Theranostics,
Journal Year:
2021,
Volume and Issue:
12(2), P. 542 - 557
Published: Dec. 15, 2021
Osteoarthritis
(OA)
is
one
of
the
rapidly
growing
disability-associated
conditions
with
population
aging
worldwide.
There
a
pressing
need
for
precise
diagnosis
and
timely
intervention
OA
in
early
stage.
Current
clinical
imaging
modalities,
including
pain
radiography,
magnetic
resonance
imaging,
ultrasound,
optical
coherent
tomography,
are
limited
to
provide
structural
changes
when
damage
has
been
established
or
advanced.
It
prompts
further
endeavors
search
novel
functional
molecular
which
potentially
enables
OA.
A
hybrid
modality
based
on
photothermal
effects,
photoacoustic
drawn
wide
attention
recent
years
seen
variety
biomedical
applications,
due
its
great
performance
yielding
high-contrast
high-resolution
images
from
structure
function,
tissue
down
levels,
animals
human
subjects.
Photoacoustic
witnessed
gratifying
potentials
preliminary
effects
diagnosis.
Regarding
treatment
OA,
photothermal-triggered
therapy
exhibited
attractions
enhanced
therapeutic
outcomes.
In
this
narrative
review,
we
will
discuss
monitoring
at
different
stages.
Structural,
functional,
parameter
associated
joints
captured
by
photoacoustics
be
summarized,
forming
perspective
review.
Photothermal
applications
related
also
discussed
herein.
Lastly,
relevant
potential
solutions
extend
deeper
situations
have
proposed.
Although
some
aspects
may
not
covered,
mini
review
provides
better
understanding
exciting
innovations
effects.
inspire
more
explorations
field
towards
earlier
theranostics
Abstract
Over
the
past
few
decades,
number
of
patients
with
neurological
diseases
has
increased
significantly,
posing
huge
challenges
and
opportunities
for
development
brain
imaging
technology.
As
a
hybrid
method
combining
optical
excitation
acoustic
detection
techniques,
photoacoustic
tomography
(PAT),
experienced
rapid
development,
due
to
high
contrast
spatial
resolution
at
depth
inside
tissues.
With
lasers,
ultrasonic
detectors,
data
computations,
PAT
been
widely
applied
diagnosis
oncology,
dermatosis,
etc.
However,
energy
light
ultrasound
would
be
greatly
attenuated
while
penetrating
skull,
reflection,
absorption,
scattering
effects,
resulting
in
limited
application
imaging.
In
this
review,
we
summarized
achievements
its
including
glioma,
stroke,
traumatic
injury,
Alzheimer's
disease,
epilepsy,
Parkinson's
disease.
Moreover,
various
systems
multi‐modality
are
introduced
potential
clinical
applications.
Finally,
current
limitations
further
also
discussed.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Sept. 10, 2024
Pandemics
like
COVID-19
have
highlighted
the
potential
of
Photoacoustic
imaging
(PAI)
for
Brain-Computer
Interface
(BCI)
communication
and
lung
diagnostics.
However,
PAI
struggles
with
clear
blood
vessels
in
areas
lungs
brain
due
to
their
cavity
structures.
This
paper
presents
a
simulation
model
analyze
generation
propagation
mechanism
within
phantom
tissues
artifacts,
focusing
on
evaluation
both
Anisotropic
diffusion
filtering
(ADF)
Non-local
mean
(NLM)
filtering,
which
significantly
reduce
noise
eliminate
artifacts
signify
pivotal
point
selecting
artifact-removal
algorithms
under
varying
conditions
light
distribution.
Experimental
validation
demonstrated
efficacy
our
technique,
elucidating
effect
source
uniformity
performance.
The
NLM
ADF
experimental
increased
peak
signal-to-noise
ratio
by
11.33%
18.1%,
respectively.
proposed
technique
adds
promising
dimension
BCI
is
an
accurate
solution
diagnosing
diseases.
Journal of Biophotonics,
Journal Year:
2023,
Volume and Issue:
16(7)
Published: April 13, 2023
Brain
hemorrhage,
specifically
intraventricular
hemorrhage
(IVH),
is
considered
one
of
the
primary
and
leading
causes
cerebral
anomalies
in
neonates.
Several
imaging
modalities
including
most
popular,
cranial
ultrasound,
are
not
capable
detecting
early
stage
IVHs.
Photoacoustic
(PAI)
exhibited
great
potential
for
studies
limited
to
small
animal
models,
but
these
models
comparable
neonatal
brain
morphology.
However,
detection
large
using
PAI
rare
due
complexity
cost
inducing
vivo.
Moreover,
vitro
unable
represent
physiology
environment
hemorrhagic
lesion.
Here,
we
proposed
a
pseudo
implementation
method
sheep
that
allows
us
mimic
different
lesions
ex
vivo
without
compromising
imaging.
This
approach
enables
true
evaluation
performance
hemorrhages
can
be
utilized
as
reference
optimize
system
Theranostics,
Journal Year:
2021,
Volume and Issue:
12(2), P. 542 - 557
Published: Dec. 15, 2021
Osteoarthritis
(OA)
is
one
of
the
rapidly
growing
disability-associated
conditions
with
population
aging
worldwide.
There
a
pressing
need
for
precise
diagnosis
and
timely
intervention
OA
in
early
stage.
Current
clinical
imaging
modalities,
including
pain
radiography,
magnetic
resonance
imaging,
ultrasound,
optical
coherent
tomography,
are
limited
to
provide
structural
changes
when
damage
has
been
established
or
advanced.
It
prompts
further
endeavors
search
novel
functional
molecular
which
potentially
enables
OA.
A
hybrid
modality
based
on
photothermal
effects,
photoacoustic
drawn
wide
attention
recent
years
seen
variety
biomedical
applications,
due
its
great
performance
yielding
high-contrast
high-resolution
images
from
structure
function,
tissue
down
levels,
animals
human
subjects.
Photoacoustic
witnessed
gratifying
potentials
preliminary
effects
diagnosis.
Regarding
treatment
OA,
photothermal-triggered
therapy
exhibited
attractions
enhanced
therapeutic
outcomes.
In
this
narrative
review,
we
will
discuss
monitoring
at
different
stages.
Structural,
functional,
parameter
associated
joints
captured
by
photoacoustics
be
summarized,
forming
perspective
review.
Photothermal
applications
related
also
discussed
herein.
Lastly,
relevant
potential
solutions
extend
deeper
situations
have
proposed.
Although
some
aspects
may
not
covered,
mini
review
provides
better
understanding
exciting
innovations
effects.
inspire
more
explorations
field
towards
earlier
theranostics
