Organic & Biomolecular Chemistry,
Journal Year:
2025,
Volume and Issue:
23(10), P. 2281 - 2301
Published: Jan. 1, 2025
Imidazole-based
chemicals
exhibit
significant
potential
in
various
scientific
fields,
mainly
the
chemical
and
pharmaceutical
sciences.
The
imidazole
ring
is
a
five-membered
aromatic
heterocycle
found
several
natural
synthetic
substances.
Its
distinctive
structural
property,
which
includes
desirable
electron-rich
characteristic,
allows
derivatives
to
readily
bond
with
wide
range
of
anions,
cations,
neutral
organic
molecules.
This
review
aims
assemble
sensing
qualities
most
recently
reported
analyse
their
as
sensors.
Among
all
other
ions,
fluoride
primarily
targeted
for
this
context,
because
ions
have
garnered
lot
attention
recent
decades
due
physiochemical
properties
essential
roles
many
biological,
chemical,
pharmaceutical,
environmental
processes.
Fluoride
ion
detection
broad
field,
fluorescent
probes
are
continuously
introduced
bind
aqueous
media.
A
few
reviews
been
published,
emphasizing
macrocycle
cages,
nanomaterial
probes,
bio-material
sensors,
large
molecule
chemosensors
F-
detection.
special
focusing
solely
on
by
imidazole-based
moiety
has
not
yet
addressed.
Imidazole
compounds
surged
prominence
over
last
years,
making
them
particularly
developing
efficient,
sensitive,
selective
methods.
present
concisely
represents
contribution
variety
fluorophores
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: March 9, 2025
ABSTRACT
This
study
introduces
a
novel
organic
fluorescent
chemosensor,
designated
as
imidazole
4‐(1‐(4‐(5‐(4‐(
tert
‐butyl)phenyl)‐1,3,4‐oxadiazol‐2‐yl)phenyl)‐1
H
‐phenanthro[9,10‐
d
]imidazol‐2‐yl)‐N,N‐diphenylaniline
(
TIMTB
).
Engineered
specifically
for
detecting
aluminium
(Al
3+
)
and
iron
(Fe
ions,
demonstrates
exceptional
selectivity,
rapid
response
times,
efficacy
in
complex
matrices
such
biological
fluids
environmental
samples.
Comprehensive
evaluations
through
UV
absorption,
fluorescence
spectroscopy,
pH‐dependent
studies
confirm
's
high
sensitivity
selectivity
towards
Al
Fe
.
Further,
the
was
supported
by
Density
Functional
Theory
(DFT)
studies.
,
synthesized
with
an
imidazole‐oxadiazole
core,
exhibited
significantly
low
cytotoxicity
(14
±
0.15
μM).
In
aqueous
ethanol
medium,
probe
achieved
notably
detection
limits
of
2
nM
2.19
μM
Minimal
observed
both
in‐vitro
(MDA‐MB‐231
cells)
in‐vivo
(zebrafish,
Danio
rerio
studies,
paving
way
its
application
tracing
intracellular
ions
zebrafish
embryos.
robust
performance
underscores
potential
invaluable
tool
monitoring
biomedical
applications.
New Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
study
presents
TIMF,
a
novel
chemosensor
for
Al
3+
and
Fe
detection.
TIMF
displays
high
selectivity,
rapid
response,
low
cytotoxicity.
Spectroscopic
DFT
studies
confirm
its
sensitivity,
with
successful
in
vitro
vivo
applications.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: March 16, 2025
ABSTRACT
In
this
work,
a
novel
fluorescent
chemosensor
3‐(2‐(2‐(4‐(diphenylamino)phenyl)‐4,5‐diphenyl‐1
H
‐imidazol‐1‐yl)thiazol‐4‐yl)‐2
‐chromen‐2‐one
(
TCCM
)
was
effectively
synthesized
and
characterized
through
NMR
Mass
spectrum.
An
approach
towards
the
recognition
of
Cu
2+
Co
ions
using
turn‐off
fluorescence
technique
developed.
The
also
exhibited
colorimetric
fluorometric
sensing
behaviour
with
visible
response
to
trifluoroacetic
acid
(TFA).
Upon
addition
TFA
,
new
peak
formation
at
500
nm
in
absorption
spectra
along
colour
change
from
colourless
brown.
addition,
it
exhibits
high
selectivity
limit
detection
4.2
3.9
μM,
respectively.
It
discovered
that
sensor
quite
selective
for
had
lot
competing
ions.
Further,
studies
were
supported
by
DFT
analysis
NBO
studies.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(4)
Published: April 1, 2025
ABSTRACT
Malononitrile,
modified
hydrazine,
and
quinoline
aldehyde
were
combined
in
a
one‐pot
reaction
under
microwave
irradiation
to
create
the
medicinally
significant
family
of
heterocyclic
scaffolds,
quinoline,
coumarin,
thiazole,
pyrazole
4‐carbonitrile
derivatives
with
help
green
solvent
as
water.
WELPSA
(water
extract
lemon
peel‐soaked
ash)
is
used
speed
up
solvent‐free
environment,
according
more
environmentally
friendly
protocols.
This
methodology
offers
several
advantages
like
short
duration,
synthesis,
high
yield,
no
need
for
chromatographic
techniques,
catalyst
recyclability
five
cycles,
so
on.
Synthesized
evaluated
anticancer
potential
against
lung
(A549)
breast
cancer
cell
lines.
Among
tested
compounds,
4i
4j
exhibited
remarkable
activities.
Further
investigations
using
Annexin
V
staining
flow
cytometry
revealed
that
both
compounds
effectively
induced
apoptosis
A549
cells.
Compound
was
subjected
molecular
docking
dynamic
studies
understand
basis
their
activity,
which
demonstrated
strong
interaction
target
protein
1m17,
providing
insights
into
its
mechanism
action.
These
findings
highlight
promising
candidates
drug
development.
