Photoacoustics, Journal Year: 2025, Volume and Issue: 42, P. 100703 - 100703
Published: Feb. 20, 2025
Language: Английский
Journal of Biomedical Optics, Journal Year: 2023, Volume and Issue: 28(08)
Published: Feb. 24, 2023
SignificanceCorticosteroids—commonly prescribed medications for skin diseases—inhibit the secretion of vasodilators, such as prostaglandin, thereby exerting anti-inflammatory action by constricting capillaries in dermis. The effectiveness corticosteroids is determined degree vasoconstriction followed whitening, namely, blanching effect. However, current method observing effect indirectly evaluates effects corticosteroids.AimIn this study, we employed optical-resolution photoacoustic (PA) microscopy (OR-PAM) to directly visualize blood vessels and quantitatively evaluate vasoconstriction.ApproachUsing OR-PAM, vascular density mice was monitored 60 min after performing each experimental procedure four groups, quantified. Volumetric PA data were segmented into papillary dermis, reticular hypodermis based on characteristics obtained through OR-PAM. vasoconstrictive layer quantified according dermatological treatment method.ResultsIn case corticosteroid topical application, observed (56.4 ± 10.9 % ) (45.1 4.71 For subcutaneous injection, constriction solely (49.5 9.35 In contrast, no vasoconstrictions with nonsteroidal application.ConclusionsOur results indicate that OR-PAM can monitor induced corticosteroids, validating OR-PAMs potential a practical evaluation tool predicting dermatology.
Language: Английский
Citations
12
Photonics, Journal Year: 2023, Volume and Issue: 10(8), P. 904 - 904
Published: Aug. 4, 2023
Photoacoustic imaging is a promising medical modality that enables the visualization of molecular functional and morphological information biological tissues. Its clinical potential has been widely investigated for assessing diagnosing various diseases. Currently, several research groups are developing photoacoustic systems translation from laboratory to clinic. In particular, integration into existing diagnostic ultrasound applications, such as cancer diagnosis, shown results. Additionally, recent explored application novel uses. this review paper, trials in both conventional applications summarized evaluated. current limitations future directions successful world discussed. The aim provide comprehensive overview advancements highlight its diagnosis treatment. It hoped will contribute development improved therapeutic approaches wide range diseases using imaging.
Language: Английский
Citations
12
Photoacoustics, Journal Year: 2023, Volume and Issue: 32, P. 100545 - 100545
Published: Aug. 1, 2023
Photoacoustic microscopy is advancing with research on utilizing ultraviolet and visible light. Dual-wavelength approaches are sought for observing DNA/RNA- vascular-related disorders. However, the availability of high numerical aperture lenses covering both wavelengths severely limited due to challenges such as chromatic aberration in optics. Herein, we present a groundbreaking proposal pioneering simulation study incorporating multilayer metalenses into ultraviolet-visible photoacoustic microscopy. The proposed metalens has thickness 1.4 µm 0.8. By arranging cylindrical hafnium oxide nanopillars, design an achromatic transmissive lens 266 532 nm wavelengths. achieves diffraction-limited focal spot, surpassing commercially available objective lenses. Through three-dimensional simulation, demonstrate high-resolution imaging superior endogenous contrast targets optical absorption bands. This will open new possibilities downsized multispectral clinical preclinical applications.
Language: Английский
Citations
12
Optics Letters, Journal Year: 2025, Volume and Issue: 50(3), P. 832 - 832
Published: Jan. 2, 2025
Nonlinear photoacoustic microscopy (PAM) usually requires dual-pulse excitation. Current approaches to realize laser train are indirect, mainly based on beam combinations. Here, we report a compact (∼5-cm-long cavity) source that directly outputs controllable nanosecond (∼34 ns) dual pulses, including the tunability of repetition rate (0-20 kHz), time delay (5-30 µs), and relative intensity ratio (20-500%), perfectly matching requirements nonlinear imaging in PAM. The single pulse energy is achieved up ∼95 µJ. We showcase PA performance with this typical Grüneisen-relaxation-based applications contrast enhanced by 8 dB. promising indicates can readily be applied PAMs, especially for portable applications.
Language: Английский
Citations
0
Photoacoustics, Journal Year: 2025, Volume and Issue: 42, P. 100703 - 100703
Published: Feb. 20, 2025
Language: Английский
Citations
0