Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 189, P. 136 - 153

Published: July 31, 2022

Language: Английский

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The involvement of ROS-regulated programmed cell death in hepatocellular carcinoma

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 197, P. 104361 - 104361

Published: April 16, 2024

Language: Английский

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Cordyceps militaris polysaccharide alleviates ovalbumin-induced allergic asthma through the Nrf2/HO-1 and NF-κB signaling pathways and regulates the gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 238, P. 124333 - 124333

Published: April 6, 2023

Language: Английский

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Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 10, 2023

Liver fibrosis and hepatocellular carcinogenesis secondary to liver are serious diseases with no effective treatments. Mori fructus aqueous extracts (MFAEs) have served as successful treatments for many types of injury including although the molecular mechanisms unknown at present. To investigate effect MFAEs in alleviating acute chronic tried decipher underlying mechanism. Mice were divided into 5 groups (n = 8) (groups: control, 0.3% CCl4, bifendate (BD), 100 200 mg/kg MFAEs, 7 d) 10% BD, 4 weeks) study. Each mouse was injected intraperitoneally 10 µL/g corn oil containing CCl4 expect control group. HepG2 cells used vitro Eighteen communal components identified by UPLC-LTQ-Orbitrap-MS. We utilized a model using administration effectively blocked significantly inhibited inflammation liver. activated nuclear factor erythroid derived 2 like 2/heme oxygenase 1 (Nrf2/HO-1) pathway promoted synthesis antioxidants glutathione (GSH), superoxidedismutase (SOD) peroxidase (GSH-Px) that resulted reduced levels CCl4-induced oxidative stress molecules reactive oxygen species. These administered mice also ferroptosis regulating expression Acyl-CoA synthetase long chain family member (ACSL4), solute carrier 11 (SLC7A11) (GPX4), thus reducing occurrence fibrosis. Both vivo tests indicated mechanism protection against linked activation Nrf2 signaling. effects addition specific inhibitor. stress, activating signal provided significant protective

Language: Английский

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Targeting Hippo pathway: A novel strategy for Helicobacter pylori-induced gastric cancer treatment

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114549 - 114549

Published: March 21, 2023

The Hippo pathway plays an important role in cell proliferation, apoptosis, and differentiation; it is a crucial regulatory organ development tumor growth. Infection with Helicobacter pylori (H. pylori) increases the risk of developing gastric cancer. In recent years, significant progress has been made understanding mechanisms by which H. infection promotes progression cancer via pathway. Exploring molecules may yield new diagnostic therapeutic targets for pylori-induced current article reviews composition mechanism pathway, as well research occurrence pylori-related cancer, order to provide broader perspective study prevention

Language: Английский

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YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Skeletal muscles and bones are closely connected anatomically functionally. Age-related degeneration in these tissues is associated with physical disability the elderly significantly impacts their quality of life. Understanding mechanisms age-related musculoskeletal tissue crucial for identifying molecular targets therapeutic interventions skeletal muscle atrophy osteoporosis. The Hippo pathway a recently identified signaling that plays critical roles development, homeostasis, regeneration. Yes-associated protein (YAP) transcriptional coactivator PDZ-binding motif (TAZ) key downstream effectors mammalian pathway. This review highlights fundamental YAP TAZ homeostatic maintenance regeneration bones. YAP/TAZ play significant role stem cell function by relaying various environmental signals to cells. osteoporosis related dysfunction or senescence triggered dysregulation resulting from reduced mechanosensing mitochondrial In contrast, activation can suppress may be used as basis development potential strategies. Thus, targeting holds alleviating bone improving life elderly.

Language: Английский

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β‐1,4‐Galactosyltransferase 1 protects against cerebral ischemia injury in mice by suppressing ferroptosis via the TAZ/Nrf2/HO‐1 signaling pathway

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(9)

Published: Sept. 1, 2024

Abstract Background Ischemic stroke leads a primary cause of mortality in human diseases, with high disability rate worldwide. This study aims to investigate the function β‐1,4‐galactosyltransferase 1 (B4galt1) mouse brain ischemia/reperfusion (I/R) injury. Methods Recombinant B4galt1 (rh‐B4galt1) was intranasally administered mice model middle cerebral artery occlusion (MCAO)/reperfusion. In this study, impact rh‐B4galt1 on injury assessed using multiple methods, including neurological status scale, 2,3,5‐triphenyltetrazolium chloride (TTC), Nissl and TUNEL staining. utilized laser speckle Doppler flowmeter monitor blood flow. Western blotting performed assess protein expression levels, fluorescence‐labeled dihydroethidium method determine superoxide anion generation. Assay kits were used for measurement iron, malondialdehyde (MDA) glutathione (GSH) levels. Results We demonstrated that markedly improved function, reduced infarct volume preserved completeness blood–brain barrier (BBB) preventing damage. These findings further illustrated alleviated oxidative stress, lipid peroxidation, as well iron deposition induced by I/R. The vital role ferroptosis proved Furthermore, could increase levels TAZ, Nrf2 HO‐1 after And TAZ‐siRNA ML385 reversed neuroprotective effects rh‐B4galt1. Conclusions results indicated implements modulating ferroptosis, primarily via upregulating TAZ/Nrf2/HO‐1 pathway. Thus, be seen promising novel objective ischemic therapy.

Language: Английский

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Glyphosate-Based Herbicide Stress During Pregnancy Impairs Intestinal Development in Newborn Piglets by Modifying DNA Methylation

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Glyphosate-based herbicide (GBH), a feed contaminant, has been proven to impair the growth and development of humans animals. Previous research revealed that maternal toxin exposure during pregnancy could cause permanent fetal changes by epigenetic modulation. However, there was insufficient evidence involvement DNA methylation in GBH exposure-induced intestinal health offspring. Here, we established pregnant sow models investigate effects on newborn piglets. The results showed gestational compromises function piglets as well decreases mRNA expression Dnmt1 Dnmt3b jejunum. Further RRBS analysis genomic hypomethylation jejunum, differentially methylated regions were enriched pathways food digestion related GO terms. Additionally, integrative methylome transcriptome identified 23 genes showing inverse correlations indicated underlying injury mechanisms upon GBH. These findings provide new insights fundamental knowledge into possible offspring induced pregnancy, which drives manufacturers develop low-toxicity ensure safety human health.

Language: Английский

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The active roles of Rhodotorula mucilaginosa ZTHY2 in regulating antioxidant capacity and immune function of Leizhou black ducks

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Previous studies in mice have demonstrated that Rhodotorula mucilaginosa ZTHY2 can promote animal growth, enhance antioxidant and immune functions, regulate intestinal flora our laboratory. This study focuses on the Leizhou black duck, a local breed Zhanjiang, to evaluate effects of its capacity, function. A total 150 1-day-old male ducks, similar size healthy, were selected for this randomly assigned five treatment groups. Each group contained three replicates with ten birds each. The control (Control) was given standard basal diet, while RM received diet supplemented at concentrations 2 × 10 7 (RM1), 8 (RM2), or 9 (RM3) CFU/kg, respectively. LA CFU/kg Lactobacillus acidophilus addition diet. feeding trial lasted 42 days. analysis revealed significant improvements average body weight RM2 RM3 groups, which significantly higher than ( p < 0.05 0.01). Treatment induced dose-dependent elevation superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), SOD activities, reduction malondialdehyde (MDA) content serum levels complement components C3 C4, immunoglobulin IgG, cytokines IFN- γ , IL-2, IL-4, IL-6, TNF- α increased ducks treated 42-days post-treatment, therapeutic effect becoming more pronounced as duration experiment prolonged. greatest impact observed dosage ZTHY2. Moreover, modulated mRNA expression profiles these thymus, spleen, bursa, thereby sustaining balance dynamics. In summary, supplementation had been found most effectively growth performance by optimizing their function capacity.

Language: Английский

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Regulation of Postoperative Cognitive Dysfunction by Glutathione Under Various Pathways: A Narrative Review

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(2)

Published: Feb. 1, 2025

Postoperative cognitive dysfunction (POCD) is a common neurological complication after surgery and general anesthesia, the incidence increases with age. Will have negative impact on patients, family society. At present, neuroinflammation oxidative stress are main recognized mechanisms. Glutathione (GSH) powerful reducing agent may be related to POCD. Using medical search engines such as PubMed, Web of Science, we analyzed articles topics as: POCD, GSH, microglia, astrocyte, oligodendrocyte, ferroptosis, BDNF, Neuroinflammation, stress. The above searched in databases using Boolean operations. We included original articles, reviews other article types books. According reviewed literature, GSH treatment for Specific targeted therapies POCD still sparse, therefore, implementation preventive strategies appears remain optimal attitude. Further research needed better understanding

Language: Английский

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