Advanced Drug Delivery Systems for Topical Insulin in Diabetic Wound Healing DOI

Sheida Barkhordari,

Farangis Shahi,

Hossein Ali Khonakdar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Diabetes mellitus is a chronic condition characterized by impaired insulin production or utilization, leading to serious complications such as diabetic foot ulcers (DFUs). DFUs are wounds with high levels of inflammatory cytokines, arterial occlusion, and persistent infection, often resulting in significant morbidity. Traditional treatment methods, including debridement, offloading, infection control, have shown limited success, prompting the exploration novel therapeutic strategies. Insulin, known for its role glucose metabolism, also possesses wound‐healing properties promoting cell proliferation, protein synthesis, modulating inflammation. However, systemic administration not ideal due hypoglycemia risks difficulties achieving concentrations at wound sites. This review focuses on advanced drug delivery systems topical application dressings. Various platforms, hydrogels, nanoparticles, liposomes, microemulsions been developed optimize bioavailability, protect it from degradation, ensure controlled release. These aim enhance management addressing multifactorial nature healing patients. The provides comprehensive overview current advancements, evaluates efficacy these preclinical clinical studies, discusses challenges future perspectives this field. By highlighting potential innovative approaches, underscores promise improving patient outcomes.

Language: Английский

The Role of Lightweight AI Models in Supporting a Sustainable Transition to Renewable Energy: A Systematic Review DOI Creative Commons
Tymoteusz Miller, Irmina Durlik, Ewelina Kostecka

et al.

Energies, Journal Year: 2025, Volume and Issue: 18(5), P. 1192 - 1192

Published: Feb. 28, 2025

The transition from fossil fuels to renewable energy (RE) sources is an essential step in mitigating climate change and ensuring environmental sustainability. However, large-scale deployment of renewables accompanied by new challenges, including the growing demand for rare-earth elements, need recycling end-of-life equipment, rising footprint digital tools—particularly artificial intelligence (AI) models. This systematic review, following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines, explores how lightweight, distilled AI models can alleviate computational burdens while supporting critical applications systems. We examined empirical conceptual studies published between 2010 2024 that address energy, circular economy paradigm, model distillation low-energy techniques. Our findings indicate adopting significantly reduce consumption data processing, enhance grid optimization, support sustainable resource management across lifecycle infrastructures. review concludes highlighting opportunities challenges policymakers, researchers, industry stakeholders aiming integrate principles into RE strategies, emphasizing urgent collaborative solutions incentivized policies encourage low-footprint innovation.

Language: Английский

Citations

1
Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications DOI

Farangis Shahi,

Hana Afshar,

Elmuez A. Dawi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

Citations

4
Pre-twisted carbon fibers reinforced polymer composites and the unique clockwise and counterclockwise torsion behaviors DOI
Hao Yu, Jiajia Dai, Chi Zhang

et al.

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 120104 - 120104

Published: Feb. 1, 2025

Language: Английский

Citations

0
Recent Advances in Biomedical Applications of MXene‐Integrated Electrospun Fibers: A Review DOI
Ali Hamzehlouy,

Sara Zarei,

Razhan Salah Othman

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT The integration of MXenes into electrospun fibers represents a significant leap forward in advancing biomedical applications. This review delves the synergistic combination and fibers, highlighting their multifaceted capabilities tissue engineering, drug delivery, antimicrobial activity, cancer therapy, biosensing. Exceptional properties MXene, including electrical conductivity, hydrophilicity, mechanical robustness, surface tunability, offer unique advantages when incorporated nanofibrous scaffolds. By enhancing strength, promoting cellular interactions, enabling targeted therapeutic functions, MXene‐based demonstrate immense potential addressing critical challenges biomedicine. provides comprehensive overview recent advances MXene synthesis, incorporation matrices, applications, while also identifying future directions this emerging field.

Language: Английский

Citations

0
Recent Advances in Multifunctional Naturally Derived Bioadhesives for Tissue Engineering and Wound Management DOI
Aliakbar Jafari, Ahmed Al‐Ostaz, Sasan Nouranian

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT Recent advancements in naturally derived bioadhesives have transformed their application across diverse medical fields, including tissue engineering, wound management, and surgery. This review focuses on the innovative development multifunctional nature of these bioadhesives, particularly emphasizing role enhancing adhesion performance wet environments optimizing mechanical properties for use dynamic tissues. Key areas covered include chemical physical mechanisms adhesion, incorporation multi‐adhesion strategies that combine covalent non‐covalent bonding, bioinspired designs mimicking natural adhesives such as those barnacles mussels. Additionally, discusses emerging applications regeneration musculoskeletal, cardiac, neural, ocular tissues, highlighting potential bioadhesive‐based therapies complex biological settings. Despite substantial progress, challenges scaling lab‐based innovations clinical overcoming environmental constraints remain critical. Ongoing research bioadhesive technologies aims to bridge gaps, promising significant improvements tailored therapeutic needs.

Language: Английский

Citations

3
Emerging Applications of Smart Hydrogel Nanocomposites in 3D Printing DOI
Mohammad Heidari,

Farangis Shahi,

Hana Afshar

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review provides a comprehensive overview of the emerging applications stimuli‐responsive hydrogels in 3D printing, emphasizing their transformative potential creating adaptive and multifunctional structures. Stimuli‐responsive hydrogels, including magneto‐, thermo‐, pH‐, moisture‐, solvent‐, photo‐responsive varieties, have gained significant attention due to ability undergo dynamic changes response specific environmental stimuli. The begins by exploring fundamental characteristics fabrication methods used additive manufacturing, highlighting exceptional adaptability programmability. It then delves into various across diverse fields, soft robotics, tissue engineering, drug delivery systems, wearable electronics, food technology, electromagnetic interference shielding, anti‐counterfeiting technologies. By integrating latest advancements printing techniques, this aims offer insights how are enabling development innovative, intelligent, environmentally responsive systems. future perspectives section discusses challenges opportunities for advancing use suggesting directions research that could push boundaries functional materials programmable

Language: Английский

Citations

3
Recent Advances in Potential Biomedical Applications of MXene‐Based Hydrogels DOI
Ali Hamzehlouy, Masoud Tavakoli Dare,

Farangis Shahi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Nov. 29, 2024

ABSTRACT MXene‐based hydrogels represent a significant advancement in biomedical material science, leveraging the unique properties of 2D MXenes and versatile functionality hydrogels. This review discusses recent developments integration into hydrogel matrices, focusing on their applications such as wound healing, drug delivery, antimicrobial activity, tissue engineering, biosensing. MXenes, due to remarkable electrical conductivity, mechanical robustness, tunable surface chemistry, enhance properties, responsiveness environmental stimuli. Specifically, have shown great promise accelerating healing through photothermal effects, delivering drugs controlled manner, serving antibacterial agents. Their also enables targeted cancer therapies, including chemodynamic facilitated by high conductivity properties. Despite promising progress, challenges ensuring biocompatibility optimizing synthesis for large‐scale production remain. aims provide comprehensive overview current state applications, highlighting ongoing advancements potential future directions these multifunctional materials.

Language: Английский

Citations

2
Advanced Drug Delivery Systems for Topical Insulin in Diabetic Wound Healing DOI

Sheida Barkhordari,

Farangis Shahi,

Hossein Ali Khonakdar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Diabetes mellitus is a chronic condition characterized by impaired insulin production or utilization, leading to serious complications such as diabetic foot ulcers (DFUs). DFUs are wounds with high levels of inflammatory cytokines, arterial occlusion, and persistent infection, often resulting in significant morbidity. Traditional treatment methods, including debridement, offloading, infection control, have shown limited success, prompting the exploration novel therapeutic strategies. Insulin, known for its role glucose metabolism, also possesses wound‐healing properties promoting cell proliferation, protein synthesis, modulating inflammation. However, systemic administration not ideal due hypoglycemia risks difficulties achieving concentrations at wound sites. This review focuses on advanced drug delivery systems topical application dressings. Various platforms, hydrogels, nanoparticles, liposomes, microemulsions been developed optimize bioavailability, protect it from degradation, ensure controlled release. These aim enhance management addressing multifactorial nature healing patients. The provides comprehensive overview current advancements, evaluates efficacy these preclinical clinical studies, discusses challenges future perspectives this field. By highlighting potential innovative approaches, underscores promise improving patient outcomes.

Language: Английский

Citations

1