Crosstalk between Epigenetics and Metabolic Reprogramming in Metabolic Dysfunction-Associated Steatotic Liver Disease-Induced Hepatocellular Carcinoma: A New Sight DOI Creative Commons
Anqi Li, Rui Wang, Yu-Qiang Zhao

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 325 - 325

Published: June 8, 2024

Epigenetic and metabolic reprogramming alterations are two important features of tumors, their reversible, spatial, temporal regulation is a distinctive hallmark carcinogenesis. Epigenetics, which focuses on gene regulatory mechanisms beyond the DNA sequence, new entry point for tumor therapy. Moreover, drives hepatocellular carcinoma (HCC) initiation progression, highlighting significance metabolism in this disease. Exploring inter-regulatory relationship between epigenetic modification has become one hot directions current research. As viral etiologies have given way to dysfunction-associated steatotic liver disease (MASLD)-induced HCC, it urgent that complex molecular pathways linking them hepatocarcinogenesis be explored. However, how aberrant crosstalk modifications affects MASLD-induced HCC lacks comprehensive understanding. A better understanding linkages necessary improve treatment strategies. For reason, review examines interwoven landscape carcinogenesis context focusing regulating development interactions while also updating advances modification-based therapeutic drugs HCC.

Language: Английский

Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance DOI Creative Commons
Hong Lin, Di Wang, Pinghan Wang

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: July 18, 2022

Abstract The resistance of tumor cells to therapy severely impairs the efficacy treatment, leading recurrence and metastasis various cancers. Clarifying underlying mechanisms therapeutic may provide new strategies for overcoming cancer resistance. N6-methyladenosine (m6A) is most prevalent RNA modification in eukaryotes, involved regulation splicing, translation, transport, degradation, stability processing, thus affecting several physiological processes progression. As a novel type multifunctional non-coding RNAs (ncRNAs), circular (circRNAs) have been demonstrated play vital roles anticancer therapy. Currently, accumulating studies revealed mutual m6A circRNAs, their interaction can further influence sensitivity treatment. In this review, we mainly summarized recent advances circRNAs modulation resistance, as well interplay potential mechanisms, providing promising insights future directions reversal cancer.

Language: Английский

Citations

84
m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion DOI Creative Commons
Xiaoxue Cao,

Qishun Geng,

Danping Fan

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 1, 2023

Abstract N6-methyladenosine (m 6 A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m A writers, erasers, and readers, modulation involved myriad physiological pathological processes. Extensive studies have demonstrated diverse tumours, with effects on tumorigenesis, metastasis, resistance. Recent evidence has revealed an emerging role of tumour immunoregulation, divergent patterns been microenvironment. To depict regulatory immune microenvironment (TIME) its effect evasion, this review focuses TIME, which characterized hypoxia, metabolic reprogramming, acidity, immunosuppression, outlines A-regulated TIME evasion under stimuli. Furthermore, anti-tumour cells are summarized.

Language: Английский

Citations

56
Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy DOI Open Access
Tasneem Abaza, Mostafa K. Abd El‐Aziz,

Kerolos Ashraf Daniel

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16484 - 16484

Published: Nov. 18, 2023

Hepatocellular carcinoma (HCC) is a highly fatal malignancy with limited therapeutic options and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint inhibitors (ICIs) have emerged new paradigm shift in oncology. ICIs, programmed cell death protein 1 (PD-1) inhibitors, provided source of hope for patients advanced HCC. Yet, the eligibility criteria HCC ICIs are still missing piece puzzle. Circular RNAs (circRNAs) recently class non-coding that play fundamental role cancer pathogenesis. Structurally, circRNAs resistant to exonucleolytic degradation longer half-life than their linear counterparts. Functionally, possess capability influence various facets tumor microenvironment, especially at tumor–immune synapse. Notably, been observed control expression molecules within cells, potentially impeding effectiveness ICIs. Therefore, this renders them potential cancer-immune biomarkers diagnosis, prognosis, regimen determinants. In review, authors shed light on structure functional roles and, most importantly, highlight promising immunomodulation

Language: Английский

Citations

49
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism DOI Creative Commons
Shiwei Yue, Hailing Liu,

Hong-Fei Su

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 15, 2023

Abstract Glycolytic reprogramming is one of the most important features cancer and plays an integral role in progression cancer. In cells, changes glucose metabolism meet needs self-proliferation, angiogenesis lymphangiogenesis, metastasis, also affect immune escape, prognosis evaluation therapeutic effect The n6-methyladenosine (m6A) modification RNA widespread eukaryotic cells. Dynamic reversible m6A modifications are widely involved regulation stem cell renewal differentiation, tumor therapy resistance, microenvironment, metabolism. Lately, more evidences show that can glycolysis process tumors a variety ways to regulate biological behavior tumors. this review, we discussed genesis development, elaborated detail profound impact on different by regulating glycolysis. We believe modified has great significance potential for treatment.

Language: Английский

Citations

44
Circular RNA in cancer DOI
Vanessa M. Conn, Arul M. Chinnaiyan, Simon J. Conn

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(9), P. 597 - 613

Published: July 29, 2024

Language: Английский

Citations

40
Critical roles and clinical perspectives of RNA methylation in cancer DOI Creative Commons

Ganglei Li,

Qinfan Yao,

Peixi Liu

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(5)

Published: May 1, 2024

Abstract RNA modification, especially methylation, is a critical posttranscriptional process influencing cellular functions and disease progression, accounting for over 60% of all modifications. It plays significant role in metabolism, affecting processing, stability, translation, thereby modulating gene expression cell essential proliferation, survival, metastasis. Increasing studies have revealed the disruption metabolism mediated by methylation has been implicated various aspects cancer particularly metabolic reprogramming immunity. This profound implications tumor growth, metastasis, therapy response. Herein, we elucidate fundamental characteristics their impact on expression. We highlight intricate relationship between reprogramming, immunity, using well‐characterized phenomenon as framework to discuss methylation's specific roles mechanisms progression. Furthermore, explore potential targeting regulators novel approach therapy. By underscoring complex which contributes this review provides foundation developing new prognostic markers therapeutic strategies aimed at treatment.

Language: Английский

Citations

17
Circ‐CTNNB1 drives aerobic glycolysis and osteosarcoma progression via m6A modification through interacting with RBM15 DOI Creative Commons
Feng Yang, Yang Liu, Jun Xiao

et al.

Cell Proliferation, Journal Year: 2022, Volume and Issue: 56(1)

Published: Oct. 1, 2022

Circular RNAs (circRNAs) are a subclass of noncoding RNAs, playing essential roles in tumorigenesis and aggressiveness. Recent studies have revealed the pivotal functions circ-CTNNB1 (a circular RNA derived from CTNNB1) cancer progression. However, little is known about role osteosarcoma (OS), highly malignant bone tumour children adolescents.Circ-CTNNB1 was analysed by qRT-PCR, results were confirmed Sanger sequencing. The interaction effects between binding motif protein 15 (RBM15) through biotin-labelled pull-down mass spectrometry, vitro binding, electrophoretic mobility shift assays. In vivo experiments performed to evaluate biological underlying mechanisms RBM15 OS cells.Circ-CTNNB1 expressed tissues predominantly detected nucleus cells. Ectopic expression promoted growth, invasion, metastasis cells vivo. Mechanistically, interacted with subsequently hexokinase 2 (HK2), glucose-6-phosphate isomerase (GPI) phosphoglycerate kinase 1 (PGK1) N6-methyladenosine (m6A) modification facilitate glycolysis process activate progression.Circ-CTNNB1 drives aerobic progression facilitating RBM15-mediated m6A modification.

Language: Английский

Citations

49
Exosomal circRNAs in cancer: Implications for therapy resistance and biomarkers DOI
Zhengjun Lin,

Yuqiao Ji,

Jian Zhou

et al.

Cancer Letters, Journal Year: 2023, Volume and Issue: 566, P. 216245 - 216245

Published: May 27, 2023

Language: Английский

Citations

37
The emerging importance role of m6A modification in liver disease DOI Open Access

Sheng Wang,

Songsen Gao,

Wufei Ye

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114669 - 114669

Published: April 8, 2023

N6-methyladenosine (m6A) modification, as one of the most common types inner RNA modification in eukaryotes, plays a multifunctional role normal and abnormal biological processes. This type is modulated by m6A writer, eraser reader, which turn impact various processes metabolism, such processing, translation, nuclear export, localization decay. The current academic view holds that exerts crucial post-transcriptional modulation gene expression, involved multiple cellular functions, developmental disease However, potential molecular mechanism specific development liver have not been fully elucidated. In our review, we summarized latest research progress on disease, explored how these novel findings reshape knowledge metabolism. addition, also illustrated effect regeneration to prompt further exploration physiology pathology, providing new insights references for search therapeutic targets disease.

Language: Английский

Citations

30
Novel insight into RNA modifications in tumor immunity: Promising targets to prevent tumor immune escape DOI Creative Commons
Yuxin Kong, Jie Yu, Shengfang Ge

et al.

The Innovation, Journal Year: 2023, Volume and Issue: 4(4), P. 100452 - 100452

Published: May 29, 2023

•RNA modification is a novel hotspot of epigenetic research, affecting wide range physiological and pathological processes.•RNA plays an important role in tumor immunity.•RNA may be potential clinical therapeutic target to prevent immune escape. An immunosuppressive state typical feature the microenvironment. Despite dramatic success checkpoint inhibitor (ICI) therapy preventing cell escape from surveillance, primary acquired resistance have limited its use. Notably, recent trials shown that drugs can significantly improve outcome ICI various cancers, indicating importance modifications regulation tumors. Recently, RNA (N6-methyladenosine [m6A], N1-methyladenosine [m1A], 5-methylcytosine [m5C], etc.), areas been play crucial roles protumor antitumor immunity. In this review, we provide comprehensive understanding how m6A, m1A, m5C function immunity by directly regulating different cells as well indirectly through mechanisms, including modulating expression checkpoints, inducing metabolic reprogramming, secretion immune-related factors. Finally, discuss current status strategies targeting escape, highlighting their potential.

Language: Английский

Citations

25