Mitochondrion, Journal Year: 2024, Volume and Issue: 80, P. 101979 - 101979
Published: Nov. 5, 2024
Language: Английский
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(10), P. 1479 - 1490
Published: Oct. 2, 2024
Nanoparticles (NPs) are widely used in the pharmaceutical field to treat various human disorders. Among these, lipid-based NPs (LNPs), including solid lipid nanoparticles (SLN) and nanostructured carriers (NLC), favored for drug/bioactive delivery due their high stability, biocompatibility, encapsulation efficiency, sustained/controlled release. These properties make them particularly suitable as of compounds derived from plant sources.
Language: Английский
Citations
5
Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 22 - 22
Published: Jan. 27, 2025
Nowadays, skin is one of the organs most commonly affected by diseases (infections, inflammations, and injuries) due to exposure external environment. Although topical treatment represents suitable administration route, it poorly effective low permeability drug through skin. Skin delivery lipid nanocarriers (LNs) appears be a therapeutic strategy overcome these issues, allowing reach or systemic effect. Several LN-based products have been developed enhance permeation bioactive compounds skin, obtaining interesting results in both pharmaceutical cosmetic fields. Therefore, this review aims analyze scientific literature regarding use LNs treat major (psoriasis, wound healing, atopic dermatitis, acne) esthetic defects (wrinkles cellulite). Furthermore, attention has paid transdermal application (topical formulations, patches, microneedles), being new topic recent years.
Language: Английский
Citations
0
Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)
Published: Feb. 1, 2025
ABSTRACT The objective of a regenerative medicine is to repair, restore, and regenerate tissues organs that occurred due injury or defect disease. Additionally, the purpose reverse aging process body by utilizing body's innate healing ability. There still significant venture needs be directed for advancement in arena medicine, which makes use products derived from cell therapy as well biomedical. Stem cells growth factors are primary components medicine; hence, novel drug delivering systems now being studied augment transport active pharmaceuticals. Lipid‐based complexed with therapeutics suited site‐specific controlled release. Lipids biocompatible available various sources molecular weights self‐assemble into forms hydrophilic hydrophobic parts. By enhancing plasma membrane fluidity, excipients such non‐ionic surfactants, fatty acids, glycerides increase permeability. Liposomes, nanoparticles, nano‐emulsions, micelles nano‐lipid carriers can improve bioavailability both lipophilic medicines. lipoidal‐polymeric had emerged promising multifaceted application cytocompatibility, ecofriendly, ability encapsulate variety drugs. Further, treatment biomedical tissue engineering, rapidly developing discipline. Furthermore, similar vein, delivery technologies combined stem promote engraftment, differentiation, survival. Hence colloidal carrier has impending versatile applications. Therefore, review offer an abridged information on significance technology offering confined ecosystem facilitates them thrive distinguish effective manner.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106688 - 106688
Published: Feb. 1, 2025
Language: Английский
Citations
0
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)
Published: March 5, 2025
Language: Английский
Citations
0
Journal of Liposome Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10
Published: July 15, 2024
Diabetic wound is one of the most challenge in healthcare, requiring innovative approaches to promote efficient healing. In recent years, lipid nanoparticle-based drug delivery systems have emerged as a promising strategy for enhancing diabetic repair by stimulating angiogenesis. These nanoparticles offer unique advantages, including improved stability, targeted delivery, and controlled release, making them formation new blood vessels. this review, we summarize emerging advances utilization deliver angiogenic agents angiogenesis wounds. Furthermore, provide an in-depth exploration key aspects, intricate design fabrication nanoparticles, their underlying mechanisms action, comprehensive overview preclinical studies. Moreover, address crucial considerations pertaining safety translation these into clinical practice. By synthesizing analyzing available knowledge, our review offers valuable insights future prospects challenges associated with utilizing potential promoting robust process
Language: Английский
Citations
2
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8815 - 8830
Published: Aug. 1, 2024
Diabetic wounds pose a significant challenge in modern healthcare due to their chronic and complex nature, often resulting delayed healing, infections, and, severe cases, amputations. In recent years, nanotherapeutic approaches have emerged as promising strategies address the unique pathophysiological characteristics of diabetic wounds. This review paper provides comprehensive overview latest advancements nanotherapeutics for wound treatment. We discuss various nanomaterials delivery systems employed these emerging therapies. Furthermore, we explore integration biomaterials enhance efficacy interventions. By examining current state-of-the-art research, challenges, prospects, this aims offer valuable insights researchers, clinicians, professionals working field care.
Language: Английский
Citations
2
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124484 - 124484
Published: July 20, 2024
Language: Английский
Citations
1
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, antiviral properties, particularly in vitro or silico; however, their vivo applications are hindered by inadequate absorption distribution the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) nanostructured carriers (NLC) has significant advancements represents a viable approach to improve bioavailability through different administration routes.
Language: Английский
Citations
1
BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4056 - 4082
Published: July 25, 2024
Language: Английский
Citations
0