International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139194 - 139194
Published: Dec. 1, 2024
Language: Английский
MedComm, Journal Year: 2025, Volume and Issue: 6(3)
Published: March 1, 2025
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally, predominantly associated with chronic hepatitis B virus (HBV) and C (HCV) infections. These infections drive persistent liver inflammation, culminating in cellular dysregulation, fibrosis, cancer. Despite advancements targeted therapies, drug resistance the lack reliable biomarkers for patient stratification still terribly hinder treatment viral HCC. To this end, review delves into intricate mechanisms underlying malignant transformation to HCC, including integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, immune escape, abnormal signaling pathways, highlighting their complex interactions synergies. Cutting-edge preclinical clinical HCC management, lifestyle immunotherapies, gene-based approaches, innovative treatments, are further investigated, particular priority given therapeutic potential future applications overcoming current limitations. By synthesizing recent scientific insights, aims deepen understanding pathogenesis context hepatitis, paving way novel targets personalized strategies, ultimately improving outcomes.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216303 - 216303
Published: Nov. 10, 2024
Language: Английский
Citations
4
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317454 - e0317454
Published: Jan. 17, 2025
Primary hepatocellular carcinoma (PHC) is the sixth most common cancer and third leading cause of death worldwide. Hepatocellular (HCC) accounts for 75%-85% PHC. LARP3 aberrantly expressed in multiple cancers. We found that it significantly highly liver tissues HCC patients, but exact role specific mechanism this abnormal expression are not yet clear. In study, through bioinformatics analysis, we concluded associated with a poor prognosis patients HCC. Through cellular experiments such as gene editing phenotypic functions, promotes occurrence development inhibits apoptosis. Finally, biological means RNA sequencing, flow cytometry, western blotting, construction subcutaneous tumorigenesis model nude mice, inhibition apoptosis by related to negatively regulating ROS level inhibiting PI3K/c-Fos/apoptosis axis. This study will provide potential targets treatment
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal forms liver cancer, contributing significantly to global cancer-related mortality. Conventional treatments, including surgical resection, transplantation, systemic therapies such as multikinase inhibitors immune checkpoint inhibitors, often face limitations toxicity drug resistance, emphasizing urgent need for more effective therapeutic strategies. In this study, we developed a galactose-functionalized dendrimer (Gal24) conjugated with natural flavonoid, silibinin, (Gal24-Sil), HCC therapy. our previous Gal24 target hepatocytes in vivo. Here, further demonstrated that conjugation silibinin platform enhanced its solubility efficacy. vitro studies Gal24-Sil conjugates improved anticancer efficacy HepG2 Hep3B cancer cells. The conjugate induced an inflammatory response reactive oxygen species (ROS) generation, triggering cellular apoptosis necrosis. Furthermore, effectively reduced cell proliferation by promoting mitochondrial membrane potential (MMP) depolarization inducing DNA damage. Our findings demonstrate promising nanoplatform therapy, offering over free Silibinin. This study highlights broader applicability addressing various diseases.
Language: Английский
Citations
0
Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 964 - 964
Published: Aug. 8, 2024
This review delves into the advantages of exosomes as novel antioxidants in animal nutrition and their potential for regulating oxidative stress. Although traditional nutritional approaches promote stress defense systems mammalian animals, several issues remain to be solved, such low bioavailability, targeted tissue efficiency, high-dose by-effect. As an important candidate offering regulation opportunities concerned with cellular communication, disease prevention, physiology multiple biological systems, mediating redox status has not been well described. A previously reported relationship between system circulating suggested a fundamental both regulator biomarker system. Herein, we effects on animals application nutrition. Then, highlight regulators due higher bioavailability physiological heterogeneity-targeted properties, providing theoretical foundation feed industry application. Therefore, have shown great field They can overcome limitations terms dosage side effects, which will provide unprecedented management may become major breakthrough
Language: Английский
Citations
2
Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2306 - 2306
Published: May 14, 2024
Methylglyoxal-induced ROS elevation is the primary cause of neuronal damage. Metformin a traditional hypoglycemic drug that has been reported to be beneficial nervous system. In this study, flavonoids were found enhance protective effect metformin when added at molar concentration 0.5%. The structure–activity relationship (SAR) analysis indicated ortho- substitution in B ring, and absence double bonds between 2 3 position combined with gallate R configuration C ring played crucial roles synergistic effects, which could for designing combination compounds. Additionally, mechanism study revealed typical flavonoid, EGCG, enhanced scavenging anti-apoptotic ability via BCL2/Bax/Cyto C/Caspase-3 pathway, synergistically inhibited expression GSK-3β, BACE-1, APP PC-12 cells used metformin. dose was only 1/4 conventional alone. These results suggested ROS-mediated apoptosis pathways related amyloid plaques (Aβ) formation can targets neuroprotective effects
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(15), P. 2654 - 2654
Published: July 26, 2024
(1) Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer. Surgical resection, tumor ablation, and transplantation are curative treatments indicated for early-stage HCC. The management intermediate advanced stages pathology based on use systemic therapies which often show important side effects. Vitamin E-derivative tocotrienols (TTs) play antitumoral properties in different tumors. Here, we analyzed activity delta-TT (δ-TT) HCC human cell lines. (2) We ability δ-TT to trigger apoptosis, induce oxidative stress, autophagy, mitophagy HepG2 line. evaluated correlation between activation autophagy with death. (3) data obtained demonstrate that exerts an antiproliferative proapoptotic effect cells. Furthermore, induces release mitochondrial ROS causes a structural functional alteration mitochondria compatible fission process. Finally, triggers selective process removing dysfunctional mitochondria. Inhibition reversed cytotoxic action δ-TT. (4) Our results through could represent potential new approach treatment
Language: Английский
Citations
1
World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(8), P. 773 - 779
Published: Aug. 26, 2024
In this editorial, we delved into the article titled “Cellular preconditioning and mesenchymal stem cell ferroptosis.” This groundbreaking study underscores a pivotal discovery: Ferroptosis, type of programmed death, drastically reduces viability donor cells (MSCs) after engraftment, thereby undermining therapeutic value cell-based therapies. Furthermore, proposes that by manipulating ferroptosis mechanisms through preconditioning, can potentially enhance survival rate functionality MSCs, ultimately amplifying their potential. Given crucial role plays in shaping outcomes deem it imperative to further investigate intricate interplay between death effectiveness MSCs.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
The selective upregulation of intracellular oxidative stress in cancer cells presents a promising approach for effective treatment. In this study, we report the integration enzyme catalytic amplification and chemical reactions β-lapachone (Lap)-loaded micellar nanoparticles (NPs), which are self-assembled from reactive oxygen species (ROS)-responsive self-immolative polymers (SIPs). This enables cyclic cells. Specifically, have developed ROS-responsive SIPs with phenylboronic ester triggering motifs hexafluoroisopropanol moieties side chains, significantly enhancing Lap loading efficiency (98%) capacity (33%) through multiple noncovalent interactions. Upon ROS activation tumor cells, Lap-loaded NPs disassemble, releasing generating additional via amplification. process elevates triggers polymer depolymerization positive feedback loop. Furthermore, degradation produces azaquinone methide intermediates, consume thiol-related substrates, disrupt redox hemostasis, further intensify stress, promote cell apoptosis. work introduces strategy to enhance by combining enzymatic reactions, providing potential pathway development highly efficient anticancer agents.
Language: Английский
Citations
0