Optical ptychography for biomedical imaging: recent progress and future directions [Invited] DOI Creative Commons
Tianbo Wang, Shaowei Jiang, Pengming Song

et al.

Biomedical Optics Express, Journal Year: 2022, Volume and Issue: 14(2), P. 489 - 489

Published: Dec. 15, 2022

Ptychography is an enabling microscopy technique for both fundamental and applied sciences. In the past decade, it has become indispensable imaging tool in most X-ray synchrotrons national laboratories worldwide. However, ptychography's limited resolution throughput visible light regime have prevented its wide adoption biomedical research. Recent developments this resolved these issues offer turnkey solutions high-throughput optical with minimum hardware modifications. The demonstrated now greater than that of a high-end whole slide scanner. review, we discuss basic principle ptychography summarize main milestones development. Different ptychographic implementations are categorized into four groups based on their lensless/lens-based configurations coded-illumination/coded-detection operations. We also highlight related applications, including digital pathology, drug screening, urinalysis, blood analysis, cytometric rare cell culture monitoring, tissue 2D 3D, polarimetric among others. imaging, currently early stages, will continue to improve performance expand applications. conclude review article by pointing out several directions future

Language: Английский

Single-shot deterministic complex amplitude imaging with a single-layer metalens DOI Creative Commons
Liu Li, Shuai Wang, Feng Zhao

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 5, 2024

Conventional imaging systems can only capture light intensity. Meanwhile, the lost phase information may be critical for a variety of applications such as label-free microscopy and optical metrology. Existing retrieval techniques typically require bulky setup, multiframe measurements, or prior target scene. Here, we proposed an extremely compact system complex amplitude imaging, leveraging extreme versatility single-layer metalens to generate spatially multiplexed polarization phase–shifted point spread functions. Combining with camera, simultaneously record four shearing interference patterns along both in-plane directions, thus allowing deterministic reconstruction field in single shot. Using incoherent light-emitting diode illumination, experimentally demonstrated speckle-noise–free static moving objects tailored magnification ratio view. The miniaturized robust open door portable devices point-of-care applications.

Language: Английский

Citations

32
Lens-free on-chip 3D microscopy based on wavelength-scanning Fourier ptychographic diffraction tomography DOI Creative Commons
Xuejuan Wu, Ning Zhou, Yang Chen

et al.

Light Science & Applications, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 5, 2024

Language: Английский

Citations

21
Neural-field-assisted transport-of-intensity phase microscopy: partially coherent quantitative phase imaging under unknown defocus distance DOI
Yanbo Jin, Linpeng Lu, Shun Zhou

et al.

Photonics Research, Journal Year: 2024, Volume and Issue: 12(7), P. 1494 - 1494

Published: May 9, 2024

The transport-of-intensity equation (TIE) enables quantitative phase imaging (QPI) under partially coherent illumination by measuring the through-focus intensities combined with a linearized inverse reconstruction algorithm. However, overcoming its sensitivity to settings remains challenging problem because of difficulty in tuning optical parameters system accurately and instability long-time measurements. To address these limitations, we propose experimentally validate solution called neural-field-assisted microscopy (NFTPM) introducing tunable defocus parameter into neural field. Without weak object approximation, NFTPM incorporates physical prior image formation constrain field learns continuous representation without need for training. Simulation experimental results HeLa cells demonstrate that can achieve accurate, QPI unknown distances, providing new possibilities extending applications live cell biology.

Language: Английский

Citations

19
Metrology of metasurfaces: optical properties DOI Creative Commons
Nicolas Kossowski,

Yanel Tahmi,

Amir Loucif

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 31, 2025

Optical Metasurfaces (MSs), a new class of planar optical elements, are profoundly disrupting the field design, notably due to their compactness, multi-functionalities, and device integrability. Relying on nanofabrication processes closely akin semiconductor industry, metasurface technology could benefit from cost-effective potentially large-scale fabrication techniques forthwith. However, manufacturing metasurfaces with higher levels complexity in foundries, assembling them production lines, still requires comprehensive metrology solutions, associated established standardized measurements, that can validate functionalities during after integration into system. Here, we first review existing previously used for inspection, including intensity, polarization, quantitative phase ptychographic imaging. We finally discuss perspectives exciting trends designs, trying identify disruptive roles they play endowing next-generation systems improved performance enhanced measurement functionalities.

Language: Английский

Citations

2
Tunable meta-device for large depth of field quantitative phase imaging DOI Creative Commons

Jialuo Cheng,

Zihan Geng,

Yin Zhou

et al.

Nanophotonics, Journal Year: 2025, Volume and Issue: 14(8), P. 1249 - 1256

Published: Feb. 15, 2025

Abstract In traditional optical imaging, image sensors only record intensity information, and phase information of transparent samples such as cells semiconductor materials is hard to obtain. Quantitative imaging techniques are crucial for obtaining detailed but current methods often require complex interferometric setups or mechanical adjustments, limiting their practical applicability. Here, we proposed a novel meta-device integrating PB phase-based meta-lens, refractive lens, an electronically tunable lens with polarization camera capture multiple defocused images simultaneously the transport equation-based retrieval algorithm. By leveraging distinct focus lengths left-circularly polarized right-circularly light, eliminates need shots movements. Our approach enables rapid, precise, quantitative at different depths. The experiment shows accuracy our 98.47 % 2.52 mm depth range objects that can be retrieved, making it highly suitable dynamic depth-varying samples, in solution.

Language: Английский

Citations

2
Non-polynomial framework for stress and strain response of the FG-GPLRC disk using three-dimensional refined higher-order theory DOI
M.S.H. Al-Furjan, Mostafa Habibi, Aria Ghabussi

et al.

Engineering Structures, Journal Year: 2020, Volume and Issue: 228, P. 111496 - 111496

Published: Nov. 30, 2020

Language: Английский

Citations

138
Combined effect of using porous media and nano-particle on melting performance of PCM filled enclosure with triangular double fins DOI Creative Commons
Shubo Chen, S. Saleem, Mohammed N. Alghamdi

et al.

Case Studies in Thermal Engineering, Journal Year: 2021, Volume and Issue: 25, P. 100939 - 100939

Published: March 18, 2021

In the present study, a vertically oriented rectangular-shaped enclosure with triangular shaped double fins filled PCM was considered as Latent Thermal Energy Storage (LTES) system. Nine different cases including one pure PCM, three nano-PCM (having volume fractions), two porous-PCM porosity values) and nano/porous were to conduct investigation. The material employed for investigations lauric acid. copper made porous media assumed have values of 98% 95%. Al2O3 nano-particles fractions 1%, 2% 4% combined Lauric acid nano-PCM. results presented that nanoparticles 1% could improve melting performance. However, case nanoparticle fraction deteriorated individual usage best related resulted in about 184s time-saving. It found significantly performance; however, adding media, regardless deteriorates performance enclosure.

Language: Английский

Citations

100
A novel design of all optical half-subtractor using a square lattice photonic crystals DOI
Fariborz Parandin,

Reza Kamarian,

Mohamadreza Jomour

et al.

Optical and Quantum Electronics, Journal Year: 2021, Volume and Issue: 53(2)

Published: Feb. 1, 2021

Language: Английский

Citations

83
Polymeric membranes on base of PolyMethyl methacrylate for air separation: a review DOI Creative Commons
Ehsan Kianfar, Viet Cao

Journal of Materials Research and Technology, Journal Year: 2020, Volume and Issue: 10, P. 1437 - 1461

Published: Dec. 29, 2020

Widespread applications of O2 and N2 especially in the oil, gas, petrochemical industries have put air separation process into center attention among researchers artisans more than before. Hence, this paper, by use polymeric membrane has investigated. Poly methyl methacrylate (PM MA) selected as a base polymer because its good performance. The technology is attractive due to low energy consumption, relatively volume equipment, well ease transportation compared other conventional methods such Cryogenic distillation Pressure Swing Adsorption. Due properties polymer, chemical resistance stability, dense structure, result, it shows molecular sizing gases with very small diameter. types made from are discussed article.

Language: Английский

Citations

77
Smart computational light microscopes (SCLMs) of smart computational imaging laboratory (SCILab) DOI Creative Commons
Yao Fan, Jiaji Li, Linpeng Lu

et al.

PhotoniX, Journal Year: 2021, Volume and Issue: 2(1)

Published: Sept. 3, 2021

Abstract Computational microscopy, as a subfield of computational imaging, combines optical manipulation and image algorithmic reconstruction to recover multi-dimensional microscopic images or information micro-objects. In recent years, the revolution in light-emitting diodes (LEDs), low-cost consumer sensors, modern digital computers, smartphones provide fertile opportunities for rapid development microscopy. Consequently, diverse forms microscopy have been invented, including holographic (DHM), transport intensity equation (TIE), differential phase contrast (DPC) lens-free on-chip holography, Fourier ptychographic (FPM). These techniques not only high-resolution, label-free, quantitative imaging capability but also decipher new advanced biomedical research industrial applications. Nevertheless, most are still at an early stage “proof concept” prototype” (based on commercially available microscope platforms). Translating those concepts stand-alone instruments practical use is essential step promotion adoption by wider bio-medicine, industry, education community. this paper, we present four smart light microscopes (SCLMs) developed our laboratory, i.e., laboratory (SCILab) Nanjing University Science Technology (NJUST), China. empowered techniques, TIE, DPC, lensless FPM, which enables multi-modal contrast-enhanced observations unstained specimens, can their three-dimensional profiles quantitatively. We introduce basic principles, hardware configurations, algorithms, software design, quantify performance, illustrate typical applications cell analysis, medical diagnosis, microlens characterization.

Language: Английский

Citations

74