Journal of Biophotonics,
Journal Year:
2024,
Volume and Issue:
17(7)
Published: May 2, 2024
Abstract
Vascular
diseases
are
a
leading
cause
of
death
and
disability
worldwide.
Despite
having
precursor
conditions
like
peripheral
arterial
disease
(PAD),
they
often
only
diagnosed
after
the
onset
stroke
or
heart
attack.
Low‐cost,
portable,
noninvasive,
point‐of‐care
(POC),
label‐free
assessment
deep
vascular
function
benefits
PAD
diagnosis,
especially
in
resource
poor
settings
world.
Doppler
ultrasound‐based
blood
flow
measurements
can
diagnose
PAD,
albeit
with
limited
sensitivity
specificity.
To
overcome
this,
here,
we
propose
first‐of‐its‐kind
dual‐modality
photoacoustic‐and‐ultrasound
(PAUS)
imaging
system
that
integrates
multiwavelength
pulsed
laser
diode
(PLD)
compact
ultrasound
data
acquisition
unit.
The
mesoscopic
depth
portable
PLD‐PAUS
was
validated
using
tissue
phantoms,
its
multispectral
photoacoustic
capabilities
were
an
atherosclerosis‐mimicking
phantom.
Furthermore,
demonstrated
high‐contrast
volumetric
vivo
rodent
abdominal
vasculature
quantified
vessel
reactivity
due
to
hypercapnia
stimulation.
multiparametric
functional
molecular
holds
promise
for
POC
applications.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1240 - 1240
Published: Sept. 24, 2024
Photoacoustic
imaging
(PAI)
is
an
emerging
noninvasive
and
label-free
method
for
capturing
the
vasculature,
hemodynamics,
physiological
responses
following
drug
delivery.
PAI
combines
advantages
of
optical
acoustic
to
provide
high-resolution
images
with
multiparametric
information.
In
recent
decades,
PAI's
abilities
have
been
used
determine
reactivity
after
administration
various
drugs.
This
study
investigates
photoacoustic
as
a
monitoring
delivery
by
observing
changes
in
vascular
system
oxygen
saturation
levels
across
biological
tissues.
addition,
we
discuss
studies
that
monitor
biodistribution
pharmacokinetics
exogenous
contrast
agents,
offering
contrast-enhanced
diseased
regions.
Finally,
demonstrate
crucial
role
understanding
mechanisms
treatment
processes.
Journal of Biomedical Optics,
Journal Year:
2023,
Volume and Issue:
28(10)
Published: Oct. 24, 2023
SignificanceSkin
capillaries
are
non-invasively
observable;
their
structure
and
blood
flow
can
reflect
tissue
systemic
conditions.
Quantitative
analysis
of
video-capillaroscopy
images
yields
novel
diagnostic
methods.
Because
the
capillary
is
heterogeneous,
analyzing
more
increase
evaluation
reliability.AimWe
developed
a
system
that
observe
quantify
numerous
verified
performance
on
human
skin.ApproachWe
portable
video-capillaroscope
with
spatial
resolution
higher
than
3.5
μm
wide
field
view
(7.4
mm
×
5.5
mm)
method
to
evaluate
numbers
areas
using
U-Net.
The
model
was
trained
tested
22
11
cropped
(2.4
1.9
obtained
from
participants,
respectively.
They
were
then
applied
7.2
5.3
four
participants.
Segmentation
results
compared
ground-truth
at
pixel
level
capillary-region
level.ResultsOver
1000
simultaneously
observed
proposed
system.
Although
pixel-level
segmentation
low
[intersection
over
union
(IoU)
=
24.5%],
number
area
could
be
estimated.
These
values
differed
among
participants
seven
sites,
they
changed
after
skin
barrier
destruction.ConclusionsThe
allows
for
observing
quantifying
simultaneously,
suggesting
its
potential
evaluating
NIR-II
window
(1000–1700
nm)
photoacoustic
contrast
agents
offer
deep
tissue
imaging
potential.
We
examined
whole-body
perfusion
kinematics
monitoring
in
by
dispersing
the
commercial
dye
IR-1048
using
a
transparent
ultrasound
transducer.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(1)
Published: July 18, 2024
Abstract
The
use
of
topical
corticosteroids
(TCs)
in
pediatric
patients
is
a
common
therapeutic
approach
for
various
dermatological
conditions.
However,
their
application
can
lead
to
spectrum
adverse
drug
reactions
(ADRs),
from
localized
skin
changes
systemic
effects.
Due
factors
such
as
thinner
skin,
enhanced
cutaneous
absorption,
and
developing
organ
systems,
populations
are
particularly
vulnerable
TCs-led
ADRs.
most
ADRs
associated
with
the
TCs
population
include
atrophy,
striae,
telangiectasia.
Other
less
allergic
contact
dermatitis,
perioral
effects
suppression
hypothalamic–pituitary–adrenal
(HPA)
axis,
etc.
To
minimize
possibility
unwanted
medication
reactions,
rational
safe
shall
be
promoted.
Clinical
Pharmacists
(CPs)
play
pivotal
role
ensuring
appropriate
utilization
patient
care.
CPs
collaborate
healthcare
practitioners
design
individualized
treatment
regimens
considering
age,
type,
medical
history.
They
also
educate
caregivers
on
proper
techniques,
therapy
duration,
potential
side
effects,
thereby
facilitating
better
adherence
outcomes.
research
specific
essential
provide
precise
insights
into
effectiveness
safety,
accounting
age-related
variations
long-term
consequences.
represent
valuable
tool
dermatology,
but
requires
careful
consideration
risks
benefits,
active
involvement
CPs,
regulatory
measures,
ongoing
optimize
outcomes
safety
patients.
Skin Pharmacology and Physiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 10
Published: Aug. 19, 2024
Introduction:
Skin-blanching
assay
has
been
established
as
a
surrogate
method
for
assessing
bioequivalence
of
topical
corticosteroids.
This
study
aimed
to
apply
the
skin-blanching
evaluate
test
desonide
cream
(T)
compared
with
reference
Desonide®
(R)
using
Chinese
skins.
Additionally,
pharmacokinetics
and
safety
profiles
were
also
assessed.
Methods:
By
detecting
degree
skin
blanching
under
different
dose
durations
in
pilot
dose-duration-response
study,
area
observed
effect-time
curve
(AUEC)
half
maximum
effect
(ED<sub>50</sub>)
was
calculated.
Based
on
this,
color
time
points
after
duration
ED<sub>50</sub>,
D1
(0.5
×
ED<sub>50</sub>),
D2
(2
ED<sub>50</sub>)
detected
pharmacodynamic
indicator
compare
between
creams.
Single-center,
single-dose,
randomized,
open-label,
two-cycle
crossover
pharmacokinetic
studies
designed
make
sure
exposure
tested
formulationswas
not
higher
than
that
formulations.
Subjects
experiencing
adverse
events
(AEs)
monitored
utilized
analysis.
Results:
These
involved
12
subjects
100
study.
The
results
showed
population
ED<sub>50</sub>
0.88
±
0.45
h;
mean
ratio
effective
from
0
24
h
(AUEC<sub>0–24h</sub>)
preparations
0.95,
90%
confidence
interval
88.09–101.72%,
indicating
formulation
Desonide®.
plasma
concentration
(C<sub>max</sub>)
last
point
(AUC<sub>0–t</sub>)
T
R
20.8
11.5
pg/mL
versus
19.7
10.1
pg/mL,
respectively,
451.04
363.65
pgh/mL
541.47
581.41
pgh/mL,
respectively.
systemic
single
preparation.
All
volunteers
experienced
grade
1
AEs,
suggesting
administration
is
well
tolerated
healthy
population.
Conclusions:
demonstrated
applicability
skins
