP) scores. The experienced greater variability distress. These results suggest that development early adolescence is differently experience some point year, compared to controls. findings offer a novel way utilise short-interval, multiple time-point longitudinal data explore changes adolescents. may be linked fluctuations

Language: Английский

Citations

3
Why reliving is not remembering and the unique neurobiological representation of traumatic memory DOI
Breanne E. Kearney,

Ruth A. Lanius

Nature Mental Health, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

Citations

3
The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder DOI Creative Commons
Javed Iqbal,

Geng-Di Huang,

Yanxue Xue

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Dec. 5, 2023

Post-traumatic stress disorder (PTSD) is a stress-associated complex and debilitating psychiatric due to an imbalance of neurotransmitters in response traumatic events or fear. PTSD characterized by re-experiencing, avoidance behavior, hyperarousal, negative emotions, insomnia, personality changes, memory problems following exposure severe trauma. However, the biological mechanisms symptomatology underlying this are still largely unknown poorly understood. Considerable evidence shows that results from dysfunction highly conserved brain systems involved regulating stress, anxiety, fear, reward circuitry. This review provides contemporary update about PTSD, including new data clinical preclinical literature on fear consolidation extinction processes. First, we present overview well-established laboratory models discuss their translational value for finding various treatments PTSD. We then highlight research progress neural circuits extinction-related prefrontal cortex, hippocampus, amygdala. further describe different molecular mechanisms, GABAergic, glutamatergic, cholinergic, neurotropic signaling, responsible structural functional changes during acquisition processes

Language: Английский

Citations

8