Wavefront shaping: A versatile tool to conquer multiple scattering in multidisciplinary fields

The Innovation, Journal Year: 2022, Volume and Issue: 3(5), P. 100292 - 100292

Published: Aug. 2, 2022

Optical techniques offer a wide variety of applications as light-matter interactions provide extremely sensitive mechanisms to probe or treat target media. Most these implementations rely on the usage ballistic quasi-ballistic photons achieve high spatial resolution. However, inherent scattering nature light in biological tissues tissue-like media constitutes critical obstacle that has restricted penetration depth non-scattered and hence limited implementation most optical for wider applications. In addition, components an system are usually designed manufactured fixed function performance. Recent advances wavefront shaping have demonstrated scattering- component-induced phase distortions can be compensated by optimizing input pattern through iteration conjugating transmission matrix medium. This offers unprecedented opportunities many controllable delivery detection at depths dynamically configurable functionalities using substitute conventional components. this article, recent progress multidisciplinary fields is reviewed, from focusing imaging with media, functionalized devices, modulation mode coupling, nonlinearity multimode fiber fiber-based Apart insights into underlying principles implementations, practical limitations roadmap future development discussed depth. Looking back looking forward, it believed holds bright will open new avenues noninvasive minimally invasive arbitrary control inside deep tissues. The degree freedom multiple also develop novel devices based single medium (generic customized) outperform traditional

Language: Английский

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Targeted and responsive biomaterials in osteoarthritis

Theranostics, Journal Year: 2023, Volume and Issue: 13(3), P. 931 - 954

Published: Jan. 1, 2023

Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions tissue lesions.The non-vascular environment dense matrix in the joints tend to block drug penetration, resulting low bioavailability.There desire develop safer more effective OA therapies meet challenges an aging world population future.Biomaterials have achieved satisfactory results improving targeting, prolonging duration action, achieving precision therapy.This article reviews current basic understanding pathological mechanisms clinical treatment dilemmas OA, summarizes discusses advances for different kinds targeted responsive biomaterials seeking provide new perspectives OA.Subsequently, limitations translation biosafety are analyzed guide development future therapeutic strategies OA.As need medicine rises over time, emerging multifunctional based on targeting controlled release will become irreplaceable part management.

Language: Английский

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Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early‐Stage Glioblastoma Based on a Biomimetic Nanoplatform

Advanced Science, Journal Year: 2023, Volume and Issue: 10(19)

Published: May 7, 2023

Abstract Early diagnosis can effectively improve the survival of glioblastoma multiforme (GBM). A specific imaging technique that is simultaneously deep penetrating and sensitive to small tissue changes desired identify GBM. Due its excellent features in signal contrast, detection sensitivity, none or little attenuation tissue, magnetic particle (MPI) possesses great potential cancer diagnosis, especially when modality equipped with specifically targeted nanoprobes. However, gliomas are small, blood–brain barrier (BBB) complete prevents nanoprobes from entering brain, which negates theranostic effect. This study proposes a biomimetic nanoplatform assist MPI tracers breaking through BBB then demonstrate Afterward, photothermal therapy immune regulation show an therapeutic effect on It experimentally confirmed does not decay depth shows sensitivity for thousands‐cells. Only animals conducted this due limitations current commercial scanner, however, research theoretically enables large animal human studies, encourages promising pathway toward noninvasive early‐stage GBM clinics.

Language: Английский

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Cartilage-inspired hydrogel lubrication strategy

The Innovation, Journal Year: 2022, Volume and Issue: 3(5), P. 100275 - 100275

Published: June 23, 2022

Language: Английский

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Remodeling of the pro-inflammatory microenvironment in osteoarthritis via hydrogel-based photothermal therapy

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(2)

Published: Feb. 20, 2024

Language: Английский

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Photoacoustic Imaging in Inflammatory Orthopedic Diseases: Progress toward Precise Diagnostics and Predictive Regulation

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract With the intensification of aging issues, inflammatory orthopedic diseases almost occur in majority elderly people, which is becoming increasingly severe. Photoacoustic imaging (PAI) a non‐invasive visualization technique for clear diagnosis inflammation areas through detecting acoustic signals generated by laser irradiation. The combination “light input” and “acoustic output” provides unprecedented scalability as well high penetration depth resolution. This new technology can also present more anatomical information feedback status activity diseases. Especially imaging, this effectively supplement current clinical methods diagnosis, staging, monitoring pathophysiological processes. rapid development these technologies, goals precise predictive regulation, ultimately personalized treatment strategies are realistic. Herein, article introduces various inflammations related applications. It covers types PA nanoprobes their research progress inflammation, potential applications PAI aspects. review discusses recent researches emerging translational prospects future challenges transformation.

Language: Английский

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Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Lenvatinib, endorse as a first-line targeted therapy, has demonstrated efficacy in extending the survival span of individuals afflicted with advanced Hepatocellular carcinoma (HCC). However, its therapeutic effect wears off time, which is ascribed to cancer cell's tendency evade and tamper usual modes action, severely limiting clinical use. This study devises an innovative modality involving synergistic co-delivery FePt nanoparticles (NPs) Lenvatinib via poly lactic-co-glycolic acid (PLGA) NPs encase HCC cell membranes (Len/FePt@CMP NPs). The investigation explores mechanism through induces ferroptosis HCC, notably by dampening glutathione peroxidase 4 (GPX4) inhibition fibroblast growth factor receptor 4. are engineered enhance apoptosis for treatment. Concurrently, incorporation membrane facilitates accumulation at tumor site, leveraging mechanisms immune evasion homologous targeting. enhances ferroptosis/apoptosis treatment efficacy, triggeres Len/FePt@CMP NPs, convincingly both vitro vivo. proposed approach potential redefine paradigms overcoming mono-therapeutic limitations current treatments, showcasing improved comprehensive strategy.

Language: Английский

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NIR-IIb Fluorescence Molecular Tomography of Glioblastomas Based on Heterogeneous Mouse Models and Adaptive Projection Match Pursuit Method

IEEE Transactions on Biomedical Engineering, Journal Year: 2023, Volume and Issue: 70(8), P. 2258 - 2269

Published: April 24, 2023

Fluorescence molecular tomography (FMT) using fluorescence of the second near-infrared window (NIR-II) has been proved to outperform conventional FMT first (NIR-I). However, it was still a challenge achieve satisfactory reconstructed light source NIR-II as NIR-IIa (1300-1400 nm) in spectrum used previous study suffering from prominent absorption and scattering tissue.A novel NIR-IIb (1500-1700 method proposed applied reconstruction glioblastomas animal models. Optical parameters that describe effect different tissue on photons were calculated construct propagation model form forward model. Besides, adaptive projection matching pursuit (APMP) further adopted accurately solve inverse problem. Location error Dice coefficient evaluate accuracy reconstruction. Simulation experiments single-source dual-source vivo conducted source.Both simulation demonstrated achieved reduced location improved shape similarity compared with NIR-IIa. orthotopic mouse models 0.65 mm 0.56, which both outperformed NIR-IIa.The results better performance for positioning recovery.The inspiring this demonstrate effectiveness advantages precise tumor positioning.

Language: Английский

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Macrophage Membrane‐Biomimetic Multi‐Layered Nanoparticles Targeting Synovial Angiogenesis for Osteoarthritis Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Osteoarthritis (OA) is an inflammatory and progressive joint disease characterized by angiogenesis‐mediated sustained, chronic, low‐grade synovitis. Anti‐angiogenesis emerging as a strategy for attenuating OA progression, but often compromised poor targeted drug delivery immune clearance. Recent studies have identified macrophages formed “protective barrier” in the lining layer (LL) of synovium, which blocked communication cavity sublining (SL) synovium. Inspired natural mimicry, macrophage membrane‐camouflaged explored to avoid Based on single cell RNA sequencing, CD34 + synovial cells are “sentinel cells” synovium angiogenesis. Consequently, antibody‐modified membrane constructed target new Hence, biomimetic multi‐layered nanoparticle (NP) developed that incorporates axitinib‐loaded poly(lactic‐co‐glycolic) acid (PLGA) with antibody modified (Atb@NP@Raw@CD34) specifically deliver axitinib (Atb) SL sustain inhibiting angiogenesis without elimination. It found Atb@NP@Raw@CD34 can pass through “barrier”, targeting cells, continuously releasing Atb anti‐angiogenesis Furthermore, vivo data demonstrated attenuate degeneration In conclusion, local injection presents promising approach clinically impeding progression.

Language: Английский

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Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging

Photoacoustics, Journal Year: 2023, Volume and Issue: 32, P. 100530 - 100530

Published: July 15, 2023

Transdermal drug delivery (TDD) is less invasive and avoids first-pass metabolism, making it an attractive method for treating various diseases such as diabetes hypertension. However, current methods evaluating TDD systems lack in vivo descriptions of distribution the skin. In this study, we demonstrate capability Transient Triplet Differential (TTD) method, a non-invasive background-free photoacoustic imaging technique, accurately mapping different systems. Our findings show that TTD can provide high sensitivity specificity targeted extraction visualize 3D Furthermore, experiments confirmed potential clinical performance TDD. It's predictable be reliable approach offer valuable insights into research development.

Language: Английский

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