Bibliometric analysis of the inflammation expression after spinal cord injury: current research status and emerging frontiers DOI Creative Commons
Xiaoyu Li,

Kun Jiao,

Chen Liu

et al.

Spinal Cord, Journal Year: 2024, Volume and Issue: 62(11), P. 609 - 618

Published: Oct. 3, 2024

Abstract Study design Bibliometric analysis. Objective To analyze literature on inflammatory expression following spinal cord injury, highlighting development trends, current research status, and potential emerging frontiers. Setting Not applicable. Methods Articles were retrieved using terms related to injury responses from the Web of Science Core Collection, covering January 1, 1980, May 23, 2024. Tools like CiteSpace VOSviewer assessed landscape, evaluating core authors, journals, contributing countries. Keyword co-occurrence analyses identified trends. Results A total 2504 articles retrieved, showing a consistent increase in publications. The Journal Neurotrauma had highest publication volume influence. most prolific author was Cuzzocrea S, with Popovich PG having H-index. China led number publications, followed closely by United States, which impact extensive international collaboration. Research mainly focused nerve function recovery, glial scar formation, oxidative stress. Future is expected investigate cellular autophagy, vesicular transport, signaling pathways. Conclusion growing interest inflammation caused evident, focusing stress, scar, neurological recovery. directions include exploring autophagy extracellular vesicles for new therapies. Interdisciplinary clinical trials are essential validating treatments. Biomarker discovery crucial diagnosis monitoring, while understanding pathways vital drug development. Global cooperation needed accelerate application scientific findings, improving treatment.

Language: Английский

Multidimensional biological activities of resveratrol and its prospects and challenges in the health field DOI Creative Commons

Xi Yu,

Yuanqiang Jia,

Feiyue Ren

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 12, 2024

Resveratrol (RES) is a naturally occurring polyphenolic compound. Recent studies have identified multiple potential health benefits of RES, including antioxidant, anti-inflammatory, anti-obesity, anticancer, anti-diabetic, cardiovascular, and neuroprotective properties. The objective this review to summarize analyze the on biological activities RES in disease prevention treatment, as well its metabolism bioavailability. It also discusses challenges clinical application future research directions. exhibits significant treatment many diseases. direction should focus improving bioavailability, conducting more trials determine effectiveness humans, investigating mechanism action. Once these been overcome, expected become an effective intervention.

Language: Английский

Citations

6
Nrf2 Signaling Pathway: Focus on Oxidative Stress in Spinal Cord Injury DOI

Chun-Lin Xiao,

Hong-Tong Lai,

Jiangjun Zhou

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Language: Английский

Citations

6
Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review DOI Creative Commons

Wei She,

Jian‐Qiang Su, Wenjian Ma

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Spinal cord injury (SCI) is a severe traumatic condition that frequently results in various neurological disabilities, including significant sensory, motor, and autonomic dysfunctions. Ferroptosis, recently identified non-apoptotic form of cell death, characterized by the accumulation reactive oxygen species (ROS), intracellular iron overload, lipid peroxidation, ultimately culminating death. Recent studies have demonstrated ferroptosis plays critical role pathophysiology SCI, contributing significantly to neural demise. Three key cellular enzymatic antioxidants such as glutathione peroxidase 4 (GPX4), suppressor protein 1 (FSP1), dihydroorotate dehydrogenase (DHODH), been elucidated crucial components defense against ferroptosis. Natural products, which are bioactive compounds mostly derived from plants, garnered considerable attention for their potential therapeutic effects. Numerous reported several natural products can effectively mitigate death alleviate SCI symptoms. This review summarizes fifteen containing (-)-Epigallocatechin-3-gallate (EGCG), Proanthocyanidin, Carnosic acid, Astragaloside IV, Trehalose, 8-gingerol, Quercetin, Resveratrol, Albiflorin, Alpha-tocopherol, Celastrol, Hispolon, Dendrobium Nobile Polysaccharide, Silibinin, Tetramethylpyrazine shown promise treating inhibiting Additionally, this provides an overview mechanisms involved these proposes perspectives guide future research directions.

Language: Английский

Citations

0
Unlocking Synergistic Hepatoprotection: Dapagliflozin and Silymarin Combination Therapy Modulates Nuclear Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway in Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Rats DOI Creative Commons
Shakta Mani Satyam, Laxminarayana Kurady Bairy, Abdul Rehman

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 473 - 473

Published: June 26, 2024

This study was aimed to investigate the hepatoprotective potential of dapagliflozin and silymarin alone in combination combat carbon tetrachloride (CCl

Language: Английский

Citations

3
Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review DOI Open Access

Qiongxia Lv,

Wenjing Xu, Fan Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11003 - 11003

Published: Oct. 13, 2024

Zearalenone (ZEA) is a mycotoxin produced by Fusarium spp. fungi and widely found in moldy corn, wheat, barley, other grains. ZEA distributed to the whole body via blood circulation after metabolic transformation animals. Through oxidative stress, immunosuppression, apoptosis, autophagy, mitochondrial dysfunction, leads hepatitis, neurodegenerative diseases, cancer, abortion, stillbirth female animals, decreased sperm motility male In recent years, due influence of climate, storage facilities, factors, problem pollution global food crops has become particularly prominent, resulting serious problems for animal husbandry feed industries, threatening human health. Resveratrol (RSV) natural product with therapeutic activities such as anti-inflammatory, antioxidant, anticancer properties. RSV can alleviate ZEA-induced toxic effects targeting signaling pathways NF-κB, Nrf2/Keap1, PI3K/AKT/mTOR attenuating damage, inflammatory response, regulating cellular autophagy. Therefore, this paper provides review protective effect against toxicity its molecular mechanism, discusses safety potential clinical applications search detoxification agents.

Language: Английский

Citations

2
Bibliometric analysis of the inflammation expression after spinal cord injury: current research status and emerging frontiers DOI Creative Commons
Xiaoyu Li,

Kun Jiao,

Chen Liu

et al.

Spinal Cord, Journal Year: 2024, Volume and Issue: 62(11), P. 609 - 618

Published: Oct. 3, 2024

Abstract Study design Bibliometric analysis. Objective To analyze literature on inflammatory expression following spinal cord injury, highlighting development trends, current research status, and potential emerging frontiers. Setting Not applicable. Methods Articles were retrieved using terms related to injury responses from the Web of Science Core Collection, covering January 1, 1980, May 23, 2024. Tools like CiteSpace VOSviewer assessed landscape, evaluating core authors, journals, contributing countries. Keyword co-occurrence analyses identified trends. Results A total 2504 articles retrieved, showing a consistent increase in publications. The Journal Neurotrauma had highest publication volume influence. most prolific author was Cuzzocrea S, with Popovich PG having H-index. China led number publications, followed closely by United States, which impact extensive international collaboration. Research mainly focused nerve function recovery, glial scar formation, oxidative stress. Future is expected investigate cellular autophagy, vesicular transport, signaling pathways. Conclusion growing interest inflammation caused evident, focusing stress, scar, neurological recovery. directions include exploring autophagy extracellular vesicles for new therapies. Interdisciplinary clinical trials are essential validating treatments. Biomarker discovery crucial diagnosis monitoring, while understanding pathways vital drug development. Global cooperation needed accelerate application scientific findings, improving treatment.

Language: Английский

Citations

1