Magnetic susceptibility of the hippocampal subfields and basal ganglia in acute mild traumatic brain injury

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Despite vulnerability to microstructural tissue damage following mild traumatic brain injury (mTBI), key subcortical regions have been overlooked in quantitative susceptibility mapping (QSM) studies. Alterations composition the functionally and structurally distinct hippocampal subfields basal ganglia may reflect symptomatology, better characterisation of these is needed in-crease our understanding mTBI pathophysiology. To address this issue, we used magnetic source-separated QSM quantify spatial distributions positive (iron-related) negative (myelin-, protein-, calcium-related) across 10 substructures 16 segmentations 25 male participants with acute (< 14 days) sports-related (sr-mTBI). Additional variables interest including age, severity, days since at time resonance imaging (MRI) scan were also correlated both values. Primary analyses indicated no significant difference values between sr-mTBI controls for ROIs. For sign values, was significantly less cornu ammonis 4 (CA4) region only ( p FDR < 0.05). In line known linear relationship iron deposition age deep grey matter sites, particularly within first three decades life, relationships observed putamen, caudate, red nucleus, parabrachial pigmented ventral pallidum Positive absolute fimbria, extended amygdala 0.05), suggesting age-related calcifications regions. A indicating potential changes myelin content region. No associations be-tween any other variable signed The results study contribute to, extend, prior literature regarding temporal kinetics biomagnetic substrates as a function ageing. Decreased after CA4 suggests injury-related effects on or cell loss; interesting finding light well-established pathology chronic encephalopathy (CTE). lack between-group differences suggest that alterations not be quantifiable stage ROIs masked by common feature all young cohort. Future research should consider use longitudinal designs mitigate influence factors.

Language: Английский

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Distribution of paramagnetic and diamagnetic cortical substrates following mild Traumatic Brain Injury: A depth- and curvature-based quantitative susceptibility mapping study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

ABSTRACT Evidence has linked head trauma to increased risk factors for neuropathology, including acute mechanical deformation of the cortical sulcal fundus and, later, perivascular accumulation hyperphosphorylated tau (p-tau) adjacent these spaces related chronic traumatic encephalopathy (CTE). Despite this, little is known about microstructural abnormalities and cellular dyshomeostasis at stage mild brain injury (mTBI) in humans, particularly cortex. To address this gap literature, we designed first architectonically-motivated quantitative susceptibility mapping (QSM) study assess regional patterns positive (iron-related) negative (myelin-, calcium-, protein-related) magnetic regions interest (ROI) following mTBI. Depth- curvature-specific QSM values were compared between 25 males with (< 14 days) sports-related mTBI (sr-mTBI) age-matched male controls across 34 ROIs. Bilateral between-group analyses conducted on specific ROI curvature bins (crown, bank, fundus) as well a combined measure, 21 depths, each ROI. Correlations analysed age, severity, number days since injury. We observed significant group differences depth, curvature, Our results suggest trauma-induced pattern likely iron deposition preferential superficial, perivascular-adjacent sulci parahip-pocampal gyrus. Co-localised decreases diamagnetism same region dual pathology neural substrates, biological mechanisms behind which remain speculative. Significant correlations found both ROIs depths distinct from those showing sr-mTBI-related differences. Little no relationship was subjective markers or latency. The coherence our findings pathognomonic misfolded proteins trauma-related neurodegeneration interesting, may have implications role tissue damage after Further longitudinal research needed elucidate long-term findings.

Language: Английский

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Characterizing positive and negative quantitative susceptibility values in the cortex following mild traumatic brain injury: a depth- and curvature-based study

Cerebral Cortex, Journal Year: 2025, Volume and Issue: 35(3)

Published: March 1, 2025

Abstract Evidence has linked head trauma to increased risk factors for neuropathology, including mechanical deformation of the sulcal fundus and, later, perivascular accumulation hyperphosphorylated tau adjacent these spaces related chronic traumatic encephalopathy. However, little is known about microstructural abnormalities and cellular dyshomeostasis in acute mild brain injury humans, particularly cortex. To address this gap, we designed first architectonically motivated quantitative susceptibility mapping study assess regional patterns net positive (iron-related) negative (myelin-, calcium-, protein-related) magnetic across 34 cortical regions interest following injury. Bilateral, between-group analyses sensitive depth curvature were conducted between 25 males with (&lt;14 d) sports-related age-matched male controls. Results suggest a trauma-induced increase focal superficial, perivascular-adjacent parahippocampal sulcus. Decreases values distinct voxel populations within same region indicate potential dual pathology neural substrates. These injury–related from age-related processes revealed by correlation analyses. Our findings depth- curvature-specific deposition biological substrates tissue convergent features misfolded proteins trauma-related neurodegeneration.

Language: Английский

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Cortical iron-related markers are elevated in mild Traumatic Brain Injury: An individual-level quantitative susceptibility mapping study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

ABSTRACT Quantitative susceptibility mapping (QSM) has been applied to map brain iron distribution after mild traumatic in-jury (mTBI), understand properties of neural tissue which may be related microstructural damage. However, mTBI is a heterogeneous injury associated with changes, and ‘traditional’ group-wise statistical approaches lead loss clinically relevant information, as subtle individual-level changes can obscured by averages confounded within-group variability. More precise individualised are needed characterise better elucidate potential cellular mechanisms improve intervention rehabilitation. To address this issue, we build profiles regional positive (iron-related) magnetic across 34 bilateral cortical regions interest (ROIs) following mTBI. Healthy population templates were constructed for each area using standardised z-scores derived from 25 age-matched male controls, serving reference against 35 males acute (< 14 days) sports-related (sr-mTBI) compared. Secondary analyses sensitive depth curvature also generated approximate the location accumulation in laminae effect gyrification. Our primary indicated that approximately one-third (11/35; 31%) participants exhibited elevated sus-ceptibility indicative abnormal relative healthy control population, finding was mainly concentrated ROIs within temporal lobe. Injury severity significantly higher (p < 0.01) these than their iron-normal counterparts, suggesting link between severity, symptom burden, iron. revealed 83% (29/35) participants, enabling localisation mTBI-related content specific loci ROI identifying effects more lost ROI-wise averaging. findings suggest further clinical relevance Differences iron-abnormal highlight not only why investigation required objective subjective symptomatology, but identify candidate biomarker damage

Language: Английский

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