Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis

Molecular Therapy, Journal Year: 2022, Volume and Issue: 30(10), P. 3118 - 3132

Published: Aug. 2, 2022

Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis, characterized by chronic inflammation caused accumulation plaques in arteries. As our knowledge about microenvironment blood vessel walls deepens, there an opportunity to fine-tune treatments target mechanisms driving atherosclerosis more directly. application non-coding RNAs (ncRNAs) biomarkers or intervention targets increasing. Although these ncRNAs play important role vascular dysfunction, cellular extracellular environments pose a challenge for targeted transmission therapeutic regulation ncRNAs. Specificity, delivery, tolerance have hampered clinical translation ncRNA-based therapeutics. Nanomedicine emerging field uses nanotechnology drug delivery advanced imaging. Recently, nanoscale carriers shown promising results introduced new possibilities nucleic acid particularly atherosclerosis. In this review, we discuss latest developments nanoparticles aid development, miRNA, analyze current challenges ncRNA delivery. particular, highlight emergence various kinds nanotherapeutic approaches based on ncRNAs, which can improve treatment options

Language: Английский

---

Construction of a turn-on fluorescent probe for detecting formaldehyde in biological systems and real food samples

Food Chemistry, Journal Year: 2024, Volume and Issue: 450, P. 139315 - 139315

Published: April 10, 2024

Language: Английский

---

Protective effect and mechanism of ginsenoside Rg2 on atherosclerosis

Journal of Ginseng Research, Journal Year: 2022, Volume and Issue: 47(2), P. 237 - 245

Published: Aug. 6, 2022

Ginsenoside Rg2 (Rg2) has a variety of pharmacological activities and provides benefits during inflammation, cancer, other diseases. However, there are no reports about the relationship between atherosclerosis.We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to detect cell viability in vascular smooth muscle cells (VSMCs) human umbilical vein endothelial (HUVECs). The expression inflammatory factors HUVECs phenotypic transformation-related marker VSMCs were detected at mRNA levels. Western blot method was inflammation pathways transformation protein rat carotid balloon injury model performed explore effect on vivo.Rg2 decreased induced by lipopolysaccharide HUVECs-without affecting viability. These events depend blocking regulation NF-κB p-ERK signaling pathway. In VSMCs, can inhibit proliferation, migration, platelet derived growth factor-BB (PDGF-BB)-which may contribute its anti-atherosclerotic role. rats with injury, reduce intimal proliferation after regulate pathway response, also suppress VSMCs.These results suggest that exert cellular level animal level, which more sufficient basis for ginseng as functional dietary regulator.

Language: Английский

---

miR-564: A potential regulator of vascular smooth muscle cells and therapeutic target for aortic dissection

Journal of Molecular and Cellular Cardiology, Journal Year: 2022, Volume and Issue: 170, P. 100 - 114

Published: June 18, 2022

Language: Английский

---

The lncRNA Punisher Regulates Apoptosis and Mitochondrial Homeostasis of Vascular Smooth Muscle Cells via Targeting miR-664a-5p and OPA1

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 21

Published: May 25, 2022

Long noncoding RNAs (lncRNAs) are important regulators of various cellular functions. Recent studies have shown that a novel lncRNA termed Punisher is highly expressed in cardiovascular progenitors and has potential role diseases. However, its role, especially molecular mechanism, unclear. In our present study, we observed was obviously downregulated atherosclerotic plaques. Further research proved it can suppress the apoptosis VSMCs potentially contributing to progression atherosclerosis. Intriguingly, revealed regulate mitochondria fission as well mitochondrial functions induced by hydrogen peroxide (H2O2) VSMCs. Mechanistically, further serve ceRNA which directly binds miR-664a-5p consequently regulates target OPA1, finally contributes biological function Particularly, overexpression distinctly suppressed neointima formation VSMC vivo. Encouragingly, these results were accordance with findings obtained clinical evaluation patients Our data provides significant relationship among homeostasis, apoptosis, And could targets diagnosis treatment

Language: Английский

---

Effects of formaldehyde on YAP and NF-κB signaling pathways in mammalian cells

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102155 - 102155

Published: Feb. 1, 2025

Language: Английский

---

Temporal distribution of environmental pollutants in high-occupancy buildings transitional spaces and exposure risk assessment for different flow paths

Building and Environment, Journal Year: 2025, Volume and Issue: unknown, P. 112840 - 112840

Published: March 1, 2025

Language: Английский

---

Formaldehyde Sensing Using Tapered U-Shape Plastic Optical Fiber Coated With Zinc Oxide Nanorods

IEEE Access, Journal Year: 2022, Volume and Issue: 10, P. 91445 - 91451

Published: Jan. 1, 2022

Continuous exposure to formaldehyde may cause injury the central nervous, respiratory, blood, and immunological systems. Tapered U-shape plastic optical fiber (POF) coated with zinc oxide nanorods was evaluated at wavelength of 645 nm for vapor sensing within a concentration range from 5% 20%. The tapered POF 500 μm waist diameter prepared using chemical etching technique. Zinc were synthesized hydrothermal method growth 12 hours on POF. proposed sensor exhibited good response ranging 20% sensitivity linearity measured be 0.00543V/% 98.58%, respectively. Excellent measurement stability observed when concentrations above are maintain over 600 second period. Highest difference voltage produced by 0.0958V due more scattering effect ZnO concentration. This might also used detect air pollution not just vapor, but other dangerous or poisonous vapors gases.

Language: Английский

---

Identification of long non-coding RNA in formaldehyde-induced cardiac dysplasia in rats

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 174, P. 113653 - 113653

Published: Feb. 8, 2023

Language: Английский

---

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

Biomolecules, Journal Year: 2022, Volume and Issue: 12(4), P. 513 - 513

Published: March 28, 2022

Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures assessing their correlation effects on individual health is defined as the exposome, which interacts our unique characteristics such genetics, physiology, epigenetics. Epigenetics investigates modifications expression genes that do not depend underlying DNA sequence. Some studies have confirmed factors may promote disease individuals or subsequent progeny through epigenetic alterations. Variations machinery cause spectrum different disorders since these mechanisms are more sensitive to environment than genome, due inherent reversible nature landscape. Several mechanisms, (e.g., methylation), histones, noncoding RNAs can change genome under exogenous influence. Notably, long processes has been well explored context exposome-induced tumorigenesis. In present review, scope provide relevant evidence indicating alterations mediate those detrimental caused by exposure toxicants, focusing mainly multi-step regulation diverse subtypes.

Language: Английский

---