Micromachines,
Journal Year:
2022,
Volume and Issue:
13(7), P. 1135 - 1135
Published: July 18, 2022
Laser
additive
manufacturing
(LAM)
of
complex-shaped
metallic
components
offers
great
potential
for
fabricating
customized
endovascular
stents.
In
this
study,
anti-tetrachiral
auxetic
stents
with
negative
Poisson
ratios
(NPR)
were
designed
and
fabricated
via
LAM.
Poisson's
models
different
diameters
circular
node
(DCN)
calculated
using
finite
element
analysis
(FEA).
The
experimental
method
was
conducted
the
LAM-fabricated
to
validate
their
NPR
effect
simulation
results.
results
show
that,
increase
in
DCN
from
0.6
1.5
mm,
varied
-1.03
-1.12,
which
is
line
interrelationship
between
structural
parameters
stents,
mechanical
properties
biocompatibility
demonstrated.
a
0.9
mm
showed
highest
absolute
value
ratio,
combined
good
cytocompatibility.
cytocompatibility
tests
indicate
envisaged
cell
viability
adhesion
vascular
endothelial
on
manufactured
exhibit
superiority
application
stent
implantation
due
high
flexibility
easy
maneuverability
during
deployment
enough
strength
arterial
support.
Science Translational Medicine,
Journal Year:
2024,
Volume and Issue:
16(777)
Published: Dec. 11, 2024
ATP
citrate
lyase
(ACLY),
a
crucial
enzyme
in
de
novo
lipid
synthesis
and
histone
acetylation,
plays
key
role
regulating
vascular
smooth
muscle
cell
(VSMC)
proliferation
survival.
We
found
that
human
coronary
pulmonary
artery
tissues
had
up-regulated
ACLY
expression
during
remodeling
disease
arterial
hypertension.
Pharmacological
genetic
inhibition
of
primary
cultured
VSMCs
isolated
from
the
arteries
patients
with
diseases
distal
hypertension
resulted
reduced
cellular
migration
increased
susceptibility
to
apoptosis.
These
changes
were
linked
diminished
glycolysis,
synthesis,
impairment
general
control
nonrepressed
protein
5
(GCN5)-dependent
acetylation
suppression
transcription
factor
FOXM1.
In
vivo
studies
using
pharmacological
inhibitor
VSMC-specific
Current Obesity Reports,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: March 13, 2025
This
review
aimed
to
highlight
the
known
role
of
histone
deacetylases
(HDACs)
and
lysine
acetyltransferases
(KATs)
in
individuals
with
obesity,
better
understand
HDACs
KATs
enzymes
obesity
related
metabolic
disorders.
Numerous
cellular
activities,
including
DNA
replication,
repair,
cell
cycle
regulation,
RNA
splicing,
signal
transmission,
function,
protein
stability,
transportation,
transcriptional
are
influenced
by
acetylation.
Protein
acetylation
serves
several
purposes,
which
not
only
contribute
development
disorders
linked
but
also
hold
promise
for
therapeutic
approaches.
The
current
study
demonstrates
that
control
details
advancements
made
diseases,
It
contributes
our
understanding
function
mechanism
MS
offers
a
fresh
method
treating
these
diseases.
Micromachines,
Journal Year:
2022,
Volume and Issue:
13(7), P. 1135 - 1135
Published: July 18, 2022
Laser
additive
manufacturing
(LAM)
of
complex-shaped
metallic
components
offers
great
potential
for
fabricating
customized
endovascular
stents.
In
this
study,
anti-tetrachiral
auxetic
stents
with
negative
Poisson
ratios
(NPR)
were
designed
and
fabricated
via
LAM.
Poisson's
models
different
diameters
circular
node
(DCN)
calculated
using
finite
element
analysis
(FEA).
The
experimental
method
was
conducted
the
LAM-fabricated
to
validate
their
NPR
effect
simulation
results.
results
show
that,
increase
in
DCN
from
0.6
1.5
mm,
varied
-1.03
-1.12,
which
is
line
interrelationship
between
structural
parameters
stents,
mechanical
properties
biocompatibility
demonstrated.
a
0.9
mm
showed
highest
absolute
value
ratio,
combined
good
cytocompatibility.
cytocompatibility
tests
indicate
envisaged
cell
viability
adhesion
vascular
endothelial
on
manufactured
exhibit
superiority
application
stent
implantation
due
high
flexibility
easy
maneuverability
during
deployment
enough
strength
arterial
support.
