Study on the predictive value of laboratory inflammatory markers and blood count-derived inflammatory markers for disease severity and prognosis in COVID-19 patients: a study conducted at a university-affiliated infectious disease hospital

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Oct. 24, 2024

Background Since the outbreak of coronavirus disease 2019 (COVID-19), studies have found correlations between blood cell count-derived inflammatory markers (BCDIMs) and severity prognosis in COVID-19 patients. However, there is currently a lack systematic comparisons procalcitonin (PCT), C-reactive protein (CRP), protein-to-albumin ratio (CAR) BCDIMs for assessing

Language: Английский

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A nomogram for predicting unfavorable outcomes of antituberculosis treatment among individuals with AIDS combined with pulmonary tuberculosis in China

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 29, 2025

Background Acquired Immune Deficiency Syndrome (AIDS) combined with tuberculosis (TB) is one of the key factors affecting global TB control, and timely effective treatment essential to improve prognosis in this population. However, data from WHO have shown that patients AIDS a lower anti-TB success rate than HIV-negative individuals do, which may lead an increased incidence relapse drug resistance. Therefore, exploring risk outcome developing relevant predictive models will help clinicians rapidly identify at greater failure, highly valuable for clinical management. Methods We conducted retrospective cohort study including inpatients pulmonary (PTB) who were treated Beijing Youan Hospital between January 2020 2024. The baseline laboratory test all enrolled collected electronic medical records system. randomly divided participants into training set validation ratio 2:1 established LASSO Cox model on basis treatment. selected prognostic then used construct final model, was visualized using nomogram. receiver operating characteristic (ROC) curves, concordance index (C-index), calibration curves evaluate discrimination ability consistency respectively. Decision curve analysis (DCA) assess applicability models. Patients subsequently stratified according optimal cutoff value by X-tile software better decision-making clinicians. Results A total 203 PTB study, 141 (69.5%) 62 (30.5%) unfavorable outcome. results regression revealed CRP/albumin (CAR), extrapulmonary disseminated tuberculosis, other infectious diseases, cavitation independent outcomes PTB, whereas CD4 + T-cell counts protective factor patient outcomes. five variables further establish AUC (0.760 0.811 set) C-index (0.765 0.768 showed we constructed had good ability. indicated high predictions actual observations both set. DCA nomogram applicability. risk-stratified score, three groups: low (total points <358), medium (358 ≤ <373), ≥373). Clinicians should focus whose score more 358 points. Conclusion identified failure PTB. Our performed satisfactorily can be screening management high-risk patients.

Language: Английский

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Non-linear Association of CAR with all-Cause and Cardiovascular Mortality in Coronary Heart Disease: A Retrospective Cohort Study from NHANES

Clinical and Applied Thrombosis/Hemostasis, Journal Year: 2024, Volume and Issue: 30

Published: Jan. 1, 2024

Objective To investigate the relationship between C-reactive protein and albumin ratios (CAR) all-cause cardiovascular disease(CVD)-specific mortality in individuals with coronary heart disease(CHD). Methods The data from 1895 patients were extracted National Health Nutrition Examination Survey (NHANES) database 1999–2010. We used weighted COX regression analyses to explore association CAR, all-cause, CVD-specific mortality. Restricted cubic spline(RCS) models threshold effects analysis analyze nonlinear relationships. Subgroup also performed these relationships further. Results During a mean follow-up of 115.78 months, 61.48% deaths occurred, 21.85% due CVD. After adjusting for potential confounders, each 1-unit increase CAR was associated 65% 67% RCS model revealed non-linear risk CHD (all P < 0.001). Threshold identified inflection points (0.04, 0.001) (0.05, = 0.0024). interaction tests found sex, smoking diabetes influenced HF its 0.05). Conclusion There CVD CHD, higher hazard ratio before point. Sex, smoking, diabetes, might have an effect on associations death risks.

Language: Английский

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Statin use, albuminuria, and mortality risk: Re-evaluating C-reactive protein to albumin ratio in hypertensive patients based on NHANES data

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(8), P. 2016 - 2017

Published: April 14, 2024

Language: Английский

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Letter to the editor: The relationship between C-reactive protein/albumin ratio and mortality in hypertensive patients: A national cohort study

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(12), P. 2846 - 2847

Published: Aug. 3, 2024

Language: Английский

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