Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

Pharmacological Research, Journal Year: 2021, Volume and Issue: 171, P. 105759 - 105759

Published: July 8, 2021

Language: Английский

---

Roles of circadian clocks in cancer pathogenesis and treatment

Experimental & Molecular Medicine, Journal Year: 2021, Volume and Issue: 53(10), P. 1529 - 1538

Published: Oct. 1, 2021

Abstract Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable organisms to anticipate respond daily changes their environment a timely manner, optimizing temporal physiology behaviors. Dysregulation of circadian by genetic environmental risk factors increases susceptibility multiple diseases, particularly cancers. A growing number studies have revealed dynamic crosstalk between cancer pathways, providing mechanistic insights into the therapeutic utility treatment. This review will discuss roles pathogenesis, highlighting recent advances chronotherapeutic approaches for improved

Language: Английский

---

Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

---

Circadian Rhythms, Disease and Chronotherapy

Journal of Biological Rhythms, Journal Year: 2021, Volume and Issue: 36(6), P. 503 - 531

Published: Sept. 22, 2021

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles sleep/wake, hormone release, metabolism. The adaptive value is evident when internal body daily environmental mismatched, such as in the case shift work jet lag or even mistimed eating, all which associated with physiological disruption disease. Studies animal human models have also unraveled an important role functional circadian modulating cellular organismal responses to cues (ex., food intake, exercise), pathological insults (e.g. virus parasite infections), medical interventions medication). With growing knowledge molecular underlying pathophysiology, it becoming possible target for disease prevention treatment. In this review, we discuss recent advances research potential therapeutic applications take patient into account treating

Language: Английский

---

lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer

Molecular Therapy — Nucleic Acids, Journal Year: 2020, Volume and Issue: 19, P. 974 - 985

Published: Jan. 11, 2020

Drug resistance is the major obstacle of gemcitabine-based chemotherapy for treatment pancreatic ductal adenocarcinoma (PDAC). Many long non-coding RNAs (lncRNAs) are reported to play vital roles in cancer initiation and progression. Here, we report that lncRNA SLC7A11-AS1 involved gemcitabine PDAC. overexpressed PDAC tissues gemcitabine-resistant cell lines. Knockdown weakens stemness potentiates sensitivity resistant cells toward vitro vivo. promotes chemoresistance through reducing intracellular reactive oxygen species (ROS) by stabilizing nuclear factor erythroid-2-related 2 (NRF2), key regulator antioxidant defense. Mechanically, co-localized with β-TRCP1 nucleus. The exon 3 interacts F-box motif β-TRCP1, critical domain recruits SCFβ-TRCP E3 complex. This interaction prevents consequent ubiquitination proteasomal degradation NRF2 Our results demonstrate overexpression can scavenge ROS blocking SCFβ-TRCP-mediated NRF2, leading a low level ROS, which required maintenance stemness. These findings suggest as therapeutic target overcome treatment.

Language: Английский

---

Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways

Journal of Agricultural and Food Chemistry, Journal Year: 2019, Volume and Issue: 67(18), P. 5122 - 5134

Published: April 17, 2019

Neuroinflammation has been intensively demonstrated to be related various neurodegenerative diseases including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer's (AD). A natural polymethoxylated flavone, nobiletin (NOB) reported alleviate oxidative stress, insulin resistance, obesity. In this study, we evaluated the protection effects of NOB on neuroinflammation memory deficit. Three-month mice were administrated with by oral gavage every day for 6 weeks (100 mg/kg/day); subsequently injected intraperitoneally lipopolysaccharide (LPS) 7 days. Results behavioral tests revealed that dramatically ameliorated LPS-triggered deficit regarding synaptic dysfunctions neuronal loss. Also, suppressed microglial activation proinflammatory cytokine secretion, such as COX-2, IL-1β, TNF-α, iNOS. Similarly, upon LPS stimulation, pretreatment diminished secretion cytokines in BV-2 microglia cells exposure via modulating MAPKs, PI3K/AKT, NF-κB signaling pathways. addition, alleviated LPS-amplified redox imbalance, disturbance mitochondrial membrane potential (MMP), dampening expression protein respiration. The present study provides compelling evidence decreased LPS-stimulated impairment through maintaining cellular balance blocking transcriptional pathway, illustrating nutritional compound may serve a approach neuroinflammation-related diseases.

Language: Английский

---

Clocking cancer: the circadian clock as a target in cancer therapy

Oncogene, Journal Year: 2021, Volume and Issue: 40(18), P. 3187 - 3200

Published: April 12, 2021

Language: Английский

---

Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals

Antioxidants, Journal Year: 2021, Volume and Issue: 10(5), P. 743 - 743

Published: May 7, 2021

Colorectal cancer still has a high incidence and mortality rate, according to report from the American Cancer Society. prevalence in patients with inflammatory bowel disease. Oxidative stress, including reactive oxygen species (ROS) lipid peroxidation, been known cause diseases malignant disorders. In particular, nuclear factor erythroid 2-related 2 (Nrf2)/Kelch-like ECH-related protein 1 (KEAP1) pathway is well protect cells oxidative stress inflammation. Nrf2 was first found homolog of hematopoietic transcription p45 NF-E2, member Cap ‘N’ Collar family. KEAP1 as negative regulator that rapidly degrades through proteasome system. A range evidence shown consumption phytochemicals preventive or inhibitory effect on progression proliferation, depending stage colorectal cancer. Therefore, discovery regulating Nrf2/KEAP1 axis verification their efficacy have attracted scientific attention. this review, we summarize role signaling cancer, possible utility respect regulation

Language: Английский

---

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(4)

Published: April 19, 2022

Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor response to standard therapies and therefore unfavorable clinical outcomes. Better understanding of TNBC new therapeutic strategies are urgently needed. ROR nuclear receptors multifunctional transcription factors with important roles in circadian pathways other processes including immunity tumorigenesis. Nobiletin (NOB) natural compound known display anticancer effects, our previous studies showed that NOB activates RORs enhance rhythms promote physiological fitness mice. Here, we identified several cell lines being sensitive NOB, itself or combination. Cell xenograft experiments significantly inhibited proliferation motility vitro vivo. loss- gain-of-function concordant effects the NOB-ROR axis on MDA-MB-231 growth. Mechanistically, found binding elements (RRE) IκBα promoter, strongly p65 translocation. Consistent transcriptomic analysis indicating NF-κB signaling as major altered p65-inducible expression abolished illustrating requisite role suppression mediating anti-TNBC effect NOB. Finally, vivo mouse enhanced antitumor efficacy mammary fat pad implanted TNBC, single agent combination chemotherapy Docetaxel. Together, study highlights an mechanism ROR-NOB via signaling, suggesting novel preventive chemotherapeutic against this devastating disease.

Language: Английский

---

Nobiletin as an inducer of programmed cell death in cancer: a review

APOPTOSIS, Journal Year: 2022, Volume and Issue: 27(5-6), P. 297 - 310

Published: March 21, 2022

Language: Английский

---