Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Gas
therapy
using
gasotransmitters
is
of
exponential
interest
due
to
the
growing
recognition
gas
signaling
molecules
that
can
be
involved
in
multiple
therapeutic
actions.
Finding
suitable
methods
for
delivering
these
crucial,
and
porous
materials,
notably
metal-organic
frameworks
(MOFs),
have
shown
exceptional
potential
as
carriers,
enabling
safe
controlled
local
delivery.
The
challenges
translate
MOF
therapies
clinical
use
require
not
only
validate
mechanisms
action
pathways
released
but
also
get
a
deep
understanding
into
rational
design,
it
requires
combination
features
maximize
outcomes.
In
this
perspective,
we
outline
key
criteria
designing
MOFs
delivery
applications
highlight
expanding
range
opportunities
materials
may
offer.
Readers
insights
design
develop
gasotransmitter
with
realistic
clinic
interest.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 2067 - 2079
Published: March 1, 2025
Neurodegenerative
diseases
are
often
linked
to
oxidative
stress
(OS),
which
worsen
neuroinflammation
and
cause
neuronal
damage.
Managing
OS
with
gasotransmitters
such
as
hydrogen
sulphide
(H2S)
is
a
promising
therapeutic
approach
protecting
brain
cells
from
AP39,
mitochondria-targeted
H2S
donor,
has
shown
neuroprotective
potential
by
reducing
improving
mitochondrial
function.
However,
its
clinical
application
limited
due
poor
stability
rapid
release,
necessitating
drug
delivery
system
enhance
efficacy.
This
study
aimed
develop
novel
AP39-loaded
liposomal
formulation
provide
controlled
facilitate
AP39
permeation
across
the
blood-brain
barrier
(BBB),
assess
functional
effects
in
mitigating
preserving
unilamellar
liposomes
were
prepared
via
ethanol
injection
characterised
for
size,
polydispersity,
zeta
potential.
Entrapment
efficiency
was
determined
using
HPLC,
while
cytotoxicity
assessed
human
vein
endothelial
(HUVEC)
neuroblastoma
(SHSY5Y)
cells.
Liposomal
permeability,
release
kinetics,
cellular
uptake
evaluated
microvasculature
BBB
model.
Mitochondrial
function
under
Seahorse
XFe24
Analyzer.
had
an
average
size
of
135.92
±
10.05
nm,
17.35
3.40
mV,
entrapment
84.48%
4.7.
Cytotoxicity
studies
showed
no
adverse
after
4
h.
Cellular
encapsulated
significantly
higher
(7.13
0.28
µg)
than
free
form
(5.8
0.31
µg).
The
model
demonstrated
sustained
(7.28
µg/mL
vs
6.44
AP39).
assays
confirmed
preserved
antioxidant
properties
enhanced
oxygen
consumption.
Our
encapsulating
improves
stability,
promotes
enhances
permeability
effects.
These
findings
indicate
that
suitable
further
investigate
treatment
neurodegenerative
diseases.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7014 - 7014
Published: June 27, 2024
Among
the
various
drug
discovery
methods,
a
very
promising
modern
approach
consists
in
designing
multi-target-directed
ligands
(MTDLs)
able
to
modulate
multiple
targets
of
interest,
including
pathways
where
hydrogen
sulfide
(H2S)
is
involved.
By
incorporating
an
H2S
donor
moiety
into
native
drug,
researchers
have
been
simultaneously
target
therapeutic
pathways,
resulting
improved
treatment
outcomes.
This
review
gives
reader
some
pills
successful
multi-target
H2S-donating
molecules
as
worthwhile
tools
combat
multifactorial
nature
complex
disorders,
such
inflammatory-based
diseases
and
cancer,
well
cardiovascular,
metabolic,
neurodegenerative
disorders.
The Astrophysical Journal Letters,
Journal Year:
2024,
Volume and Issue:
965(2), P. L26 - L26
Published: April 1, 2024
Abstract
We
present
the
first
detection
in
space
of
thionylimide
(HNSO)
toward
Galactic
center
molecular
cloud
G
+
0.693-0.027,
thanks
to
superb
sensitivity
an
ultradeep
line
survey
carried
out
with
Yebes
40
m
and
IRAM
30
telescopes.
This
molecule
is
species
detected
interstellar
medium
containing,
simultaneously,
N,
S,
O.
have
identified
numerous
K
a
=
0,
1,
2
transitions
belonging
HNSO
covering
from
J
up
=10,
including
several
completely
unblended
features.
derive
column
density
N
(8
±
1)×10
13
cm
−2
,
yielding
fractional
abundance
relative
H
∼6
×
10
−10
which
about
∼37
∼4.8
times
less
abundant
than
SO
respectively.
Although
there
are
still
many
unknowns
chemistry
NSO-bearing
molecules,
we
propose
that
likely
formed
through
reaction
NSO
radical
atomic
on
surface
icy
grains,
alternative
routes
also
deserving
exploration.
Finally,
appears
as
promising
link
between
O
chemistry,
its
discovery
paves
route
new
family
molecules
space.
