Conventional and innovative approaches to black fungi control for stone heritage preservation DOI Creative Commons
Domenico Celi, Massimiliano Marvasi, Brunella Perito

et al.

IUBMB Life, Journal Year: 2025, Volume and Issue: 77(3)

Published: March 1, 2025

Black Meristematic Fungi (BMF) are characterized by a thick melanized cell wall and an isodiametric cellular expansion. BMF represent one of the most damaging groups microorganisms causing deterioration outdoor exposed stone monuments mainly due to formation dark spots patches leading darkening their surface, cracking, bio-pitting. among stress-resistant organisms on Earth, known for remarkable ability withstand solar radiation, desiccation, extreme temperature fluctuations, which has led widespread distribution across globe. These features make very difficult remove restrict, representing challenge restorers. Despite number scientific works about isolation ecology, little is response antimicrobial treatments. Conventional biocides remain used treatment control biodeterioration artworks. In recent years, interest in alternative safer treatments risen conservation strategies. The efficacy against evaluated is, however, still low. aim this review assess existing studies regarding both conventional innovative This will encompass in-depth examination methodologies application evaluation Furthermore, we highlight future research directions that contribute more informed selection effective anti-BMF interventions preservation. We underscore significance pioneering, environmentally low-impact solutions.

Language: Английский

Chemical Composition, Biological Activity, and Potential Uses of Oregano (Origanum vulgare L.) and Oregano Essential Oil DOI Creative Commons
Renata Nurzyńska-Wierdak, Magdalena Walasek-Janusz

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 267 - 267

Published: Feb. 18, 2025

Medicinal aromatic plants (MAPs) are a rich and diverse source of traditional modern medicines. Aromatic contain valuable essential oils that exhibit numerous biological activities. Essential used in pharmaceutical production, cosmetics, food preservation to ensure the microbiological stability products. Plants from Lamiaceae family, including Origanum vulgare L., raw materials with antimicrobial antioxidant properties, they can be utilized production new drugs other bioproducts. Oregano is an example plant great potential, known for its health-related culinary applications growing significance medicines, antiseptics, preservatives. This work aims consolidate current research results on occurrence, acquisition, use, medicinal dietary value common oregano oil. The obtained indicate plant, serving as natural antiseptics protective agents. oil, thymol carvacrol, has number health-promoting properties. These compounds (also present extracts) significant antioxidant, anti-inflammatory, antiangiogenic, anticancer, findings highlight promising role these potential structures search antibiofilm

Language: Английский

Citations

3
Thymus Vulgaris Oil Nanoemulsion: Synthesis, Characterization, Antimicrobial and Anticancer Activities DOI Creative Commons
Ahmed S. Doghish, Amr M. Shehabeldine, Hesham N. Elmahdy

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(19), P. 6910 - 6910

Published: Oct. 2, 2023

Essential oil nanoemulsions have received much attention due to their biological activities. Thus, a thyme essential nanoemulsion (Th-nanoemulsion) was prepared using safe and eco-friendly method. DLS TEM were used characterize the Th-nanoemulsion. Our findings showed that spherical ranged in size from 20 55.2 nm. The micro-broth dilution experiment evaluate vitro antibacterial activity of Th-emulsion MIC50 values thymol 62.5 mg/mL against Escherichia coli Klebsiella oxytoca, 250 Bacillus cereus, 125 Staphylococcus aureus. Meanwhile, it emerged four strains not detected. Moreover, Th-nanoemulsion exhibited promising antifungal toward A. brasiliensis fumigatus, where inhibition zones 20.5 ± 1.32 26.4 1.34 mm, 12.5 6.25 mg/mL, respectively. On other hand, displayed weak C. albicans zone 12.0 0.90 MIC 50 mg/mL. Also, activity, but lower than Th-nanoemulsion, all tested fungal strains, range 12.5-50 anticancer effects Taxol, Th-emulsion, evaluated standard MTT method breast cancer (MCF-7) hepatocellular carcinoma (HepG2). Additionally, concentration VEGFR-2 measured, activities caspase-8 (casp-8) caspase-9 (casp-9) evaluated. cytotoxic effect most potent MCF-7 cell line after treatment (20.1 0.85 µg/mL), 125.1 5.29 µg/mL treatment. lowest half-maximal inhibitory (IC50) value, 20.1 µg/mL, achieved when treated with In addition, treatments on cells led highest elevations casp-8 casp-9 (0.66 0.042 ng/mL 17.8 0.39 pg/mL, respectively) compared those treatments. comparison (0.982 0.017 ng/mL), (0.672 0.019ng/mL). conclusion, successfully appeared nanoform shape according TEM, also antibacterial, antifungal, as well

Language: Английский

Citations

28
Investigating wound healing potential of sesamol loaded solid lipid nanoparticles: Ex-vivo, in vitro and in-vivo proof of concept DOI
Parneet Kaur Deol, Indu Pal Kaur,

Ravi Dhiman

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 654, P. 123974 - 123974

Published: March 5, 2024

Language: Английский

Citations

11
A novel nanoemulsion based on clove and thyme essential oils: Characterization, antibacterial, antibiofilm and anticancer activities DOI Creative Commons
Amr H. Hashem, Ahmed S. Doghish, Ahmed Ismail

et al.

Electronic Journal of Biotechnology, Journal Year: 2024, Volume and Issue: 68, P. 20 - 30

Published: Jan. 3, 2024

Essential oil nanoemulsions have received much attention in the last period due to their ability fight microbes and cancers. In current study, clove thyme essential oils CL+TH-emulsion CL+TH-nanoemulsion were prepared through an eco-friendly method. The was characterized using DLS TEM analyses. Results revealed that droplets spherical shape nanoform size (68.6 nm) with PDI 0.281. MIC concentrations of against tested bacteria found be between 6.25 25 mg/mL. After being exposed MICs CL+TH-nanoemulsion, which additionally prompted 1.43 log 3.12 declines, accordingly, as opposed untreated (Control), number cells grown generated biofilms decreased. Furthermore, exhibited anticancer activity more than toward HepG2 MCF-7. Also, effect is effective significantly cytotoxic taxol on Besides, both emulsions increased rate apoptosis decreased cell viability % MCF-7 by increasing caspases 8 9. Moreover, CL+TH-nano emulsion VEGFR-2 a pronounced manner taxol. Conclusions had antibacterial, antibiofilm well properties, can used different biomedical applications after extensive studies vivo.

Language: Английский

Citations

10
Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics DOI Creative Commons
Sijongesonke Peter, Namhla Sotondoshe, Blessing A. Aderibigbe

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2277 - 2277

Published: May 12, 2024

Cancer is ranked among lethal diseases globally, and the increasing number of cancer cases deaths results from limited access to effective therapeutics. The use plant-based medicine has been gaining interest several researchers. Carvacrol its isomeric compound, thymol, are extracts that possess biological activities, such as antimalarial, anticancer, antifungal, antibacterial. However, their efficacy compromised by poor bioavailability. Thus, medicinal scientists have explored synthesis hybrid compounds containing pharmacophores enhance therapeutic improve Hence, this review a comprehensive report on carvacrol isomer, with potent anticancer antibacterial agents reported between 2020 2024. Furthermore, structural activity relationship (SAR) recommended future strategies further effects will be discussed.

Language: Английский

Citations

10
Development of Alginate-Chitosan Bioactive Films Containing Essential Oils for Use in Food Packaging DOI Creative Commons
Carla Guzmán, Arash Moeini, Patricia E. Oliveira

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 256 - 256

Published: Jan. 15, 2025

The effect on the physical, mechanical, and antibacterial properties of films composed alginate-chitosan with incorporation oregano (EOO) or thyme (EOT) essential oils was evaluated. These showed a thickness between 37.7 38.2 µm, no significant differences for oil content. Water vapor permeability decreased from 4.03 (oil-free film) to 1.65 (g/msPa) × 10−9 in 3% EO. Mechanical reflected reduction tensile strength (TS) 73 films) values 34 38 MPa EO, while elongation (E%) increased 4.8% 10.4–11.8%. Regarding capacity, as concentration increases, capacity also increases. On average, increase 1.0% 3.0% EOO antimicrobial against Gram-negative Gram-positive bacteria. outperformed EOT E. coli L. monocytogenes. In addition, 2–3% dark yellow color compared control. results suggest that addition can be promising food packaging applications ability improve safety product shelf life by achieving functional characteristics.

Language: Английский

Citations

1
The Antimicrobial Effect of Thymol and Carvacrol in Combination with Organic Acids Against Foodborne Pathogens in Chicken and Beef Meat Fillets DOI Creative Commons
Ioanna Mantzourani,

Maria Daoutidou,

Athanasios Alexopoulos

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 182 - 182

Published: Jan. 16, 2025

Bioactive compounds and organic acids are applied to a wide range of foods against different types foodborne pathogens. In the present study, carvacrol thymol (1000 mg/L) were in wine-based marinades, alone or combination with them tartaric acid, malic ascorbic citric acetic acid (in concentration 0.1% w/v), chicken beef fillets their antimicrobial activity, antioxidant capacity, pH estimated during refrigerated storage. Likewise, activity was recorded Enterobacteriaceae, total mesophilic bacteria, yeasts/molds, lactic bacteria. The outcome demonstrated that both meats kept under similar storage conditions (4 °C/9 days) exhibited lower microbial growth, particularly when treated carvacrol—thymol marinades may extend shelf-life. This action more pronounced samples. phenolic content (TPC) determined using Folin−Ciocalteau method ABTS DPPH radical scavenging methods, respectively. results revealed and/or had greater TPC activity. values respective an upturn Consequently, these even at low concentrations, could be used as natural preservatives meat products.

Language: Английский

Citations

1
Enhanced antimicrobial effects of carvacrol against methicillin-resistant Staphylococcus aureus strains using niosome formulations DOI Creative Commons

Ronak Bakhtiari,

Marziyeh Ansari Shiri,

Mohammad Reza Mohammadi

et al.

Revista Argentina de Microbiología, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Thymol: Use in Antimicrobial Packaging DOI
Carol López de Dicastillo,

A. Torres,

Raquel Heras-Mozos

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 759 - 772

Published: Jan. 1, 2025

Language: Английский

Citations

1
Aromatic Herbs as a Source of Bioactive Compounds: An Overview of Their Antioxidant Capacity, Antimicrobial Activity, and Major Applications DOI Creative Commons
Leontina Grigore‐Gurgu, Loredana Dumitrașcu, Iuliana Aprodu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1304 - 1304

Published: March 14, 2025

Many aromatic herbs are conventionally used for flavoring various foods, but receive wide attention because of the variety health-related properties. The can be either fresh or as dried powders and in form extracts, essential oils, purified metabolites. In this review, main functional properties, terms antioxidant antimicrobial applications some commonly from Lamiaceae family, discussed. Herbs like oregano, rosemary, sage, thyme, summer savory, marjoram, basil possess high levels bioactive phytochemicals. They particularly rich phenolic acids, flavones, diterpenes, flavanones, with beneficial effects. phytochemical profile plants is highly influenced by genetic factors, environmental conditions, their interaction. cases extracts extraction method has a strong effect on final composition herb products. Most these related to antioxidant, antimicrobial, particular, oils have multiple fields food, feed, pharmaceutical, cosmetics, biopesticides, textile industries.

Language: Английский

Citations

1