Environmental Research, Journal Year: 2023, Volume and Issue: 229, P. 115939 - 115939
Published: April 23, 2023
Language: Английский
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: Aug. 15, 2023
Abstract Glycolytic reprogramming is one of the most important features cancer and plays an integral role in progression cancer. In cells, changes glucose metabolism meet needs self-proliferation, angiogenesis lymphangiogenesis, metastasis, also affect immune escape, prognosis evaluation therapeutic effect The n6-methyladenosine (m6A) modification RNA widespread eukaryotic cells. Dynamic reversible m6A modifications are widely involved regulation stem cell renewal differentiation, tumor therapy resistance, microenvironment, metabolism. Lately, more evidences show that can glycolysis process tumors a variety ways to regulate biological behavior tumors. this review, we discussed genesis development, elaborated detail profound impact on different by regulating glycolysis. We believe modified has great significance potential for treatment.
Language: Английский
Citations
44
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: March 27, 2024
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding pathophysiology, inspiring development therapeutics. As a crucial component epigenetics at post-transcription level, RNA modification significantly determines fates, further affecting various biological processes cellular phenotypes. To be noted, immunometabolism defines the metabolic alterations occur on immune cells different stages immunological contexts. In this review, we characterize distribution features, modifying mechanisms functions 8 modifications, including N6-methyladenosine (m6A), N6,2'-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C), N4-acetylcytosine (ac4C), N7-methylguanosine (m7G), Pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing, which are relatively most studied types. Then regulatory roles these diverse health disease contexts comprehensively described, categorized as glucose, lipid, amino acid, mitochondrial metabolism. And highlight regulation modifications immunometabolism, influencing responses. Above all, provide thorough discussion about clinical implications metabolism-targeted therapy immunotherapy, progression modification-targeted agents, its potential RNA-targeted Eventually, give legitimate perspectives for future researches field from methodological requirements, mechanistic insights, to therapeutic applications.
Language: Английский
Citations
34
Journal of bone oncology, Journal Year: 2024, Volume and Issue: 44, P. 100521 - 100521
Published: Jan. 4, 2024
Metabolic reprogramming is an adaptive response of tumour cells under hypoxia and low nutrition conditions. There increasing evidence that glucose metabolism can regulate the growth metastasis osteosarcoma (OS). Reprogramming in progress OS bring opportunities for early diagnosis treatment OS. Previous research mainly focused on glycolytic pathway metabolism, often neglecting tricarboxylic acid cycle pentose phosphate pathway. However, are also involved progression closely related to this disease. The has not yet been summarized. In review, we discuss abnormal expression key molecules summarize signaling pathways occurrence development addition, some targeted drugs pathways, which lead effective strategies
Language: Английский
Citations
10
BMC Cancer, Journal Year: 2023, Volume and Issue: 23(1)
Published: July 20, 2023
Abstract Background RNA binding motif protein 15 (RBM15), a writer of N6-methyladenosine (m6A) methylation, contributes significantly to the development various tumors. However, function RBM15 in cervical cancer (CC) has not been determined. Methods Based on GSE9750, GSE63514, and m6A datasets, m6A-related differentially expressed genes (DEGs) were screened out. The hub identified by generating Protein-Protein Interaction (PPI) network. RT-qPCR was conducted assess mRNA expression genes. CCK8, scratch wound healing, transwell assays utilized examine influence HeLa SiHa cells. Tumor xenograft models used effects tumorigenesis. A mechanistic analysis CC tumors using GeneCards Coxpresdb databases, followed Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis, pathway-related subsequently validated Western blotting. Results Five DEGs screened, including WTAP, RBM15, CBLL1, YTHDC2. Among them, YTHDC2 can be as biomarkers for CC. considerably increased, while downregulated. Knockdown suppressed proliferation, invasion, migration cells Moreover, knockdown reduced levels proteins related JAK-STAT pathway. Conclusions inhibited progression cells, which probably inhibiting pathway
Language: Английский
Citations
19
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Sept. 18, 2023
Abstract Cells that undergo normal differentiation mainly rely on mitochondrial oxidative phosphorylation to provide energy, but most tumour cells aerobic glycolysis. This phenomenon is called the "Warburg effect". Phosphoglycerate kinase 1 (PGK1) a key enzyme in PGK1 involved glucose metabolism as well variety of biological activities, including angiogenesis, EMT, mediated autophagy initiation, metabolism, DNA replication and repair, other processes related tumorigenesis development. Recently, an increasing number studies have proven plays important role cancer. In this manuscript, we discussed effects structure, function, molecular mechanisms underlying regulation initiation progression Additionally, associated with chemotherapy resistance prognosis patients. review presents overview different roles played by during tumorigenesis, which will help design experimental involving enhance potential for use therapeutic target
Language: Английский
Citations
18
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Feb. 19, 2024
Thyroid hormone receptor interactor 6 (TRIP6) it is an adaptor protein belonging to the zyxin family of LIM proteins, participating in signaling events through interactions with various molecules. Despite this, TRIP6's role colorectal cancer (CRC), particularly its correlation glucose metabolism and immune cell infiltration, remains unclear. Through TCGA GEO databases, we obtained RNA sequencing data facilitate our in-depth study analysis TRIP6 expression. To investigate prognostic value CRC, also used univariate Cox regression analysis. In addition, this covered a series analyses, including clinicopathological analysis, functional enrichment glycolysis immunoinfiltration checkpoint angiogenesis gain comprehensive understanding biological phenomenon. It has been found that expression significantly upregulated CRC correlates stage disease. Its overexpression portends worse survival time. Functional reveals associated focal adhesion glycolysis. Mechanistically, appears exert tumorigenic effect by regulating glycolysis-related gene GPI. A higher level increase number iDC cells decrease Th1 cells. Also, may promote tumor promoting JAG2. Our uncovers upregulation illuminating diagnostic within context. Furthermore, examine relationship between levels, glycolysis, infiltration. This underscores potential as biomarker for treatment therapeutic target.
Language: Английский
Citations
6
Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(2)
Published: Feb. 7, 2023
Abstract Bone metastasis is the most happened metastatic event in prostate cancer (PCa) and needs a large effort treatment. When PCa metastasizes to bone, new microenvironment can induce epigenome reprogramming stemness remodeling of cells, thereby increasing adaptability cells bone microenvironment, this even leads occurrence secondary tumor metastasis. Our group has previously found that RNA binding motif 3 (RBM3) affects stem cell-like properties by interfering with alternative splicing CD44. However, whether RBM3, as stress-response protein, resist microenvironmental particularly remains unknown. By co-culturing osteoblasts mimic metastases, we RBM3 upregulates N6-methyladenosine (m 6 A) methylation on mRNA catenin beta 1 (CTNNB1) manner dependent methyltransferase (METTL3), an N6-adenosine-methyltransferase complex catalytic subunit. Consequently, modification results decreased stability CTNNB1 followed inactivation Wnt signaling, which ultimately inhibits osteoblasts. Thus, present study may extend our understanding inhibitory role PCa.
Language: Английский
Citations
15
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 14, 2024
Abstract Skeletal system disease (SSD) is defined as a class of chronic disorders skeletal with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position adenosine in RNA, reversible dynamic modification posttranscriptional mRNA. Evidences suggest that m6A modifications play crucial role regulating biological processes all kinds diseases, such malignancy. Recently studies have revealed most abundant epigentic modification, involved progression SSD. However, function SSD not fully illustrated. Therefore, make clear relationship between pathogenesis might provide novel sights for prevention targeted treatment This article will summarize recent advances regulation SSD, including osteoporosis, osteosarcoma, rheumatoid arthritis osteoarthritis, discuss potential clinical value, research challenge future prospect
Language: Английский
Citations
5
JACC Basic to Translational Science, Journal Year: 2024, Volume and Issue: 9(5), P. 631 - 648
Published: April 10, 2024
RNA-binding proteins play multiple roles in several biological processes. However, the of RBM15—an important protein and a significant regulator RNA methylation—in cardiovascular diseases remain elusive. This study aimed to investigate function RBM15 its fundamental mechanisms myocardial infarction (MI). Methylated immunoprecipitation sequencing was used explore N6-methyladenosine (m6A) difference between MI normal tissues. Our findings showed elevated level m6A MI, transcription profile both main overexpression attenuated apoptosis cardiomyocytes improved cardiac mice after MI. Then, we one target NEDD8 activating enzyme E1 subunit inhibitor (MLN4924) impact targets on cardiomyocytes. Finally, enhanced methylation presence led increased expression stability subunit. suggest that is protective mechanism significantly upregulated promotes function. affected by stabilizing cell function, which might provide new insight into therapy.
Language: Английский
Citations
5
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: June 10, 2024
In the contemporary epoch, cancer stands as predominant cause of premature global mortality, necessitating a focused exploration molecular markers and advanced therapeutic strategies. N6-methyladenosine (m 6 A), most prevalent mRNA modification, undergoes dynamic regulation by enzymes referred to methyltransferases (writers), demethylases (erasers), effective proteins (readers). Despite lacking methylation activity, RNA-binding motif protein 15 (RBM15), member m A writer family, assumes crucial role in recruiting methyltransferase complex (MTC) binding mRNA. Although impact modifications on has garnered widespread attention, RBM15 been relatively overlooked. This review briefly outlines structure operational mechanism, delineates unique various cancers, shedding light its basis providing groundwork for potential tumor-targeted therapies.
Language: Английский
Citations
5