Diabetes is the missing link between cardiometabolic index and gallstones: a large cross-sectional study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 22, 2025

The cardiometabolic index (CMI), which integrates individual lipid and visceral fat parameters, represents a superior new predictive tool for cardiovascular metabolic disorders, but its value gallstones (GS) is unclear. Therefore, the present study used this vacancy to explore relationship between CMI levels GS in US adults, assess mediating role of diabetes mellitus pathogenesis both, provide clinical ideas early prevention screening patients with mellitus. This survey extracted information from National Health Nutrition Examination Survey (NHANES) 2017–2020 vintage cycle. Cross-sectional analyses variety statistical techniques were analyze correlation GS, including logistic regression, propensity score matching, subject work curves, restricted cubic spline (RCS). Furthermore, mediation analysis was investigate whether what extent mediated effect on GS. After 3,395 participants, significant positive observed elevated increased prevalence In fully corrected model (Model 4), exhibited 23% increase every incremental unit rise logarithmically transformed CM. Mediation showed that largely association ratio 15.1%. Higher are closely linked greater occurrence plays key both. Addressing dyslipidemia while not neglecting blood glucose levels, co-management two may be proven way reduce risk.

Language: Английский

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Cardiovascular Risk Prediction in Hemodialysis Patients using the Triglyceride-Glucose Index: A Multicenter Prospective Cohort Study

Clinical Kidney Journal, Journal Year: 2025, Volume and Issue: 18(3)

Published: Jan. 20, 2025

Triglyceride-glucose (TyG) index has recently been established as an indicator of insulin resistance and predictive value for cardiovascular (CV) disease. However, the clinical significance TyG in patients undergoing hemodialysis remains unknown. We prospectively enrolled 759 maintenance hemodialysis. The participants were divided into tertiles based on their baseline index. Echocardiographic parameters, vascular calcification scores, several plasma biomarkers obtained compared using was positively correlated with levels circulating pathologic markers, endostatin (ρ = 0.134, P .025) adhesion protein-1 0.130, .012), but not score. any echocardiographic parameters. Patients tertile 3 showed highest cumulative event rates CV cardiac events (P < .001 .001, respectively). In multivariable Cox regression analysis, had a significantly increased risk to those 1 [adjusted hazard ratio (HR): 1.89, 95% confidence interval (CI): 1.08-3.30, adjusted HR: 2.01, CI: 1.05-3.82, respectively]. A standard deviation increase also associated higher risks events. pathology markers adverse outcomes Our study suggests that potential assist clinicians identifying high patients.

Language: Английский

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Association Between Two Novel Visceral Obesity Indicators and Heart Failure Among US Adults: A Cross-Sectional Study

Metabolic Syndrome and Related Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Background: This study aimed to explore the association of cardiometabolic index (CMI), CMI-age, visceral adiposity (VAI), and VAI-age with heart failure (HF) compare those indicators for early identification HF.

Language: Английский

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Association of cardiometabolic index and new-onset stroke in middle-aged and elderly Chinese: a national prospective cohort study

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

The Cardiometabolic Index (CMI), a novel metabolic marker, has been associated with various diseases in previous studies. However, its relationship stroke risk remains underexplored. This study investigates the potential correlation between CMI and among Chinese adults aged 45 older. In China Health Retirement Longitudinal Study (CHARLS), participants were categorized into four groups based on quartiles. primary outcome was incidence of new strokes during follow-up period. A Cox proportional hazards model used to analyze elderly. Kaplan–Meier survival analysis compared rates across levels, restricted cubic splines (RCS) assessed non-linear relationships stroke. Subgroup analyses verified robustness these findings. included 6620 patients (45% male), 417 cases reported over an average seven years. Multivariate indicated significant association increased higher [HR, 1.132 (1.021–1.273), P = 0.003]. RCS revealed nonlinear increase rising levels (P for nonlinearity 0.006). No interactions detected selected subgroups (all values interaction > 0.05). significantly correlates elderly population, suggesting utility early stratification.

Language: Английский

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Cardiometabolic index predicts cardiovascular events in aging population: a machine learning-based risk prediction framework from a large-scale longitudinal study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

While the Cardiometabolic Index (CMI) serves as a novel marker for assessing adipose tissue distribution and metabolic function, its prognostic utility cardiovascular disease (CVD) events remains incompletely understood. This investigation sought to elucidate predictive capabilities of CMI outcomes explore underlying mechanistic pathways establish comprehensive risk prediction framework. The study encompassed 7,822 individuals from national health retirement longitudinal cohort, with participants stratified by quartiles. Following baseline characteristic comparisons CVD incidence rate calculations, we implemented multiple Cox regression models assess CMI's capabilities. For nomogram construction, utilized an ensemble machine learning framework, combining Boruta algorithm-based feature selection Random Forest (RF) XGBoost analyses determine key parameters. Throughout median follow-up duration 84 months, documented 1,500 incident cases, comprising 1,148 cardiac 488 cerebrovascular events. demonstrated positive gradient across ascending Multivariate analysis, adjusting potential confounders, confirmed significant association between risk. Notably, mediation revealed that hypertension glycated hemoglobin (HbA1c) potentially serve intermediaries in CMI-CVD relationship. Sex-stratified suggested differential patterns gender subgroups. Given robust consistent capability stroke outcomes, developed learning-derived incorporating five predictors: age, CMI, status, high-sensitivity C-reactive protein (hsCRP) renal function (measured serum creatinine). strong discriminative ability, achieving areas under receiver operating curve (AUC) 0.76 (95% CI: 0.56-0.97) 0.74 0.66-0.81) 2-year 6-year prediction, respectively. Our findings predictor aging population, relationship partially mediated through insulin resistance pathways. validated nomogram, using data substantial elderly incorporates enable preclinical stratification, supporting timely preventive strategies.

Language: Английский

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Association between cardiometabolic index and congestive heart failure among US adults: a cross-sectional study

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 10, 2024

The risk of congestive heart failure (CHF) is significantly affected by obesity. However, data on the association between visceral obesity and CHF remain limited. We explored relationship cardiometabolic index (CMI).

Language: Английский

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Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 29, 2024

It is crucial to identify biomarkers that influence the aging process and associated health risks, given growing severity of global population issue. The objectives our research were evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at increased risk accelerated biological assess its use in guiding preventive strategies aging-related risks.

Language: Английский

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Association between the triglyceride–glucose index and left ventricular myocardial work indices in patients with coronary artery disease

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

Triglyceride-glucose (TyG) index, as an effective surrogate marker of insulin resistance, has shown predictive value in the risk heart failure patients with coronary artery disease (CAD). This study aims to investigate correlation between TyG index and myocardial work measurements CAD, explore its role detecting early subclinical cardiac dysfunction.

Language: Английский

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Correlation between cardiometabolic index and female infertility: a cross-sectional analysis

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 14, 2024

Obesity and adverse lipid profile leads to female infertility. The cardiometabolic index (CMI) is a promising indicator for predicting obesity-related diseases. correlation between CMI infertility merits further investigation. data this study were acquired from the 2013–2020 National Health Nutrition Examination Survey (NHANES), with 2333 women enrolled. of each participant was calculated as ratio triglycerides high-density lipoprotein cholesterol multiplied by waist-to-height ratio. Weighted multivariate logistic regression models used assess independent log-transformed Subgroup analyses carried out reliability findings. Interaction tests employed determine whether variables affected interacting log CMI. A total participants aged 18–45 years enrolled, 274 whom infertile. Log group significantly higher than that non-infertility (P < 0.001). After adjustment potential confounders, at an increased risk (OR = 2.411, 95% CI: 1.416–4.112), still consistent in subgroups under 35 Furthermore, restricted cubic spline analysis showed positive non-linear relationship Cardiometabolic levels are positively correlated American females. Our demonstrates predictive capacity

Language: Английский

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Association between cardiometabolic index and female infertility: a cross-sectional analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Background Adverse lipid profile leads to female infertility. The correlation between the cardiometabolic index (CMI) and infertility merits further investigation. Methods data for this study were acquired from 2013–2020 National Health Nutrition Examination Survey (NHANES), with 2333 women enrolled. of each participant was calculated as ratio triglycerides high-density lipoprotein cholesterol multiplied by waist-to-height ratio. Weighted multivariate logistic regression models used assess independent association log-transformed CMI Subgroup analyses carried out reliability findings. Interaction tests employed find if variables affected interacting log CMI. Results A total participants aged 18–45 years enrolled, 274 whom infertile. Log group significantly higher than that non-infertility (P < 0.001). After adjustment potential confounders, more prevalent (OR = 2.411, 95% CI: 1.416–4.112), still consistent in subgroups under 35 Furthermore, restricted cubic spline analysis showed a positive non-linear relationship Conclusions Cardiometabolic levels positively associated increased risk American females. Our demonstrated predictive capacity infertility; nevertheless, additional clarification is required establish direct infertility, which will serve foundation future efforts prevent

Language: Английский

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