Ferulic acid alleviates avermectin induced renal injury in carp by inhibiting inflammation, oxidative stress and apoptosis

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 149, P. 109575 - 109575

Published: April 24, 2024

Language: Английский

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AZD1390, an ataxia telangiectasia mutated inhibitor, attenuates microglia‐mediated neuroinflammation and ischemic brain injury

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(4)

Published: April 1, 2024

Abstract Aims Excessive neuroinflammation mediated mainly by microglia plays a crucial role in ischemic stroke. AZD1390, an ataxia telangiectasia mutated (ATM) specific inhibitor, has been shown to promote radio‐sensitization and survival central nervous system malignancies, while the of AZD1390 stroke remains unknown. Methods Real‐time PCR, western blot, immunofluorescence staining, flow cytometry enzyme‐linked immunosorbent assays were used assess activation release inflammatory cytokines. Behavioral tests performed measure neurological deficits. 2,3,5‐Triphenyltetrazolium chloride staining was conducted infarct volume. The NF‐κB signaling pathway explored through co‐immunoprecipitation proximity ligation assay. Results level pro‐inflammation cytokines suppressed vitro vivo. behavior deficits size partially restored with treatment experimental restrict ubiquitylation sumoylation essential regulatory subunit (NEMO) ATM‐dependent ATM‐independent way respectively, which reduced pathway. Conclusion alleviate brain injury stroke, attenuated neuroinflammation, indicated that might be attractive agent for

Language: Английский

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An Exploration of the Antioxidative and Anti-Inflammatory Role of Lactiplantibacillus plantarum 106 via Improving Mitochondrial Function

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 1981 - 1981

Published: June 24, 2024

In this present study, bioinformatics analysis and the experimental validation method were used to systematically explore antioxidant activity anti-inflammatory effect of Lactiplantibacillus plantarum A106, which was isolated from traditional Chinese pickles, on lipopolysaccharide (LPS)-induced RAW264.7 macrophages. L. A106 had a good scavenging ability for DPPH, ABTS, hydroxyl radicals. Furthermore, could increase macrophages; raise SOD GSH levels, with or without LPS sensitization; decrease MDA, TNF–α, IL–6 levels. order deeply seek role mechanism, bioinformatic analysis, including GO, KEGG, GSEA conduct an in-depth results showed that treatment macrophages significantly upregulated inflammatory-related genes revealed enrichment in inflammatory signaling pathways. Additionally, network via Cytoscape software (version 3.9.1) identified key central found also disturbed apoptosis mitochondrial function. Based above effects inflammation-related gene expression, function, apoptosis, etc., detected. The indicated restored declined expression levels crucial like TNF–α IL–6; membrane potential; apoptosis-related genes, Bcl–2, Caspase–3, Bax. These suggest exerts through regulating restoring potential.

Language: Английский

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Catalytically proficient ceria nanodots supported on redox-active mesoporous hosts for treatment of inflammatory bowel disease via efficient ROS scavenging

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(43), P. 10369 - 10382

Published: Jan. 1, 2023

Ceria nanozyme-based ROS scavengers have shown great potential in the treatment of inflammatory bowel disease (IBD) through microenvironment regulation. However, currently developed nanotherapeutics suffer from difficulties concomitantly achieving small sizes and stable interparticle dispersion which is pivotal to sufficient oxygen vacancies facilitating electron transfer storage dynamic cycling Ce3+/Ce4+ redox pairs. Herein, a hybrid nanosystem consisting ceria nanodots supported on redox-active mesoporous hosts was address challenge scavenging, particular efficient downregulation readily renewable, highly concentrated H2O2 species. Specifically, Ce4+ ions oxidized Ce3+ weakly basic solution were captured reduced time by abundant catechols polydopamine nanoparticles. This led strong restriction growth (∼2.8 nm) ion precipitation process maintenance ratio at high value 1.59 4.8 fold higher than that homogeneously nucleated Through this design, nanohybrid showed an attractive catalytic performance scavenging multiple species, particularly fast recyclable conversion H2O2. Thereby, significant suppression cytokine/chemokine secretion achieved inhibiting activation NF-κB signaling pathways (5.1 as compared those pristine nanoparticles), upregulating Nrf2 pathway, reducing proportion M1 macrophages IBD sites. Therapeutic efficiency also demonstrated effective repair intestinal mucosal barrier recovering tight junction integrity vivo. study sheds light employment support catalysts for advancing anti-inflammation applications boosting performance.

Language: Английский

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Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway

Annals of Anatomy - Anatomischer Anzeiger, Journal Year: 2023, Volume and Issue: 251, P. 152180 - 152180

Published: Oct. 23, 2023

Language: Английский

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