Patient-derived induced pluripotent stem cells: Tools to advance the understanding and drug discovery in Major Depressive Disorder

Psychiatry Research, Journal Year: 2024, Volume and Issue: 339, P. 116033 - 116033

Published: July 4, 2024

Major Depressive Disorder (MDD) is a pleomorphic disease with substantial patterns of symptoms and severity mensurable deficits in several associated domains. The broad spectrum phenotypes observed patients diagnosed depressive disorders the reflection very complex where clusters biological external factors (e.g., response/processing life events, intrapsychic factors) converge mediate pathogenesis, clinical presentation/phenotypes trajectory. Patient-derived induced pluripotent stem cells (iPSCs) enable their differentiation into specialised cell types central nervous system to explore pathophysiological substrates MDD. These models may complement animal advance drug discovery identify therapeutic approaches, such as therapy, repurposing, elucidation metabolism, toxicity, mechanisms action at molecular/cellular level, pave way for precision psychiatry. Despite remarkable scientific progress made over last few decades, still poorly understood, incidence prevalence continue increase, more research needed meet demands. This review aims summarise provide critical overview conducted thus far using patient-derived iPSCs modelling psychiatric disorders, particular emphasis on

Language: Английский

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Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions

Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 40(1)

Published: Dec. 13, 2024

Language: Английский

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No Brain is an Island: Commentary on Billot and Kiran

Brain and Language, Journal Year: 2024, Volume and Issue: 258, P. 105483 - 105483

Published: Oct. 31, 2024

Language: Английский

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