Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2021, Volume and Issue: 1876(2), P. 188612 - 188612
Published: Aug. 12, 2021
Language: Английский
Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)
Published: May 27, 2020
Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate patients with early-stage localized gastric more than 60%, whereas that distant metastasis less 5%. Surgical resection best option for cancer, while chemotherapy mainly used in middle advanced stages this disease, despite frequently reported treatment failure due to resistance. Therefore, there an unmet medical need identifying new biomarkers early diagnosis proper management patients, achieve response treatment. Long non-coding RNAs (lncRNAs) body fluids have attracted widespread attention as screening, diagnosis, treatment, prognosis, responses drugs high specificity sensitivity. In present review, we focus on clinical potential lncRNAs liquid biopsies prognosis cancer. We also comprehensively discuss roles their molecular mechanisms chemoresistance well therapeutic targets precision medicine.
Language: Английский
Citations
264
Pharmacological Research, Journal Year: 2021, Volume and Issue: 167, P. 105575 - 105575
Published: March 24, 2021
Language: Английский
Citations
118
Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 131, P. 110676 - 110676
Published: Aug. 25, 2020
Chemoresistance is a central cause for the tumor management failure. Cancer cells disrupt redox homeostasis through reactive oxygen species (ROS) regulatory mechanisms, leading to progression and chemoresistance. The transcription factor nuclear erythroid 2-related 2 (NRF2) master regulator of neutralizing cellular ROS restoring balance. Understanding role NRF2 in ROS-mediated chemoresistance can be helpful development chemotherapy strategies with better efficiency. In this review, we sum up roles classical agents including cisplatin, 5-fluorouracil, gemcitabine, oxaliplatin, paclitaxel, doxorubicin, how overcome by targeting NRF2. Finally, propose that might promising strategy resist ROS-driven acquire efficacy cancer treatment.
Language: Английский
Citations
137
Seminars in Cancer Biology, Journal Year: 2020, Volume and Issue: 83, P. 303 - 318
Published: Nov. 15, 2020
Language: Английский
Citations
96
Drug Discovery Today, Journal Year: 2022, Volume and Issue: 27(8), P. 2181 - 2198
Published: May 16, 2022
Language: Английский
Citations
56
Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)
Published: Jan. 26, 2022
Abstract Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen species (ROS), is an emerging hallmark cancer. Tumorigenesis and development driven ROS require aberrant redox homeostasis, that activates onco-signaling avoids ROS-induced programmed death orchestrating antioxidant systems. These processes are revealed to closely associate with noncoding RNAs (ncRNAs). On basis available evidence, ncRNAs have been widely identified as multifarious modulators involvement several key sensing pathways, such NF-κB Nrf2 signaling, therefore potentially becoming effective targets for cancer therapy. Furthermore, vast majority property easy detected in fluid samples (e.g., blood urine) facilitate clinicians monitor indicating a novel method diagnosis. Herein, focusing on carcinoma initiation, metastasis chemoradiotherapy resistance, we aimed discuss ncRNAs-ROS network involved progression, potential clinical application biomarkers therapeutic targets.
Language: Английский
Citations
40
Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 184, P. 53 - 65
Published: March 31, 2022
Language: Английский
Citations
40
Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)
Published: Jan. 24, 2023
Abstract Despite significant progress in clinical management, drug resistance remains a major obstacle. Recent research based on protein degradation to restrain has attracted wide attention, and several therapeutic strategies such as inhibition of proteasome with bortezomib proteolysis-targeting chimeric have been developed. Compared intervention at the transcriptional level, targeting process seems be more rapid direct strategy. Proteasomal proteolysis lysosomal are most critical quality control systems responsible for proteins or organelles. Although proteasomal inhibitors (e.g., chloroquine) achieved certain improvements some application scenarios, their routine practice is still long way off, which due lack precise capabilities inevitable side effects. In-depth studies regulatory mechanism regulators, including E3 ubiquitin ligases, deubiquitylating enzymes (DUBs), chaperones, expected provide clues developing reducing Here, we discuss underlying mechanisms regulating efflux, metabolism, DNA repair, target alteration, downstream bypass signaling, sustaining stemness, tumor microenvironment remodeling delineate functional roles resistance. We also highlight specific DUBs, discussing possible modulating cancer A systematic summary molecular basis by regulates will help facilitate development appropriate strategies.
Language: Английский
Citations
30
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression poor prognosis. This process is primarily driven by EMT, which has been the focus recent studies highlighting role long non-coding RNAs (lncRNAs) as crucial regulators EMT. However, mechanisms lncRNAs influence invasive multifaceted, extending beyond EMT regulation alone. review aims characterize affecting in cancer. We summarize regulatory roles across multiple molecular pathways highlight their translational potential, considering implications for clinical applications diagnostics therapeutics. focuses on three principal scientific themes. First, we orchestrate various signaling pathways, such TGF-β/Smad, Wnt/β-catenin, Notch, regulate changes associated with thereby enhancing cellular motility invasivenes. Second, effects autophagy ferroptosis discuss exosomal tumor microenvironment behavior neighboring cells promote cell invasion. Third, emphasize RNA modifications (such m6A m5C methylation) stabilizing capacity mediate PC. Lastly, potential these findings, emphasizing inherent challenges using biomarkers therapeutic targets, while proposing prospective research strategies.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2020, Volume and Issue: 8(5), P. 110 - 110
Published: May 5, 2020
Cancer therapy is a growing field, and annually, high number of research performed to develop novel antitumor drugs. Attempts find new drugs continue, since cancer cells are able acquire resistance conventional Natural chemicals can be considered as promising candidates in the field due their multiple-targeting capability. The nobiletin (NOB) ubiquitous flavone isolated from Citrus fruits. NOB has variety pharmacological activities, such antidiabetes, antioxidant, anti-inflammatory, hepatoprotective, neuroprotective. Among them, activity been under attention over recent years. In this review, we comprehensively describe efficacy therapy. induces apoptosis cell cycle arrest cells. It suppress migration invasion via inhibition epithelial-to-mesenchymal transition (EMT) EMT-related factors TGF-β, ZEB, Slug, Snail. Besides, inhibits oncogene STAT3, NF-κB, Akt, PI3K, Wnt, so on. Noteworthy, onco-suppressor microRNA-7 -200b undergo upregulation by These pathways mechanisms discussed review.
Language: Английский
Citations
63